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Article ; Online: Clinical characteristics of Coronavirus Disease 2019 patients in Beijing, China.

Cao, Zhenhuan / Li, Tongzeng / Liang, Lianchun / Wang, Haibo / Wei, Feili / Meng, Sha / Cai, Miaotian / Zhang, Yulong / Xu, Hui / Zhang, Jiaying / Jin, Ronghua

PloS one

2020 Volume 15, Issue 6, Page(s) e0234764

Abstract: ... about the disease outside of Wuhan in China. In this retrospective cohort study, we report the early clinical ... features of 80 patients with COVID-19 admitted to the hospital in Beijing. The results show that 27 (33.8 ... The outbreak of Coronavirus Disease (COVID-19) in Wuhan have affected more than 250 countries and ...

Abstract	The outbreak of Coronavirus Disease (COVID-19) in Wuhan have affected more than 250 countries and regions worldwide. However, most of the clinical studies have been focused on Wuhan, and little is known about the disease outside of Wuhan in China. In this retrospective cohort study, we report the early clinical features of 80 patients with COVID-19 admitted to the hospital in Beijing. The results show that 27 (33.8%) patients had severe illness. Six (7.5%) patients were admitted to the ICU, and 3 (3.8%) patients died. Forty-eight percent (39/80) of the patients had a history of living/traveling in Wuhan. Patients with severe- illness were significantly older (average age, 71 years old vs 44 years old) and had a high incidence of expectoration (59.3% vs 34.0%), shortness of breath (92.6% vs 9.4%), anorexia (51.9% vs 18.9%) and confusion(18.5% vs 0%) compared with nonsevere patients. The systolic blood pressure (median, 130 mmHg vs 120 mmHg) was higher and the oxygen saturation (median, 98.3% vs 92.0%) was significantly lower in severe patients than nonsevere patients. In addition, myoglobin (median, 56.0 ng/mL vs 35.0 ng/mL), troponin I (median, 0.02 pg/mL vs 0.01 pg/mL), C-reactive protein (median, 69.7 mg/L vs 12.9 mg/L) and neutrophils (median, 3.3×109/L vs 2.2×109/L) were significantly increased, while lymphocytes (median, 0.8×109/L vs 1.2×109/L), albumin (mean, 32.8 g/L vs 36.8 g/L) and the creatinine clearance rate (median, 91.2 vs 108.2 ml/min/1.73m2) were significantly decreased among severe patients. Our study revealed that older patients with high levels of C-reactive protein, myoglobin, troponin I, and neutrophil and high systolic blood pressure as well as low levels of lymphocytes, and albumin and a low creatinine clearance rate and oxygen saturation were more likely to have severe disease.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Beijing/epidemiology ; Betacoronavirus/genetics ; C-Reactive Protein/analysis ; COVID-19 ; Coronavirus Infections/blood ; Coronavirus Infections/epidemiology ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Creatinine/blood ; Female ; Hospitalization ; Humans ; Hypertension ; Lymphocytes ; Male ; Middle Aged ; Myoglobin/blood ; Neutrophils ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Serum Albumin, Human/analysis ; Severity of Illness Index ; Troponin I/blood
Chemical Substances	Myoglobin ; Troponin I ; C-Reactive Protein (9007-41-4) ; Creatinine (AYI8EX34EU) ; Serum Albumin, Human (ZIF514RVZR)
Keywords	covid19
Language	English
Publishing date	2020-06-17
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0234764
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical characteristics of Coronavirus Disease 2019 patients in Beijing, China.

Zhenhuan Cao / Tongzeng Li / Lianchun Liang / Haibo Wang / Feili Wei / Sha Meng / Miaotian Cai / Yulong Zhang / Hui Xu / Jiaying Zhang / Ronghua Jin

PLoS ONE, Vol 15, Iss 6, p e

2020 Volume 0234764

Abstract	The outbreak of Coronavirus Disease (COVID-19) in Wuhan have affected more than 250 countries and regions worldwide. However, most of the clinical studies have been focused on Wuhan, and little is known about the disease outside of Wuhan in China. In this retrospective cohort study, we report the early clinical features of 80 patients with COVID-19 admitted to the hospital in Beijing. The results show that 27 (33.8%) patients had severe illness. Six (7.5%) patients were admitted to the ICU, and 3 (3.8%) patients died. Forty-eight percent (39/80) of the patients had a history of living/traveling in Wuhan. Patients with severe- illness were significantly older (average age, 71 years old vs 44 years old) and had a high incidence of expectoration (59.3% vs 34.0%), shortness of breath (92.6% vs 9.4%), anorexia (51.9% vs 18.9%) and confusion(18.5% vs 0%) compared with nonsevere patients. The systolic blood pressure (median, 130 mmHg vs 120 mmHg) was higher and the oxygen saturation (median, 98.3% vs 92.0%) was significantly lower in severe patients than nonsevere patients. In addition, myoglobin (median, 56.0 ng/mL vs 35.0 ng/mL), troponin I (median, 0.02 pg/mL vs 0.01 pg/mL), C-reactive protein (median, 69.7 mg/L vs 12.9 mg/L) and neutrophils (median, 3.3×109/L vs 2.2×109/L) were significantly increased, while lymphocytes (median, 0.8×109/L vs 1.2×109/L), albumin (mean, 32.8 g/L vs 36.8 g/L) and the creatinine clearance rate (median, 91.2 vs 108.2 ml/min/1.73m2) were significantly decreased among severe patients. Our study revealed that older patients with high levels of C-reactive protein, myoglobin, troponin I, and neutrophil and high systolic blood pressure as well as low levels of lymphocytes, and albumin and a low creatinine clearance rate and oxygen saturation were more likely to have severe disease.
Keywords	Medicine ; R ; Science ; Q ; covid19
Subject code	610
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Clinical characteristics of Coronavirus Disease 2019 patients in Beijing, China

Cao, Zhenhuan / Li, Tongzeng / Liang, Lianchun / Wang, Haibo / Wei, Feili / Meng, Sha / Cai, Miaotian / Zhang, Yulong / Xu, Hui / Zhang, Jiaying / Jin, Ronghua

PLoS One

Abstract	The outbreak of Coronavirus Disease (COVID-19) in Wuhan have affected more than 250 countries and regions worldwide. However, most of the clinical studies have been focused on Wuhan, and little is known about the disease outside of Wuhan in China. In this retrospective cohort study, we report the early clinical features of 80 patients with COVID-19 admitted to the hospital in Beijing. The results show that 27 (33.8%) patients had severe illness. Six (7.5%) patients were admitted to the ICU, and 3 (3.8%) patients died. Forty-eight percent (39/80) of the patients had a history of living/traveling in Wuhan. Patients with severe- illness were significantly older (average age, 71 years old vs 44 years old) and had a high incidence of expectoration (59.3% vs 34.0%), shortness of breath (92.6% vs 9.4%), anorexia (51.9% vs 18.9%) and confusion(18.5% vs 0%) compared with nonsevere patients. The systolic blood pressure (median, 130 mmHg vs 120 mmHg) was higher and the oxygen saturation (median, 98.3% vs 92.0%) was significantly lower in severe patients than nonsevere patients. In addition, myoglobin (median, 56.0 ng/mL vs 35.0 ng/mL), troponin I (median, 0.02 pg/mL vs 0.01 pg/mL), C-reactive protein (median, 69.7 mg/L vs 12.9 mg/L) and neutrophils (median, 3.3×109/L vs 2.2×109/L) were significantly increased, while lymphocytes (median, 0.8×109/L vs 1.2×109/L), albumin (mean, 32.8 g/L vs 36.8 g/L) and the creatinine clearance rate (median, 91.2 vs 108.2 ml/min/1.73m2) were significantly decreased among severe patients. Our study revealed that older patients with high levels of C-reactive protein, myoglobin, troponin I, and neutrophil and high systolic blood pressure as well as low levels of lymphocytes, and albumin and a low creatinine clearance rate and oxygen saturation were more likely to have severe disease.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #601962
Database	COVID19

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Article ; Online: Epidemiological and clinical characteristics of imported cases of COVID-19: a multicenter study.

Zhang, Jinjun / Yang, Shixiong / Xu, Yi / Qin, Xinyan / Liu, Jialiang / Guo, Jinjun / Tian, Sijia / Wang, Shaoping / Liao, Kai / Zhang, Ying / Ma, Yu / Chen, Yuguo

BMC infectious diseases

2021 Volume 21, Issue 1, Page(s) 406

Abstract: Background: The coronavirus disease 2019 (COVID-19) pandemic continues to expand. Herein ... from a multicenter study conducted in four cities in China excluding Wuhan.: Methods: A total of 478 patients ... transferred by emergency medical services to designated hospitals in four major cities in China (Beijing ...

Abstract	Background: The coronavirus disease 2019 (COVID-19) pandemic continues to expand. Herein, we report the epidemiological and clinical features of 478 patients with confirmed COVID-19 from a multicenter study conducted in four cities in China excluding Wuhan. Methods: A total of 478 patients transferred by emergency medical services to designated hospitals in four major cities in China (Beijing, Chongqing, Jinan, and Nanning) were enrolled. We compared the characteristics of imported and indigenous cases and calculated the frequencies of fatal, severe, mild, and asymptomatic disease. The results were used to generate a pyramid of COVID-19 severity. Results: The mean age of patients with COVID-19 was 46.9 years and 49.8% were male. The most common symptoms at onset were fever (69.7%), cough (47.5%), fatigue (24.5%), dyspnea (8.4%), and headache (7.9%). Most cases (313, 65.5%) were indigenous, while 165 (34.5%) were imported. Imported cases dominated during the early stages of the pandemic, but decreased from 1 February 2020 as indigenous cases rose sharply. Compared with indigenous cases, imported cases differed significantly in terms of sex (P = 0.002), severity of disease (P = 0.006), occurrence of fever (P < 0.001), family clustering (P < 0.001), history of contact (P < 0.001), and primary outcome (P < 0.001). Conclusions: Within the population studied, imported cases had distinct characteristics from those of indigenous cases, with lower fatality rates and higher discharge rates. New infections shifted from imported cases to local infection gradually, and overall infections have declined to a low level. We suggest that preventing import of cases and controlling spread within local areas can help prevent SARS-CoV-2 infection spread.
MeSH term(s)	Adolescent ; Adult ; Aged ; Beijing/epidemiology ; COVID-19/epidemiology ; COVID-19/etiology ; COVID-19/therapy ; China/epidemiology ; Cough/epidemiology ; Cough/virology ; Fatigue/epidemiology ; Fatigue/virology ; Female ; Fever/epidemiology ; Fever/virology ; Humans ; Male ; Middle Aged ; Patient Discharge ; Time Factors ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2021-05-03
Publishing country	England
Document type	Journal Article ; Multicenter Study
ISSN	1471-2334
ISSN (online)	1471-2334
DOI	10.1186/s12879-021-06096-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Genomic, immunological, and clinical analysis of COVID-19 vaccine breakthrough infections in Beijing, China.

Tian, Di / Song, Yang / Zhang, Man / Pan, Yang / Ge, Ziruo / Zhang, Yao / Ren, Xingxiang / Wen, Jing / Xu, Yanli / Guo, Hong / Yang, Peng / Chen, Zhihai / Xu, Wenbo

Journal of medical virology

2022 Volume 94, Issue 5, Page(s) 2237–2249

Abstract: As the coronavirus disease 2019 (COVID-19) pandemic is still ongoing and ... but two patients developed severe disease in the unvaccinated group. The median time of viral shedding ... reverse-transcription polymerase chain reaction results or viral shedding time. In conclusion, among vaccinated patients ...

Abstract	As the coronavirus disease 2019 (COVID-19) pandemic is still ongoing and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants are circulating worldwide, an increasing number of breakthrough infections are being detected despite the good efficacy of COVID-19 vaccines. Data on 88 COVID-19 breakthrough cases (breakthrough infections group) and 41 unvaccinated cases (unvaccinated group) from June 1 to August 22, 2021, were extracted from a cloud database established at Beijing Ditan Hospital to evaluate the clinical, immunological, and genomic characteristics of COVID-19 breakthrough infections. Among these 129 COVID-19 cases, 33 whole genomes were successfully sequenced, of which 23 were Delta variants, including 15 from the breakthrough infections group. Asymptomatic and mild cases predominated in both groups, but two patients developed severe disease in the unvaccinated group. The median time of viral shedding in the breakthrough infections group was significantly lower than that in the unvaccinated group (p = 0.003). In the breakthrough infections group, the IgG titers showed a significantly increasing trend (p = 0.007), and the CD4 + T lymphocyte count was significantly elevated (p = 0.018). For people infected with the Delta variant in the two groups, no significant difference was observed in either the quantitative reverse-transcription polymerase chain reaction results or viral shedding time. In conclusion, among vaccinated patients, the cases of COVID-19 vaccine breakthrough infections were mainly asymptomatic and mild, IgG titers were significantly increased and rose rapidly, and the viral shedding time was shorter.
MeSH term(s)	Beijing/epidemiology ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Genomics ; Humans ; SARS-CoV-2/genetics
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27636
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Article ; Online: Clinical features of patients with coronavirus disease 2019 from a designated hospital in Beijing, China.

Sun, Lijun / Shen, Lijun / Fan, Junfen / Gu, Fengjun / Hu, Mei / An, Yiran / Zhou, Qing / Fan, Huahao / Bi, Jingfeng

Journal of medical virology

2020 Volume 92, Issue 10, Page(s) 2055–2066

Abstract: Clinical and laboratory data on patients with coronavirus disease 2019 (COVID-19) in Beijing, China ... China, the symptoms of patients in Beijing are relatively mild. Older age, more comorbidities, and more ... remain extremely limited. In this study, we summarized the clinical characteristics of patients ...

Abstract	Clinical and laboratory data on patients with coronavirus disease 2019 (COVID-19) in Beijing, China, remain extremely limited. In this study, we summarized the clinical characteristics of patients with COVID-19 from a designated hospital in Beijing. In total, 55 patients with laboratory-confirmed SARS-CoV-2 infection in Beijing 302 Hospital were enrolled in this study. Demographic data, symptoms, comorbidities, laboratory values, treatments, and clinical outcomes were all collected and retrospectively analyzed. A total of 15 (27.3%) patients had severe symptoms, the mean age was 44.0 years (interquartile range [IQR], 34.0-56.0), and the median incubation period was 7.5 days (IQR, 5.0-11.8). A total of 26 (47.3%) patients had exposure history in Wuhan of less than 2 weeks, whereas 20 (36.4%) patients were associated with familial clusters. Also, eighteen (32.7%) patients had underlying comorbidities including hypertension. The most common symptom of illness was fever (45; 81.8%); 51 (92.7%) patients had abnormal findings on chest computed tomography. Laboratory findings showed that neutrophil count, percentage of lymphocyte, percentage of eosinophil, eosinophil count, erythrocyte sedimentation rate, albumin, and serum ferritin are potential risk factors for patients with a poor prognosis. A total of 26 patients (47.3%) were still hospitalized, whereas 29 (52.7%) patients had been discharged. Compared with patients in Wuhan, China, the symptoms of patients in Beijing are relatively mild. Older age, more comorbidities, and more abnormal prominent laboratory markers were associated with a severe condition. On the basis of antiviral drugs, it is observed that antibiotics treatment, appropriate dosage of corticosteroid, and gamma globulin therapy significantly improve patients' outcomes. Early identification and timely medical treatment are important to reduce the severity of patients with COVID-19.
MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Adult ; Age Factors ; Antiviral Agents/therapeutic use ; COVID-19/diagnostic imaging ; COVID-19/physiopathology ; COVID-19/therapy ; COVID-19/virology ; China ; Comorbidity ; Coronary Disease/diagnostic imaging ; Coronary Disease/physiopathology ; Coronary Disease/therapy ; Coronary Disease/virology ; Diabetes Mellitus/diagnostic imaging ; Diabetes Mellitus/physiopathology ; Diabetes Mellitus/therapy ; Diabetes Mellitus/virology ; Eosinophils/pathology ; Eosinophils/virology ; Female ; Ferritins/blood ; Fever/physiopathology ; Hospitalization ; Hospitals ; Humans ; Hypertension/diagnostic imaging ; Hypertension/physiopathology ; Hypertension/therapy ; Hypertension/virology ; Immunoglobulins, Intravenous/therapeutic use ; Infectious Disease Incubation Period ; Kidney Failure, Chronic/diagnostic imaging ; Kidney Failure, Chronic/physiopathology ; Kidney Failure, Chronic/therapy ; Kidney Failure, Chronic/virology ; Leukocyte Count ; Lymphocytes/pathology ; Lymphocytes/virology ; Male ; Middle Aged ; Neutrophils/pathology ; Neutrophils/virology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2/drug effects ; SARS-CoV-2/pathogenicity ; Severity of Illness Index ; Tomography, X-Ray Computed
Chemical Substances	Adrenal Cortex Hormones ; Antiviral Agents ; Immunoglobulins, Intravenous ; Ferritins (9007-73-2)
Keywords	covid19
Language	English
Publishing date	2020-06-12
Publishing country	United States
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.25966
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Article ; Online: Clinical characteristics of older patients infected with COVID-19: A descriptive study.

Niu, Shengmei / Tian, Sijia / Lou, Jing / Kang, Xuqin / Zhang, Luxi / Lian, Huixin / Zhang, Jinjun

Archives of gerontology and geriatrics

2020 Volume 89, Page(s) 104058

Abstract: ... patients with COVID-19 infection and analyzed the epidemiological and clinical characteristics ... Objectives: Since the outbreak of 2019 novel coronavirus (COVID-19), which has spread in the world ... of them.: Methods: We collected information on confirmed older patient transferred by Beijing ...

Abstract	Objectives: Since the outbreak of 2019 novel coronavirus (COVID-19), which has spread in the world rapidly. Population have a susceptibility to COVID-19, older people were more susceptible to have a variety diseases than younger, including COVID-19 infection with no doubt. This study focused on older patients with COVID-19 infection and analyzed the epidemiological and clinical characteristics of them. Methods: We collected information on confirmed older patient transferred by Beijing Emergency Medical Service (EMS) to the designated hospitals from Jan 20 to Feb 29, 2020. The information including demographic, epidemiological, clinical, classification of severity and outcomes. All cases were categorized into three groups and compared the difference between aged 50-64 years, 65-79 years and older than 80 years. Results: 56.7 % of elderly confirmed patients were male, fever (78.3 %), cough (56.7 %), dyspnea (30.0 %), and fatigue (23.3 %) were common symptoms of COVID-19 infection. Classification of severity has statistically significant differences between the three groups, compared with middle-aged patients and aged 65-79 years group, older than 80 years group had significant statistical differences in contacted to symptomatic case in 14 days. As of Feb 29, 38.3 % patients had discharged and 53.3 % patients remained in hospital in our study, the fatality of COVID-19 infection in elderly was 8.3 %. Conclusions: The COVID-19 infection is generally susceptible with a relatively high fatality rate in older patients, we should pay more attention to the elderly patients with COVID-19 infection.
MeSH term(s)	Aged ; Aged, 80 and over ; Betacoronavirus/isolation & purification ; COVID-19 ; China/epidemiology ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Cough/epidemiology ; Cough/virology ; Disease Outbreaks/prevention & control ; Fatigue/epidemiology ; Female ; Fever/epidemiology ; Fever/virology ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Discharge ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-04-10
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	603162-6
ISSN	1872-6976 ; 0167-4943
ISSN (online)	1872-6976
ISSN	0167-4943
DOI	10.1016/j.archger.2020.104058
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Article ; Online: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.

Huang, Chaolin / Wang, Yeming / Li, Xingwang / Ren, Lili / Zhao, Jianping / Hu, Yi / Zhang, Li / Fan, Guohui / Xu, Jiuyang / Gu, Xiaoying / Cheng, Zhenshun / Yu, Ting / Xia, Jiaan / Wei, Yuan / Wu, Wenjuan / Xie, Xuelei / Yin, Wen / Li, Hui / Liu, Min /

Xiao, Yan / Gao, Hong / Guo, Li / Xie, Jungang / Wang, Guangfa / Jiang, Rongmeng / Gao, Zhancheng / Jin, Qi / Wang, Jianwei / Cao, Bin

Lancet (London, England)

2020 Volume 395, Issue 10223, Page(s) 497–506

Abstract: ... betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and ... radiological characteristics and treatment and clinical outcomes of these patients.: Methods: All patients ... National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission. ...

Abstract	Background: A recent cluster of pneumonia cases in Wuhan, China, was caused by a novel betacoronavirus, the 2019 novel coronavirus (2019-nCoV). We report the epidemiological, clinical, laboratory, and radiological characteristics and treatment and clinical outcomes of these patients. Methods: All patients with suspected 2019-nCoV were admitted to a designated hospital in Wuhan. We prospectively collected and analysed data on patients with laboratory-confirmed 2019-nCoV infection by real-time RT-PCR and next-generation sequencing. Data were obtained with standardised data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection Consortium from electronic medical records. Researchers also directly communicated with patients or their families to ascertain epidemiological and symptom data. Outcomes were also compared between patients who had been admitted to the intensive care unit (ICU) and those who had not. Findings: By Jan 2, 2020, 41 admitted hospital patients had been identified as having laboratory-confirmed 2019-nCoV infection. Most of the infected patients were men (30 [73%] of 41); less than half had underlying diseases (13 [32%]), including diabetes (eight [20%]), hypertension (six [15%]), and cardiovascular disease (six [15%]). Median age was 49·0 years (IQR 41·0-58·0). 27 (66%) of 41 patients had been exposed to Huanan seafood market. One family cluster was found. Common symptoms at onset of illness were fever (40 [98%] of 41 patients), cough (31 [76%]), and myalgia or fatigue (18 [44%]); less common symptoms were sputum production (11 [28%] of 39), headache (three [8%] of 38), haemoptysis (two [5%] of 39), and diarrhoea (one [3%] of 38). Dyspnoea developed in 22 (55%) of 40 patients (median time from illness onset to dyspnoea 8·0 days [IQR 5·0-13·0]). 26 (63%) of 41 patients had lymphopenia. All 41 patients had pneumonia with abnormal findings on chest CT. Complications included acute respiratory distress syndrome (12 [29%]), RNAaemia (six [15%]), acute cardiac injury (five [12%]) and secondary infection (four [10%]). 13 (32%) patients were admitted to an ICU and six (15%) died. Compared with non-ICU patients, ICU patients had higher plasma levels of IL2, IL7, IL10, GSCF, IP10, MCP1, MIP1A, and TNFα. Interpretation: The 2019-nCoV infection caused clusters of severe respiratory illness similar to severe acute respiratory syndrome coronavirus and was associated with ICU admission and high mortality. Major gaps in our knowledge of the origin, epidemiology, duration of human transmission, and clinical spectrum of disease need fulfilment by future studies. Funding: Ministry of Science and Technology, Chinese Academy of Medical Sciences, National Natural Science Foundation of China, and Beijing Municipal Science and Technology Commission.
MeSH term(s)	Adult ; Age Distribution ; Aged ; COVID-19 ; China/epidemiology ; Comorbidity ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/transmission ; Cough/epidemiology ; Cough/virology ; Female ; Fever/epidemiology ; Fever/virology ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Myalgia/epidemiology ; Myalgia/virology ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/transmission ; Prognosis ; Radiography, Thoracic ; Respiratory Distress Syndrome/epidemiology ; Respiratory Distress Syndrome/virology ; Time Factors ; Tomography, X-Ray Computed ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-01-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(20)30183-5
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Article ; Online: Epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing, China.

He, Ming / Wang, Caiying / Xu, Lin / Zhang, Huimin / Liu, Yuhuan / Zhao, Yang / He, Shuxin / Zhang, Yanlan / Yang, Hongling / Liu, Yang / Miao, Min / Chen, Zhihai / Pang, Lin

Pediatric investigation

2020 Volume 4, Issue 4, Page(s) 230–235

Abstract: Importance: Within the coronavirus disease 2019 (COVID-19) global pandemic, more attention is ... To retrospectively determine the epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing ... to Beijing Ditan Hospital from January 2020 to June 2020, and analyzed their epidemiological characteristics ...

Abstract	Importance: Within the coronavirus disease 2019 (COVID-19) global pandemic, more attention is warranted for whether this new infectious disease has unique manifestations in children. Objective: To retrospectively determine the epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing, China. Methods: We collected data for 35 children diagnosed with COVID-19 who were admitted to Beijing Ditan Hospital from January 2020 to June 2020, and analyzed their epidemiological characteristics, clinical manifestations, laboratory examinations, chest imaging findings, treatments, and outcomes. Results: The children comprised 18 boys (51.4%) and 17 girls (48.6%) aged 6 months to 15 years. All patients had clear epidemiological history, with family clusters accounting for 28 cases (80.0%) and clear tracing of exposure to high epidemic areas in the remaining 7 cases (20.0%). Four (11.4%) patients were classified as asymptomatic, 17 (48.6%) as acute upper respiratory infection, and 14 (40.0%) as mild pneumonia, with no severe or critical cases. Clinical manifestations were mild, including fever in 18 (51.4%), cough in 14 (40.0%), and nausea and diarrhea in 7 (20.0%) patients. White blood cell count was mostly normal (26 cases, 74.3%) or decreased (7 cases, 20.0%); lymphocyte percentage was increased in 24 (68.7%); neutrophil percentage was decreased in 25 (71.4%); alanine aminotransferase was increased in 3 (8.6%); and serum potassium was decreased in 4 (11.4%). Time to negative viral nucleic acid testing was 2-42 days (mean: 14.0 ± 9.4 days). Chest imaging examination revealed that 20 patients (57.1%) had different forms of lung inflammation. Treatment was mainly isolation and nutritional support. Eleven patients were treated with interferon atomization inhalation. No patients required oxygen therapy. All 35 children were cured and discharged. Length of hospital stay was 9-54 days (mean: 25.4 ± 13.8 days). During regular follow-up after discharge, 5 children showed positivity again in the viral nucleic acid test and were re-hospitalized for observation and treatment. The mean length of re-hospitalization stay was 10.8 days. Interpretation: Children with COVID-19 mainly become infected within their family, and children of all ages are generally susceptible. The disease in children is mostly mild and the prognosis is good. Nucleic acid tests in some patients become positive again after discharge, suggesting that it is of great significance to carry out centralized isolation medical observations and active nucleic acid tests in close contacts for early detection of patients and routine epidemic prevention and control.
Language	English
Publishing date	2020-12-28
Publishing country	United States
Document type	Journal Article
ISSN	2574-2272
ISSN (online)	2574-2272
DOI	10.1002/ped4.12230
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Article ; Online: Characteristics and outcomes of COVID-19 in patients with plasma cell dyscrasias during the first Omicron wave in Beijing since December 2022: a retrospective study at a National Clinical Research Center for Hematologic Disease.

He, Qing / Dou, Xuelin / Liu, Yang / Wen, Lei / Wang, Fengrong / Peng, Nan / Gong, Lizhong / Li, Yue / Lu, Yao / Wang, Liru / Zhang, Xiaohui / Huang, Xiaojun / Lu, Jin

Annals of hematology

2023 Volume 102, Issue 10, Page(s) 2857–2864

Abstract: ... in Beijing, China in December 2022. We delineated characteristics and factors associated with adverse outcome ... The wave of coronavirus disease 2019 (COVID-19) with Omicron variant reached its first peak ... with the development of severe or critical disease. Among patients with severe or critical group, low levels of albumin ...

Abstract	The wave of coronavirus disease 2019 (COVID-19) with Omicron variant reached its first peak in Beijing, China in December 2022. We delineated characteristics and factors associated with adverse outcome of patients with plasma cell dyscrasias (PCDs) and COVID-19 during the first month of the wave. A total of 104 patients with a median age of 65 years were included in the study, with multiple myeloma (74%, n=77) and primary Immunoglobulin light chain amyloidosis (16.3%, n=17) being the two most common disease. Overall, severe or critical COVID-19 was developed in 18 (17.3%) patients, with a total all-cause mortality rate of 4.8% (n=5). The vaccination coverage was 41% and 48.1%, before and during the upsurge of Omicron, respectively, calling for the improvement of vaccination in PCD patients. Multivariable analysis revealed that age was the only independent risk factors (OR=1.14, 95% CI: 1.06-1.26, p = 0.002) associated with the development of severe or critical disease. Among patients with severe or critical group, low levels of albumin (HR=18.29; 95% CI: 1.82-183.44, p = 0.013) and high levels of lactic dehydrogenase (LDH) (HR=0.08; 95% CI: 0.01-0.65, p = 0.018) were associated with longer time to negative conversion of COVID-19.
MeSH term(s)	Humans ; Aged ; Beijing ; Retrospective Studies ; COVID-19/epidemiology ; SARS-CoV-2 ; Paraproteinemias ; Hematologic Diseases
Language	English
Publishing date	2023-07-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1064950-5
ISSN	1432-0584 ; 0939-5555 ; 0945-8077
ISSN (online)	1432-0584
ISSN	0939-5555 ; 0945-8077
DOI	10.1007/s00277-023-05350-y
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