Article: Chemical mediators and the resolution of airway inflammation.
Allergology international : official journal of the Japanese Society of Allergology
2008 Volume 57, Issue 4, Page(s) 299–305
Abstract: ... Some of these counter-regulatory lipid mediators have been identified in the airway during asthma and defects ... inflammation resolution is an active process orchestrated by specific chemical mediators that are elaborated ... of pro-resolving chemical mediators and provide examples of select mediators and their structural analogs ...
| Abstract | Asthma pathobiology is remarkable for chronic airway inflammation that fails to spontaneously resolve. No curative therapy is currently available. A growing body of evidence indicates that, in health, inflammation resolution is an active process orchestrated by specific chemical mediators that are elaborated to restore tissue homeostasis. Activated cell membranes release polyunsaturated fatty acids from phospholipids for enzymatic conversion to biologically active mediators with profound regulatory effects on innate and adaptive immunity. Some of these mediators carry anti-inflammatory and pro-resolving actions that are transduced in a cell-type specific manner via specific recognition sites that initiate regulatory intracellular signals, such as presqualene diphosphate remodeling, to limit pro-phlogistic cell activation. Some of these counter-regulatory lipid mediators have been identified in the airway during asthma and defects in their production are associated with disease severity. In this review, we describe the biosynthesis and bioactions of pro-resolving chemical mediators and provide examples of select mediators and their structural analogs with particular relevance to asthma. |
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| MeSH term(s) | Animals ; Biomimetics/trends ; CD59 Antigens/metabolism ; CD59 Antigens/therapeutic use ; Diet ; Eicosapentaenoic Acid/analogs & derivatives ; Eicosapentaenoic Acid/genetics ; Eicosapentaenoic Acid/metabolism ; Feedback, Physiological ; Fish Oils/metabolism ; Guinea Pigs ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/isolation & purification ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/metabolism ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use ; Lipid Metabolism/immunology ; Lipoxins/genetics ; Lipoxins/metabolism ; Mice ; Polyisoprenyl Phosphates/metabolism ; Polyisoprenyl Phosphates/therapeutic use ; Respiratory Hypersensitivity/diet therapy ; Respiratory Hypersensitivity/drug therapy ; Respiratory Hypersensitivity/immunology ; Respiratory Hypersensitivity/metabolism ; Signal Transduction/immunology | |||||
| Chemical Substances | CD59 Antigens ; Fish Oils ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Lipoxins ; Polyisoprenyl Phosphates ; presqualene pyrophosphate (29849-75-0) ; Eicosapentaenoic Acid (AAN7QOV9EA) ; 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid (GND3JH08JA) | |||||
| Language | English | |||||
| Publishing date | 2008-11-01 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 1336498-4 | |||||
| ISSN | 1440-1592 ; 1323-8930 | |||||
| ISSN (online) | 1440-1592 | |||||
| ISSN | 1323-8930 | |||||
| DOI | 10.2332/allergolint.08-RAI-0018 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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