Article ; Online: Seroprevalence of SARS-CoV-2 in blood donors from the Lodi Red Zone and adjacent Lodi metropolitan and suburban area.
2021 Volume 27, Issue 6, Page(s) 914.e1–914.e4
Abstract: ... CoV-2) in blood donors (referred to the first lockdown area (Lodi Red-Zone) of the Lombardy region and ... in Lombardy Region and the neighbouring area were analysed for SARS-CoV-2 IgG-specific antibodies during ... March to 24 June, 1922 blood donors were tested for the presence of SARS-CoV-2 IgG showing a prevalence ...
Abstract | Objectives: To define the seroprevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in blood donors (referred to the first lockdown area (Lodi Red-Zone) of the Lombardy region and in a contiguous area that was not included in the first lockdown); to define the agreement between a commercial serological assay and a reference microneutralization assay; and to evaluate the persistence of SARS-CoV-2 neutralizing antibodies in a cohort of blood donors. Methods: Blood donors referred to the first lockdown area in Lombardy Region and the neighbouring area were analysed for SARS-CoV-2 IgG-specific antibodies during the period 18 March to 24 June 2020. Serum samples were analysed using both a chemiluminescent immunoassay (LIAISON® SARS-CoV-2 S1/S2 IgG, DiaSorin) for the quantitative characterization of SARS-CoV-2 anti-S1 and anti-S2 IgG antibodies and a neutralizing antibodies (NT-Abs) assay. Results: In the period from 18 March to 24 June, 1922 blood donors were tested for the presence of SARS-CoV-2 IgG showing a prevalence of 378/1922 (19.7%). A subgroup of 1139 blood donors were tested in parallel with a SARS-CoV-2 IgG assay and a microneutralization assay showing a prevalence of 22.2% and 21.6%, respectively. SARS-CoV-2 IgG quantification was correlated with NT-Abs titres. In 78.2% of participants the NT-Abs titre was maintained, but in 15.8% it decreased by one four-fold dilution and in 6.0% it increased by one four-fold dilution. Conclusions: The duration of immunity of SARS-CoV-2 is crucial for the course of the pandemic and for this reason the monitoring of NT Abs is important. Despite a stable NT-Abs titre being observed in the majority of blood donors, our findings need to be validated in a long-term period of follow up. |
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MeSH term(s) | Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; Blood Donors ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Testing ; Cohort Studies ; Communicable Disease Control ; Humans ; Immunoglobulin G/blood ; Italy/epidemiology ; Prevalence ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Seroepidemiologic Studies ; Serologic Tests |
Chemical Substances | Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin G |
Language | English |
Publishing date | 2021-03-04 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 1328418-6 |
ISSN | 1469-0691 ; 1470-9465 ; 1198-743X |
ISSN (online) | 1469-0691 |
ISSN | 1470-9465 ; 1198-743X |
DOI | 10.1016/j.cmi.2021.01.030 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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