LIVIVO - Search results -

Search results

Result 1 - 10 of total 254

Search options

Book: Phosphoinositide 3-kinase signalling pathway

Lam, Eric W.-F.

the key to cell proliferation and death

2006

Author's details	Eric W.-F. Lam
Language	English
Size	XIII, 238 S. : Ill., graph. Darst.
Publisher	Imperial College Press
Publishing place	London
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT014733240
ISBN	1-86094-626-7 ; 978-1-86094-626-4
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2006 A 4512	order for loan	Magazin

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Lysophosphatidic Acid Signalling Regulates Human Sperm Viability via the Phosphoinositide 3-Kinase/AKT Pathway.

Liao, Hao-Yu / O'Flaherty, Cristian

Cells

2023 Volume 12, Issue 17

Abstract: Lysophosphatidic acid (LPA) signalling is essential for maintaining germ cell viability during ...

Abstract	Lysophosphatidic acid (LPA) signalling is essential for maintaining germ cell viability during mouse spermatogenesis; however, its role in human spermatozoa is unknown. We previously demonstrated that peroxiredoxin 6 (PRDX6) calcium-independent phospholipase A
MeSH term(s)	Humans ; Male ; Lysophospholipids/pharmacology ; Peroxiredoxin VI ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt ; Semen
Chemical Substances	lysophosphatidic acid (PG6M3969SG) ; Lysophospholipids ; Peroxiredoxin VI (EC 1.11.1.15) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
Language	English
Publishing date	2023-09-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells12172196
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Trehalose hydrolysis and transport-related genes promote Bombyx mori nucleopolyhedrovirus proliferation through the phosphoinositide 3-kinase-Akt signalling pathway in BmN cell.

Wang, Jie / Zhu, Han-Dan / Wang, Yan-Xiang / Guo, Zhe-Xiao / Liu, Ying-Xue / Huang, Zhi-Hao / Zhu, Lin-Bao / Liu, Ming-Hui / Liu, Shi-Huo / Xu, Jia-Ping

Developmental and comparative immunology

2022 Volume 140, Page(s) 104625

Abstract: ... the expression of BmPI3K, BmPDK1 and BmAkt and inhibit the expression of BmFoxO in the phosphoinositide 3-kinase ... PI3K)-Akt signalling pathway. Similarly, the increased trehalose level in BmN cells could promote ... Akt signalling pathway to facilitate BmNPV proliferation. These findings help clarify the relationship ...

Abstract	The reprogramming of host physiology has been considered an essential process for baculovirus propagation. Trehalose, the main sugar in insect blood, plays a crucial role as an instant energy source. Although the trehalose level is modulated following infection with Bombyx mori nucleopolyhedrovirus (BmNPV), the mechanism of trehalose metabolism in response to BmNPV infection is still unclear. In this study, we demonstrated that the trehalose level tended to be lower in BmNPV-infected hemolymph and higher in the midgut. The omics analysis revealed that two trehalose transporters, BmTret1-1 and BmTret1-2, and trehalase, BmTRE1 and BmTRE2, were differentially expressed in the midgut after BmNPV infection. BmTret1-1 and BmTret1-2 had the ability to transport trehalose into the cell and promoted cellular absorption of trehalose. Furthermore, the functions of BmTret1-1, BmTret1-2, BmTRE1 and BmTRE2 in BmNPV infection were analyzed. These genes were upregulated in the midgut after BmNPV infection. Virus amplification analysis revealed that these genes could promote BmNPV proliferation in BmN cells. In addition, these genes could promote the expression of BmPI3K, BmPDK1 and BmAkt and inhibit the expression of BmFoxO in the phosphoinositide 3-kinase (PI3K)-Akt signalling pathway. Similarly, the increased trehalose level in BmN cells could promote the expression of BmPI3K, BmPDK1 and BmAkt and inhibit the expression of BmFoxO. Taken together, BmNPV infection promote the expression of trehalose hydrolysis and transport-related genes. These changes affect the PI3K-Akt signalling pathway to facilitate BmNPV proliferation. These findings help clarify the relationship between trehalose metabolism and BmNPV infection.
MeSH term(s)	Animals ; Phosphatidylinositol 3-Kinases/metabolism ; Hydrolysis ; Proto-Oncogene Proteins c-akt/metabolism ; Trehalose/metabolism ; Cell Proliferation ; Bombyx ; Insect Proteins/genetics ; Insect Proteins/metabolism
Chemical Substances	Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Trehalose (B8WCK70T7I) ; Insect Proteins
Language	English
Publishing date	2022-12-23
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2022.104625
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1327: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Inhibitors of phosphoinositide 3-kinase (PI3K) and phosphoinositide 3-kinase-related protein kinase family (PIKK).

Huang, Xueqin / You, Li / Nepovimova, Eugenie / Psotka, Miroslav / Malinak, David / Valko, Marian / Sivak, Ladislav / Korabecny, Jan / Heger, Zbynek / Adam, Vojtech / Wu, Qinghua / Kuca, Kamil

Journal of enzyme inhibition and medicinal chemistry

2023 Volume 38, Issue 1, Page(s) 2237209

Abstract: Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are ... repair. Dysfunction of PIKK members and aberrant stimulation of the PI3K/AKT/mTOR signalling pathway are ... two structurally related families of kinases that play vital roles in cell growth and DNA damage ...

Abstract	Phosphoinositide 3-kinases (PI3K) and phosphoinositide 3-kinase-related protein kinases (PIKK) are two structurally related families of kinases that play vital roles in cell growth and DNA damage repair. Dysfunction of PIKK members and aberrant stimulation of the PI3K/AKT/mTOR signalling pathway are linked to a plethora of diseases including cancer. In recent decades, numerous inhibitors related to the PI3K/AKT/mTOR signalling have made great strides in cancer treatment, like copanlisib and sirolimus. Notably, most of the PIKK inhibitors (such as VX-970 and M3814) related to DNA damage response have also shown good efficacy in clinical trials. However, these drugs still require a suitable combination therapy to overcome drug resistance or improve antitumor activity. Based on the aforementioned facts, we summarised the efficacy of PIKK, PI3K, and AKT inhibitors in the therapy of human malignancies and the resistance mechanisms of targeted therapy, in order to provide deeper insights into cancer treatment.
MeSH term(s)	Humans ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinase/therapeutic use ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphoinositide-3 Kinase Inhibitors/pharmacology ; TOR Serine-Threonine Kinases/metabolism ; Neoplasms/drug therapy ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
Chemical Substances	Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphoinositide-3 Kinase Inhibitors ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-07-24
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2082578-X
ISSN	1475-6374 ; 1475-6366
ISSN (online)	1475-6374
ISSN	1475-6366
DOI	10.1080/14756366.2023.2237209
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 3004: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Trehalose hydrolysis and transport–related genes promote Bombyx mori nucleopolyhedrovirus proliferation through the phosphoinositide 3-kinase–Akt signalling pathway in BmN cell

Wang, Jie / Zhu, Han-Dan / Wang, Yan-Xiang / Guo, Zhe-Xiao / Liu, Ying-Xue / Huang, Zhi-Hao / Zhu, Lin-Bao / Liu, Minghui / Liu, Shi-Huo / Xu, Jia-Ping

Developmental and Comparative Immunology. 2023 Mar., v. 140 p.104625-

2023

Abstract: ... the expression of BmPI3K, BmPDK1 and BmAkt and inhibit the expression of BmFoxO in the phosphoinositide 3-kinase ... PI3K)–Akt signalling pathway. Similarly, the increased trehalose level in BmN cells could promote ... Akt signalling pathway to facilitate BmNPV proliferation. These findings help clarify the relationship ...

Abstract	The reprogramming of host physiology has been considered an essential process for baculovirus propagation. Trehalose, the main sugar in insect blood, plays a crucial role as an instant energy source. Although the trehalose level is modulated following infection with Bombyx mori nucleopolyhedrovirus (BmNPV), the mechanism of trehalose metabolism in response to BmNPV infection is still unclear. In this study, we demonstrated that the trehalose level tended to be lower in BmNPV-infected hemolymph and higher in the midgut. The omics analysis revealed that two trehalose transporters, BmTret1-1 and BmTret1-2, and trehalase, BmTRE1 and BmTRE2, were differentially expressed in the midgut after BmNPV infection. BmTret1-1 and BmTret1-2 had the ability to transport trehalose into the cell and promoted cellular absorption of trehalose. Furthermore, the functions of BmTret1-1, BmTret1-2, BmTRE1 and BmTRE2 in BmNPV infection were analyzed. These genes were upregulated in the midgut after BmNPV infection. Virus amplification analysis revealed that these genes could promote BmNPV proliferation in BmN cells. In addition, these genes could promote the expression of BmPI3K, BmPDK1 and BmAkt and inhibit the expression of BmFoxO in the phosphoinositide 3-kinase (PI3K)–Akt signalling pathway. Similarly, the increased trehalose level in BmN cells could promote the expression of BmPI3K, BmPDK1 and BmAkt and inhibit the expression of BmFoxO. Taken together, BmNPV infection promote the expression of trehalose hydrolysis and transport–related genes. These changes affect the PI3K–Akt signalling pathway to facilitate BmNPV proliferation. These findings help clarify the relationship between trehalose metabolism and BmNPV infection.
Keywords	Bombyx mori nucleopolyhedrovirus ; absorption ; blood ; energy ; hemolymph ; hydrolysis ; immunology ; insects ; metabolism ; midgut ; phosphatidylinositol 3-kinase ; trehalase ; trehalose ; viruses ; Bombyx mori ; Trehalose hydrolysis and transport ; B. mori nucleopolyhedrovirus ; PI3K-Akt signalling pathway
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	752411-0
ISSN	1879-0089 ; 0145-305X
ISSN (online)	1879-0089
ISSN	0145-305X
DOI	10.1016/j.dci.2022.104625
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1327: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Phosphoinositide 3-kinase signalling in the nucleolus.

Morovicz, Andrea Papdiné / Mazloumi Gavgani, Fatemeh / Jacobsen, Rhîan G / Skuseth Slinning, Malene / Turcu, Diana C / Lewis, Aurélia E

Advances in biological regulation

2021 Volume 83, Page(s) 100843

Abstract: The phosphoinositide 3-kinase (PI3K) signalling pathway plays key roles in many cellular processes ... of downstream phosphatidylinositol (3,4,5)trisphosphate effector proteins. ... focuses on nucleolar PI3K signalling and how it regulates rRNA synthesis, as well as on the identification ...

Abstract	The phosphoinositide 3-kinase (PI3K) signalling pathway plays key roles in many cellular processes and is altered in many diseases. The function and mode of action of the pathway have mostly been elucidated in the cytoplasm. However, many of the components of the PI3K pathway are also present in the nucleus at specific sub-nuclear sites including nuclear speckles, nuclear lipid islets and the nucleolus. Nucleoli are membrane-less subnuclear structures where ribosome biogenesis occurs. Processes leading to ribosome biogenesis are tightly regulated to maintain protein translation capacity of cells. This review focuses on nucleolar PI3K signalling and how it regulates rRNA synthesis, as well as on the identification of downstream phosphatidylinositol (3,4,5)trisphosphate effector proteins.
MeSH term(s)	Cell Nucleolus/genetics ; Cell Nucleolus/metabolism ; Cell Nucleus/genetics ; Cell Nucleus/metabolism ; Humans ; Phosphatidylinositol 3-Kinase/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Signal Transduction
Chemical Substances	Phosphatidylinositol 3-Kinase (EC 2.7.1.137)
Language	English
Publishing date	2021-12-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2667413-0
ISSN	2212-4934 ; 2212-4926
ISSN (online)	2212-4934
ISSN	2212-4926
DOI	10.1016/j.jbior.2021.100843
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uc I Zs.364: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas.

Janus, Joanna M / O'Shaughnessy, Ryan F L / Harwood, Catherine A / Maffucci, Tania

Cancers

2017 Volume 9, Issue 7

Abstract: ... some of the evidence indicating that activation of phosphoinositide 3-kinases (PI3Ks)-dependent signalling pathways ... suggesting that inhibition of these pathways can be beneficial to counteract the disease. With the growing ... the specific contribution of distinct components of the PI3Ks/Akt/mTOR pathways in order to identify the most ...

Abstract	Cutaneous squamous cell carcinoma (cSCC) derives from keratinocytes in the epidermis and accounts for 15-20% of all cutaneous malignancies. Although it is usually curable by surgery, 5% of these tumours metastasise leading to poor prognosis mostly because of a lack of therapies and validated biomarkers. As the incidence rate is rising worldwide it has become increasingly important to better understand the mechanisms involved in cSCC development and progression in order to develop therapeutic strategies. Here we discuss some of the evidence indicating that activation of phosphoinositide 3-kinases (PI3Ks)-dependent signalling pathways (in particular the PI3Ks targets Akt and mTOR) has a key role in cSCC. We further discuss available data suggesting that inhibition of these pathways can be beneficial to counteract the disease. With the growing number of different inhibitors currently available, it would be important to further investigate the specific contribution of distinct components of the PI3Ks/Akt/mTOR pathways in order to identify the most promising molecular targets and the best strategy to inhibit cSCC.
Language	English
Publishing date	2017-07-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers9070086
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Class I Phosphoinositide 3-Kinase

Mazloumi Gavgani, Fatemeh / Smith Arnesen, Victoria / Jacobsen, Rhîan G / Krakstad, Camilla / Hoivik, Erling A / Lewis, Aurélia E

International journal of molecular sciences

2018 Volume 19, Issue 12

Abstract: The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading ... to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway ... tensin homologue, PTEN. Endometrial carcinomas harbour frequent alterations in components of the pathway ...

Abstract	The phosphoinositide 3-kinase (PI3K) signalling pathway is highly dysregulated in cancer, leading to elevated PI3K signalling and altered cellular processes that contribute to tumour development. The pathway is normally orchestrated by class I PI3K enzymes and negatively regulated by the phosphatase and tensin homologue, PTEN. Endometrial carcinomas harbour frequent alterations in components of the pathway, including changes in gene copy number and mutations, in particular in the oncogene
MeSH term(s)	Animals ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Endometrial Neoplasms/enzymology ; Endometrial Neoplasms/genetics ; Endometrial Neoplasms/metabolism ; Female ; Humans ; PTEN Phosphohydrolase/genetics ; PTEN Phosphohydrolase/metabolism ; Phosphatidylinositol 3-Kinase/genetics ; Phosphatidylinositol 3-Kinase/metabolism
Chemical Substances	Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; PTEN Phosphohydrolase (EC 3.1.3.67)
Language	English
Publishing date	2018-12-07
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms19123931
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Catestatin induces glycogenesis by stimulating the phosphoinositide 3-kinase-AKT pathway.

Bandyopadhyay, Gautam / Tang, Kechun / Webster, Nicholas J G / van den Bogaart, Geert / Mahata, Sushil K

Acta physiologica (Oxford, England)

2022 Volume 235, Issue 1, Page(s) e13775

Abstract: ... dependent kinase-1 (PDK-1), GYS2, glycogen synthase kinase-3β (GSK-3β), AKT (a kinase in AKR mouse ... that produces Thymoma)/PKB (protein kinase B) and mammalian/mechanistic target of rapamycin (mTOR ... synthesis from UDPG, (c) reducing glycogenolysis and (d) enhancing downstream insulin signalling. ...

Abstract	Aim: Defects in hepatic glycogen synthesis contribute to post-prandial hyperglycaemia in type 2 diabetic patients. Chromogranin A (CgA) peptide Catestatin (CST: hCgA Methods: We determined liver glycogen, glucose-6-phosphate (G6P), uridine diphosphate glucose (UDPG) and glycogen synthase (GYS2) activities; plasma insulin, glucagon, noradrenaline and adrenaline levels in wild-type (WT) as well as in CST knockout (CST-KO) mice; glycogen synthesis and glycogenolysis in primary hepatocytes. We also analysed phosphorylation signals of insulin receptor (IR), insulin receptor substrate-1 (IRS-1), phosphatidylinositol-dependent kinase-1 (PDK-1), GYS2, glycogen synthase kinase-3β (GSK-3β), AKT (a kinase in AKR mouse that produces Thymoma)/PKB (protein kinase B) and mammalian/mechanistic target of rapamycin (mTOR) by immunoblotting. Results: CST stimulated glycogen accumulation in fed and fasted liver and in primary hepatocytes. CST reduced plasma noradrenaline and adrenaline levels. CST also directly stimulated glycogenesis and inhibited noradrenaline and adrenaline-induced glycogenolysis in hepatocytes. In addition, CST elevated the levels of UDPG and increased GYS2 activity. CST-KO mice had decreased liver glycogen that was restored by treatment with CST, reinforcing the crucial role of CST in hepatic glycogenesis. CST improved insulin signals downstream of IR and IRS-1 by enhancing phospho-AKT signals through the stimulation of PDK-1 and mTORC2 (mTOR Complex 2, rapamycin-insensitive complex) activities. Conclusions: CST directly promotes the glycogenic pathway by (a) reducing glucose production, (b) increasing glycogen synthesis from UDPG, (c) reducing glycogenolysis and (d) enhancing downstream insulin signalling.
MeSH term(s)	Animals ; Chromogranin A/pharmacology ; Epinephrine/pharmacology ; Glucose/metabolism ; Glycogen ; Glycogen Synthase Kinase 3 beta ; Humans ; Insulin/metabolism ; Liver Glycogen ; Mammals ; Mice ; Norepinephrine ; Peptide Fragments ; Phosphatidylinositol 3-Kinase ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Sirolimus ; TOR Serine-Threonine Kinases ; Uridine Diphosphate Glucose
Chemical Substances	Chromogranin A ; Insulin ; Liver Glycogen ; Peptide Fragments ; chromogranin A (344-364) ; Glycogen (9005-79-2) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Glucose (IY9XDZ35W2) ; Uridine Diphosphate Glucose (V50K1D7P4Y) ; Sirolimus (W36ZG6FT64) ; Norepinephrine (X4W3ENH1CV) ; Epinephrine (YKH834O4BH)
Language	English
Publishing date	2022-02-04
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2218636-0
ISSN	1748-1716 ; 1748-1708
ISSN (online)	1748-1716
ISSN	1748-1708
DOI	10.1111/apha.13775
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Uc I Zs 229: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Novel roles for class II Phosphoinositide 3-Kinase C2β in signalling pathways involved in prostate cancer cell invasion.

Mavrommati, Ioanna / Cisse, Ouma / Falasca, Marco / Maffucci, Tania

Scientific reports

2016 Volume 6, Page(s) 23277

Abstract: Phosphoinositide 3-kinases (PI3Ks) regulate several cellular functions ... to other PI3Ks, there is still a limited understanding of the signalling pathways that can be specifically ... of the transcription factor Slug. These data identify novel signalling pathways specifically regulated by PI3K-C2β and ...

Abstract	Phosphoinositide 3-kinases (PI3Ks) regulate several cellular functions such as proliferation, growth, survival and migration. The eight PI3K isoforms are grouped into three classes and the three enzymes belonging to the class II subfamily (PI3K-C2α, β and γ) are the least investigated amongst all PI3Ks. Interest on these isoforms has been recently fuelled by the identification of specific physiological roles for class II PI3Ks and by accumulating evidence indicating their involvement in human diseases. While it is now established that these isoforms can regulate distinct cellular functions compared to other PI3Ks, there is still a limited understanding of the signalling pathways that can be specifically regulated by class II PI3Ks. Here we show that PI3K-C2β regulates mitogen-activated protein kinase kinase (MEK1/2) and extracellular signal-regulated kinase (ERK1/2) activation in prostate cancer (PCa) cells. We further demonstrate that MEK/ERK and PI3K-C2β are required for PCa cell invasion but not proliferation. In addition we show that PI3K-C2β but not MEK/ERK regulates PCa cell migration as well as expression of the transcription factor Slug. These data identify novel signalling pathways specifically regulated by PI3K-C2β and they further identify this enzyme as a key regulator of PCa cell migration and invasion.
MeSH term(s)	Butadienes/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects ; Down-Regulation ; Epidermal Growth Factor/pharmacology ; Humans ; MAP Kinase Kinase 1/metabolism ; MAP Kinase Kinase 2/metabolism ; Male ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Nitriles/pharmacology ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphoinositide-3 Kinase Inhibitors ; Phosphorylation/drug effects ; Prostatic Neoplasms/metabolism ; Prostatic Neoplasms/pathology ; Protein Isoforms/antagonists & inhibitors ; Protein Isoforms/genetics ; Protein Isoforms/metabolism ; RNA Interference ; RNA, Small Interfering/metabolism ; Signal Transduction/drug effects ; Snail Family Transcription Factors/metabolism
Chemical Substances	Butadienes ; Nitriles ; Phosphoinositide-3 Kinase Inhibitors ; Protein Isoforms ; RNA, Small Interfering ; SNAI1 protein, human ; Snail Family Transcription Factors ; U 0126 ; Epidermal Growth Factor (62229-50-9) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24) ; MAP Kinase Kinase 1 (EC 2.7.12.2) ; MAP Kinase Kinase 2 (EC 2.7.12.2)
Language	English
Publishing date	2016-03-17
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep23277
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

To top

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito