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  1. Article ; Online: SARS-COV-2 infection presenting as ST-elevationmyocardial infarction.

    Castagna, Francesco / Cerrud-Rodriguez, Roberto / Villela, Miguel Alvarez / Bortnick, Anna E

    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

    2020  Volume 97, Issue 3, Page(s) E339–E342

    Abstract: ... of personnel. The diagnosis was complicated by two negative tests for SARS-COV-2, and high-clinical suspicion ... acute cardiogenic shock secondary to SARS-COV-2infection-patient zero presenting to our institution's ... We describe a patient presenting with chest discomfort, anterolateral ST elevation, and developing ...

    Abstract We describe a patient presenting with chest discomfort, anterolateral ST elevation, and developing acute cardiogenic shock secondary to SARS-COV-2infection-patient zero presenting to our institution's cardiac catheterization laboratory. The emergent presentation with limited clinical information led to exposure of personnel. The diagnosis was complicated by two negative tests for SARS-COV-2, and high-clinical suspicion from the patient's occupational history led to additional testing in order to confirm the diagnosis.
    MeSH term(s) COVID-19/complications ; COVID-19/diagnosis ; COVID-19/therapy ; Humans ; Male ; Middle Aged ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/therapy ; ST Elevation Myocardial Infarction/virology ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/therapy ; Shock, Cardiogenic/virology
    Keywords covid19
    Language English
    Publishing date 2020-05-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1459995-8
    ISSN 1522-726X ; 1522-1946
    ISSN (online) 1522-726X
    ISSN 1522-1946
    DOI 10.1002/ccd.28974
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: SARS-COV-2 infection presenting as ST-elevationmyocardial infarction

    Castagna, Francesco / Cerrud-Rodriguez, Roberto / Villela, Miguel Alvarez / Bortnick, Anna E

    Catheter. cardiovasc. interv

    Abstract: ... of personnel. The diagnosis was complicated by two negative tests for SARS-COV-2, and high-clinical suspicion ... acute cardiogenic shock secondary to SARS-COV-2infection-patient zero presenting to our institution's ... We describe a patient presenting with chest discomfort, anterolateral ST elevation, and developing ...

    Abstract We describe a patient presenting with chest discomfort, anterolateral ST elevation, and developing acute cardiogenic shock secondary to SARS-COV-2infection-patient zero presenting to our institution's cardiac catheterization laboratory. The emergent presentation with limited clinical information led to exposure of personnel. The diagnosis was complicated by two negative tests for SARS-COV-2, and high-clinical suspicion from the patient's occupational history led to additional testing in order to confirm the diagnosis.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32473085
    Database COVID19

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  3. Article ; Online: SARS-COV-2 colonizes coronary thrombus and impairs heart microcirculation bed in asymptomatic SARS-CoV-2 positive subjects with acute myocardial infarction.

    Marfella, Raffaele / Paolisso, Pasquale / Sardu, Celestino / Palomba, Luciana / D'Onofrio, Nunzia / Cesaro, Arturo / Barbieri, Michelangela / Rizzo, Maria Rosaria / Sasso, Ferdinando Carlo / Scisciola, Lucia / Turriziani, Fabrizio / Galdiero, Massimiliano / Pignataro, Danilo / Minicucci, Fabio / Trotta, Maria Consiglia / D'Amico, Michele / Mauro, Ciro / Calabrò, Paolo / Balestrieri, Maria Luisa /
    Signioriello, Giuseppe / Barbato, Emanuele / Galdiero, Marilena / Paolisso, Giuseppe

    Critical care (London, England)

    2021  Volume 25, Issue 1, Page(s) 217

    Abstract: ... Thus, multiple logistic regression analyses evidenced that thrombus SARS-CoV-2 infection and dimension were ... on microvascular bed perfusion in the infarct area (myocardial blush grade, MBG) in ASAP compared to SARS-COV-2 ... and 39 (84.9%) of ASAP patients had thrombus specimens positive for SARS-COV-2. After PPCI, a MBG 2-3 ...

    Abstract Background: The viral load of asymptomatic SAR-COV-2 positive (ASAP) persons has been equal to that of symptomatic patients. On the other hand, there are no reports of ST-elevation myocardial infarction (STEMI) outcomes in ASAP patients. Therefore, we evaluated thrombus burden and thrombus viral load and their impact on microvascular bed perfusion in the infarct area (myocardial blush grade, MBG) in ASAP compared to SARS-COV-2 negative (SANE) STEMI patients.
    Methods: This was an observational study of 46 ASAP, and 130 SANE patients admitted with confirmed STEMI treated with primary percutaneous coronary intervention and thrombus aspiration. The primary endpoints were thrombus dimension + thrombus viral load effects on MBG after PPCI. The secondary endpoints during hospitalization were major adverse cardiovascular events (MACEs). MACEs are defined as a composite of cardiovascular death, nonfatal acute AMI, and heart failure during hospitalization.
    Results: In the study population, ASAP vs. SANE showed a significant greater use of GP IIb/IIIa inhibitors and of heparin (p < 0.05), and a higher thrombus grade 5 and thrombus dimensions (p < 0.05). Interestingly, ASAP vs. SANE patients had lower MBG and left ventricular function (p < 0.001), and 39 (84.9%) of ASAP patients had thrombus specimens positive for SARS-COV-2. After PPCI, a MBG 2-3 was present in only 26.1% of ASAP vs. 97.7% of SANE STEMI patients (p < 0.001). Notably, death and nonfatal AMI were higher in ASAP vs. SANE patients (p < 0.05). Finally, in ASAP STEMI patients the thrombus viral load was a significant determinant of thrombus dimension independently of risk factors (p < 0.005). Thus, multiple logistic regression analyses evidenced that thrombus SARS-CoV-2 infection and dimension were significant predictors of poorer MBG in STEMI patients. Intriguingly, in ASAP patients the female vs. male had higher thrombus viral load (15.53 ± 4.5 vs. 30.25 ± 5.51 CT; p < 0.001), and thrombus dimension (4.62 ± 0.44 vs 4.00 ± 1.28 mm
    Conclusions: In ASAP patients presenting with STEMI, there is strong evidence towards higher thrombus viral load, dimension, and poorer MBG. These data support the need to reconsider ASAP status as a risk factor that may worsen STEMI outcomes.
    MeSH term(s) Aged ; Analysis of Variance ; Asymptomatic Infections/epidemiology ; COVID-19/complications ; COVID-19/epidemiology ; Cohort Studies ; Coronary Angiography/methods ; Coronary Thrombosis/epidemiology ; Coronary Thrombosis/virology ; Echocardiography/methods ; Female ; Heart/physiopathology ; Humans ; Kaplan-Meier Estimate ; Male ; Microcirculation/physiology ; Middle Aged ; Myocardial Infarction/epidemiology ; Myocardial Infarction/physiopathology
    Language English
    Publishing date 2021-06-24
    Publishing country England
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-021-03643-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5517: Show issues Location:
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  4. Article: Undiagnosed SARS-CoV-2 infection and outcome in patients with acute MI and no COVID-19 symptoms.

    Akhtar, Zubair / Chowdhury, Fahmida / Aleem, Mohammad Abdul / Ghosh, Probir Kumar / Rahman, Mahmudur / Rahman, Mustafizur / Hossain, Mohammad Enayet / Sumiya, Mariya Kibtiya / Islam, A K M Monwarul / Uddin, Mir Jamal / MacIntyre, C Raina / Cajander, Sara / Frobert, Ole

    Open heart

    2021  Volume 8, Issue 1

    Abstract: Objective: We aimed to determine the prevalence and outcome of occult infection with SARS-CoV-2 ... 378).: Conclusion: We found a substantial rate of occult SARS-CoV-2 infection in the studied cohort ... collected by nasopharyngeal swab to test for SARS-CoV-2 and influenza virus by real-time ...

    Abstract Objective: We aimed to determine the prevalence and outcome of occult infection with SARS-CoV-2 and influenza in patients presenting with myocardial infarction (MI) without COVID-19 symptoms.
    Methods: We conducted an observational study from 28 June to 11 August 2020, enrolling patients admitted to the National Institute of Cardiovascular Disease Hospital, Dhaka, Bangladesh, with ST-segment elevation MI (STEMI) or non-ST-segment elevation MI who did not meet WHO criteria for suspected COVID-19. Samples were collected by nasopharyngeal swab to test for SARS-CoV-2 and influenza virus by real-time reverse transcriptase PCR. We followed up patients at 3 months (13 weeks) postadmission to record adverse cardiovascular outcomes: all-cause death, new MI, heart failure and new percutaneous coronary intervention or stent thrombosis. Survival analysis was performed using the Kaplan-Meier method.
    Results: We enrolled 280 patients with MI, 79% male, mean age 54.5±11.8 years, 140 of whom were diagnosed with STEMI. We found 36 (13%) to be infected with SARS-CoV-2 and 1 with influenza. There was no significant difference between mortality rate observed among SARS-CoV-2 infected patients compared with non-infected (5 (14%) vs 26 (11%); p=0.564). A numerically shorter median time to a recurrent cardiovascular event was recorded among SARS-CoV-2 infected compared with non-infected patients (21 days, IQR: 8-46 vs 27 days, IQR: 7-44; p=0.378).
    Conclusion: We found a substantial rate of occult SARS-CoV-2 infection in the studied cohort, suggesting SARS-CoV-2 may precipitate MI. Asymptomatic patients with COVID-19 admitted with MI may contribute to disease transmission and warrants widespread testing of hospital admissions.
    MeSH term(s) Adult ; Aged ; Bangladesh/epidemiology ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/mortality ; Disease Progression ; Female ; Hospitalization ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Non-ST Elevated Myocardial Infarction/diagnosis ; Non-ST Elevated Myocardial Infarction/epidemiology ; Non-ST Elevated Myocardial Infarction/mortality ; Non-ST Elevated Myocardial Infarction/therapy ; Predictive Value of Tests ; Prevalence ; Prognosis ; Prospective Studies ; Recurrence ; Risk Assessment ; Risk Factors ; ST Elevation Myocardial Infarction/diagnosis ; ST Elevation Myocardial Infarction/epidemiology ; ST Elevation Myocardial Infarction/mortality ; ST Elevation Myocardial Infarction/therapy ; Time Factors ; Undiagnosed Diseases
    Language English
    Publishing date 2021-04-02
    Publishing country England
    Document type Comparative Study ; Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2747269-3
    ISSN 2053-3624
    ISSN 2053-3624
    DOI 10.1136/openhrt-2021-001617
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  5. Article ; Online: Care of acute coronary syndromes during the health contingency due to a SARS-CoV-2 outbreak.

    Piña-Reyna, Yigal / García-Rincón, Andrés / Ortiz-Fernández P, Patricio H / Alcocer-Gamba, Marco A / Gutiérrez-Fajardo, Pedro / Merino-Rajme, José A / Reyes-Terán, Gustavo

    Archivos de cardiologia de Mexico

    2020  Volume 90, Issue Supl, Page(s) 33–35

    Abstract: ... with an acute myocardial infarction with ST-segment elevation (IAMCESST), it has been suggested to favor ... the best treatment strategy in patients with acute coronary syndrome (SICA). In patients presenting ...

    Title translation Atención de los síndromes coronarios agudos durante la contingencia sanitaria por brote de SARS-CoV-2.
    Abstract The communications accumulated in the last weeks make it clear that there is no agreement to define the best treatment strategy in patients with acute coronary syndrome (SICA). In patients presenting with an acute myocardial infarction with ST-segment elevation (IAMCESST), it has been suggested to favor fibrinolysis (FL) over primary percutaneous coronary intervention (PCI), reserving ICP for cases of failed FL
    MeSH term(s) Acute Coronary Syndrome/physiopathology ; Acute Coronary Syndrome/therapy ; COVID-19 ; Cardiac Catheterization ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Disease Outbreaks ; Humans ; Mexico/epidemiology ; Non-ST Elevated Myocardial Infarction/physiopathology ; Non-ST Elevated Myocardial Infarction/therapy ; Pandemics/prevention & control ; Percutaneous Coronary Intervention/methods ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; ST Elevation Myocardial Infarction/physiopathology ; ST Elevation Myocardial Infarction/therapy
    Keywords covid19
    Language English
    Publishing date 2020-06-10
    Publishing country Mexico
    Document type Journal Article
    ISSN 1665-1731
    ISSN (online) 1665-1731
    DOI 10.24875/ACM.M20000062
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  6. Article ; Online: Comparison of Coronary Artery Involvement and Mortality in STEMI Patients With and Without SARS-CoV-2 During the COVID-19 Pandemic: A Systematic Review and Meta-Analysis.

    Thakker, Ravi A / Elbadawi, Ayman / Chatila, Khaled F / Goel, Sachin S / Reynoso, David / Berbarie, Rafic F / Gilani, Syed / Rangasetty, Umamahesh / Khalife, Wissam

    Current problems in cardiology

    2021  Volume 47, Issue 3, Page(s) 101032

    Abstract: Background: Cardiovascular injury with SARS-CoV-2 infection is well known. Several studies have ... outlined baseline characteristics in patients presenting with STEMI and SARS-CoV-2. Paucity in data exists ... in selective coronary involvement in patients with STEMI and SARS-CoV-2 during the COVID-19 pandemic ...

    Abstract Background: Cardiovascular injury with SARS-CoV-2 infection is well known. Several studies have outlined baseline characteristics in patients presenting with STEMI and SARS-CoV-2. Paucity in data exists in selective coronary involvement in patients with STEMI and SARS-CoV-2 during the COVID-19 pandemic.
    Methods: A systematic search and meta-analysis of studies meeting the inclusion and exclusion criteria obtained from MEDLINE, Scopus, and Cochrane databases was performed utilizing PRISMA criteria. The main outcome was likelihood of coronary artery involvement among patients with STEMI and SARS-CoV-2 versus without SARS-CoV-2. The primary adverse outcome measured was in-hospital mortality.
    Results: The final analysis included 5 observational studies with a total of 2,266 patients. There was no statistical significance in LM (OR 1.40; 95% CI: 0.68, 2.90), LAD (OR 1.09; 95% CI 0.83, 1.43), LCX (OR 1.17; 95% CI: 0.75, 1.85), or RCA (OR 0.59; 95% CI: 0.30, 1.17) disease among the 2 groups. LAD disease was the most prevalent coronary involvement among patients with STEMI and SARS-CoV-2 (49.6%). Higher in-hospital mortality was observed in the STEMI and SARS-CoV-2 group (OR 5.24; 95% CI: 3.63, 7.56).
    Conclusions: Our analysis demonstrated no statistical significance in selective coronary involvement in patients with STEMI and SARS-CoV-2 during the COVID-19 pandemic. The higher mortality among patients with SARS-CoV-2 and STEMI has been noted in prior studies with concerns being late presentation due to fear of infection, delayed care time, and poor resource allocation. Focus should be placed on identifying and managing comorbidities to reduce mortality.
    MeSH term(s) COVID-19 ; Coronary Vessels ; Humans ; Pandemics ; Percutaneous Coronary Intervention ; SARS-CoV-2 ; ST Elevation Myocardial Infarction/epidemiology
    Language English
    Publishing date 2021-10-28
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 441230-8
    ISSN 1535-6280 ; 0146-2806
    ISSN (online) 1535-6280
    ISSN 0146-2806
    DOI 10.1016/j.cpcardiol.2021.101032
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