Article ; Online: Macrophage activation syndrome induced by A/H1N1 influenza in cystic fibrosis.
2014 Volume 49, Issue 2, Page(s) E10–2
Abstract: ... the case of a boy affected by CF who developed MAS triggered by pandemic H1N1 influenza; good clinical ... in the clinical status of CF patients. Macrophage activation syndrome (MAS) is a life-threatening complication ... This syndrome is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well ...
| Abstract | Bacterial respiratory infections have an important impact on the development and progression of pulmonary disease in cystic fibrosis (CF). Viral infections are possible triggers of acute deterioration in the clinical status of CF patients. Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic disease characterized by pancytopenia, hepatitis, hyperferritinemia, coagulopathy, and neurologic symptoms. This syndrome is thought to be caused by the activation and uncontrolled proliferation of T lymphocytes and well-differentiated macrophages, leading to widespread hemophagocytosis and cytokine overproduction. Here, we report the case of a boy affected by CF who developed MAS triggered by pandemic H1N1 influenza; good clinical response was obtained through high dose prednisone treatment. |
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| MeSH term(s) | Child ; Cystic Fibrosis/complications ; Humans ; Influenza A Virus, H1N1 Subtype/isolation & purification ; Influenza, Human/complications ; Influenza, Human/diagnosis ; Macrophage Activation Syndrome/diagnosis ; Macrophage Activation Syndrome/virology ; Male | |||||
| Language | English | |||||
| Publishing date | 2014-02 | |||||
| Publishing country | United States | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 632784-9 | |||||
| ISSN | 1099-0496 ; 8755-6863 | |||||
| ISSN (online) | 1099-0496 | |||||
| ISSN | 8755-6863 | |||||
| DOI | 10.1002/ppul.22778 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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