Article: Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation.
2003 Volume 24, Issue 3, Page(s) 261–271
Abstract: ... of the components and actions of the RAS, including local tissue RASs, a renin receptor, ANG-converting enzyme-2 ... of the RAS in the regulation of cardiovascular and renal function is reviewed and discussed in light ... of these newly recognized components. ...
| Abstract | The renin-angiotensin system (RAS) is a coordinated hormonal cascade in the control of cardiovascular, renal, and adrenal function that governs body fluid and electrolyte balance, as well as arterial pressure. The classical RAS consists of a circulating endocrine system in which the principal effector hormone is angiotensin (ANG) II. ANG is produced by the action of renin on angiotensinogen to form ANG I and its subsequent conversion to the biologically active octapeptide by ANG-converting enzyme. ANG II actions are mediated via the ANG type 1 receptor. Here, we discuss recent advances in our understanding of the components and actions of the RAS, including local tissue RASs, a renin receptor, ANG-converting enzyme-2, ANG (1-7), the function of the ANG type 2 receptor, and ANG receptor heterodimerization. The role of the RAS in the regulation of cardiovascular and renal function is reviewed and discussed in light of these newly recognized components. |
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| MeSH term(s) | Angiotensin I/physiology ; Animals ; Cardiovascular Physiological Phenomena ; Dimerization ; Humans ; Isoenzymes/physiology ; Kidney/physiology ; Peptide Fragments/physiology ; Peptidyl-Dipeptidase A/physiology ; Receptor, Angiotensin, Type 2/physiology ; Receptors, Angiotensin/chemistry ; Receptors, Cell Surface/physiology ; Renin/metabolism ; Renin-Angiotensin System/physiology | |||||
| Chemical Substances | Isoenzymes ; Peptide Fragments ; Receptor, Angiotensin, Type 2 ; Receptors, Angiotensin ; Receptors, Cell Surface ; Angiotensin I (9041-90-1) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Renin (EC 3.4.23.15) ; angiotensin I (1-7) (IJ3FUK8MOF) | |||||
| Language | English | |||||
| Publishing date | 2003-06 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 603096-8 | |||||
| ISSN | 1945-7189 ; 0163-769X | |||||
| ISSN (online) | 1945-7189 | |||||
| ISSN | 0163-769X | |||||
| DOI | 10.1210/er.2003-0001 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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