Article ; Online: Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients' B Cells.
2020 Volume 182, Issue 1, Page(s) 73–84.e16
Abstract: ... the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput single-cell RNA and VDJ ... sequencing of antigen-enriched B cells from 60 convalescent patients. From 8,558 antigen-binding IgG1 ...
| Abstract | The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here, we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput single-cell RNA and VDJ sequencing of antigen-enriched B cells from 60 convalescent patients. From 8,558 antigen-binding IgG1 |
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| MeSH term(s) | Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/metabolism ; Antibodies, Neutralizing/administration & dosage ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/isolation & purification ; Antibodies, Neutralizing/metabolism ; B-Lymphocytes/immunology ; COVID-19 ; Convalescence ; Coronavirus Infections/immunology ; High-Throughput Nucleotide Sequencing ; Humans ; Mice ; Pandemics ; Pneumonia, Viral/immunology ; Sequence Analysis, RNA ; Single-Cell Analysis ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/metabolism ; VDJ Exons |
| Chemical Substances | Antibodies, Monoclonal ; Antibodies, Neutralizing ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-05-18 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 187009-9 |
| ISSN | 1097-4172 ; 0092-8674 |
| ISSN (online) | 1097-4172 |
| ISSN | 0092-8674 |
| DOI | 10.1016/j.cell.2020.05.025 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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