Article ; Online: SARS CoV-2 infections in healthcare workers with a pre-existing T-cell response: a prospective cohort study.
2021 Volume 27, Issue 6, Page(s) 916.e1–916.e4
Abstract: ... A pre-existing T-cell response does not seem to reduce incident SARS-CoV-2 infections ... on incident SARS-CoV-2 infections.: Methods: This was a follow-up study of 38 seronegative healthcare ... infections (55%) occurred in HCWs with a pre-existing T-cell response (30% of those with a cellular response ...
Abstract | Objective: T-cell responses against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are observed in unexposed individuals. We evaluated the impact of this pre-existing cellular response on incident SARS-CoV-2 infections. Methods: This was a follow-up study of 38 seronegative healthcare workers (HCWs) with previous evaluation of CD8+ and CD4+ T-cell responses after stimulation with SARS-CoV-2 structural proteins. Infection was considered in the presence of a positive RT-PCR test and/or confirmed seroconversion. Results: Twenty of the 38 HCWs included (53%) had a previous specific CD8+ T-cell response to peptides encompassing the spike protein (S) in 13 (34%), the membrane (M) in 17 (45%), or/and the nucleocapsid (N) in three (8%). During a follow-up of 189 days (interquartile range (IQR) 172-195), 11 HCWs (29%) had an RT-PCR-positive test (n = 9) or seroconverted (n = 2). Median duration of symptoms was 2 days (IQR 0-7), and time to negative RT-PCR was 9 days (IQR 4-10). Notably, six incident infections (55%) occurred in HCWs with a pre-existing T-cell response (30% of those with a cellular response), who showed a significantly lower duration of symptoms (three were asymptomatic). Three of the six HCWs having a previous T-cell response continued to test seronegative. All the infected patients developed a robust T-cell response to different structural SARS-CoV-2 proteins, especially to protein S (91%). Conclusion: A pre-existing T-cell response does not seem to reduce incident SARS-CoV-2 infections, but it may contribute to asymptomatic or mild disease, rapid viral clearance and differences in seroconversion. |
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MeSH term(s) | Adult ; Antibodies, Viral ; COVID-19/immunology ; COVID-19 Nucleic Acid Testing ; Female ; Follow-Up Studies ; Health Personnel ; Humans ; Immunity ; Male ; Middle Aged ; Prospective Studies ; Seroconversion ; T-Lymphocytes/immunology ; Viral Structural Proteins/immunology ; Young Adult |
Chemical Substances | Antibodies, Viral ; Viral Structural Proteins |
Language | English |
Publishing date | 2021-03-02 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1328418-6 |
ISSN | 1469-0691 ; 1470-9465 ; 1198-743X |
ISSN (online) | 1469-0691 |
ISSN | 1470-9465 ; 1198-743X |
DOI | 10.1016/j.cmi.2021.02.020 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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