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Article ; Online: Breast Cancer Care in a COVID-19 Pandemic Epicenter.

Castaldi, Maria / Latifi, Rifat

2020 Volume 86, Issue 11, Page(s) 1513–1514

MeSH term(s)	Breast Neoplasms/embryology ; Breast Neoplasms/therapy ; COVID-19/epidemiology ; Comorbidity ; Disease Management ; Global Health ; Humans ; Incidence ; Pandemics ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-01
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820952338
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Article: Breast Cancer Care in a COVID-19 Pandemic Epicenter

Castaldi, Maria / Latifi, Rifat

Am Surg

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #901584
Database	COVID19

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Article ; Online: Breast Cancer Care in a COVID-19 Pandemic Epicenter

Castaldi, Maria / Latifi, Rifat

The American Surgeon

2020 , Page(s) 313482095233

Keywords	General Medicine ; covid19
Language	English
Publisher	SAGE Publications
Publishing country	us
Document type	Article ; Online
ZDB-ID	202465-2
ISSN	1555-9823 ; 0003-1348
ISSN (online)	1555-9823
ISSN	0003-1348
DOI	10.1177/0003134820952338
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Breast reconstruction during the COVID-19 pandemic: Single institution experience from the pandemic's epicenter in the United States.

Boyd, Carter J / Hemal, Kshipra / Ramesh, Sruthi / Bekisz, Jonathan M / Salibian, Ara A / Thanik, Vishal / Levine, Jamie P / Choi, Mihye / Karp, Nolan S

Journal of plastic, reconstructive & aesthetic surgery : JPRAS

2022 Volume 75, Issue 7, Page(s) 2236–2241

Abstract: ... to that in 2020.: Conclusion: The COVID-19 pandemic reduced the volume of breast cancer surveillance, surgical ... of breast cancer care. The objective of this study was to quantify the effect of the pandemic on breast ... Introduction: The coronavirus disease-19 (COVID-19) pandemic dramatically changed the delivery ...

Abstract	Introduction: The coronavirus disease-19 (COVID-19) pandemic dramatically changed the delivery of breast cancer care. The objective of this study was to quantify the effect of the pandemic on breast cancer screening, treatment, and reconstruction at a single institution in New York City. Methods: A retrospective chart review was conducted to determine the number of mammograms, lumpectomies, mastectomies, and breast reconstruction operations performed between January 1, 2019 and June 30, 2021. Outcomes analyzed included changes in mammography, oncologic surgery, and breast reconstruction surgery volume before, during and after the start of the pandemic. Results: Mammography volume declined by 11% in March-May of 2020. Oncologic breast surgeries and reconstructive surgeries similarly declined by 6.8% and 11%, respectively, in 2020 compared with 2019, reaching their lowest levels in April 2020. The volume of all procedures increased during the summer of 2020. Mammography volumes in June and July 2020 were found to be at pre-COVID levels, and in October-December 2020 were 15% higher than in 2019. Oncologic breast surgeries saw a similar rebound in May 2020, with 24.6% more cases performed compared with May 2019. Breast reconstruction volumes increased, though changes in the types of reconstruction were noted. Oncoplastic closures were more common during the pandemic, while two-stage implant reconstruction and immediate autologous reconstruction decreased by 27% and 43%, respectively. All procedures are on track to increase in volume in 2021 compared to that in 2020. Conclusion: The COVID-19 pandemic reduced the volume of breast cancer surveillance, surgical treatment, and reconstruction procedures. While it is reassuring that volumes have rebounded in 2021, efforts must be made to emphasize screening and treatment procedures in the face of subsequent surges, such as that recently attributable to the Delta and Omicron variants.
MeSH term(s)	Breast Neoplasms/epidemiology ; Breast Neoplasms/surgery ; COVID-19/epidemiology ; Female ; Humans ; Mammaplasty/methods ; Pandemics/prevention & control ; Retrospective Studies ; SARS-CoV-2 ; United States
Language	English
Publishing date	2022-02-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2217750-4
ISSN	1878-0539 ; 1748-6815 ; 0007-1226
ISSN (online)	1878-0539
ISSN	1748-6815 ; 0007-1226
DOI	10.1016/j.bjps.2022.02.021
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Article ; Online: Management of Breast Cancer Patients During the Coronavirus Disease 2019 Pandemic: The Experience From the Epicenter of China, Wuhan.

Zhou, Jun / Liu, Yuyin / Xu, Ming / Mei, Li / Ruan, Shengnan / Zhang, Ning / Yi, Pengfei / Chen, Qianzhi / Tan, Jie

Clinical breast cancer

2021 Volume 22, Issue 1, Page(s) e1–e7

Abstract: ... procedures for patients with breast cancer, leading to the delay or interruption of anticancer therapies ... Patients and methods: To better serve patients with breast cancer under the premise of epidemic control ... and treatment process of patients with breast cancer in our center during the coronavirus disease 2019 ...

Abstract	Background: The coronavirus disease 2019 pandemic is a global public health event. Wuhan used to be the epicenter of China and finally controlled the outbreak through city lockdown and many other policies. However, the pandemic and the prevention strategies had a huge impact on the medical care procedures for patients with breast cancer, leading to the delay or interruption of anticancer therapies. Patients and methods: To better serve patients with breast cancer under the premise of epidemic control, many strategies have been proposed and optimized in our center. One of the most important parts of these strategies is the promotion of telemedicine, including online consultation, online prescription, and drug mailing services. Results: In keeping with the city and hospital policies, we have also introduced stricter ward management policies and more precise care. Conclusion: Here, we collected the diagnosis and treatment process of patients with breast cancer in our center during the coronavirus disease 2019 pandemic, which was found to be correlated to a reduction in chemotherapy-related myelosuppression and hepatic dysfunction, hoping to provide a reference for other cancer centers that may suffer from the similar situation.
MeSH term(s)	Adult ; Aged ; Antineoplastic Agents/adverse effects ; Bone Marrow/drug effects ; Breast Neoplasms/diagnosis ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; COVID-19/epidemiology ; Chemical and Drug Induced Liver Injury/etiology ; China/epidemiology ; Female ; Humans ; Middle Aged ; SARS-CoV-2 ; Telemedicine
Chemical Substances	Antineoplastic Agents
Language	English
Publishing date	2021-05-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2106734-X
ISSN	1938-0666 ; 1526-8209
ISSN (online)	1938-0666
ISSN	1526-8209
DOI	10.1016/j.clbc.2021.04.014
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Zs.A 5800: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: COVID-19 Pandemic: Changes in Care for a Community Academic Breast Center and Patient Perception of Those Changes.

Kennard, Kaitlyn / Williams, Austin D / Goldblatt, Lindsay G / Buckley, Meghan E / Bruce, Laura / Larson, Sharon / Carter, William B / Lamb, Elena P / Carp, Ned Z / Sizer, Lina M / Frazier, Thomas G

Annals of surgical oncology

2021 Volume 28, Issue 9, Page(s) 5071–5081

Abstract: ... the initial phase of the COVID-19 pandemic. 44% of patients experienced a change in breast cancer care due ... Accordingly, alterations were made in breast cancer care at a community hospital.: Methods: The authors ... A prospective database captured changes in breast cancer care at a community academic breast center during ...

Abstract	Background: Philadelphia and its suburbs were an epicenter for the initial COVID-19 outbreak. Accordingly, alterations were made in breast cancer care at a community hospital. Methods: The authors developed a prospective database of all the patients with invasive or in situ breast cancer between March 1 and June 15 at their breast center. Any change in a breast cancer plan due to the pandemic was documented, and the patients were grouped into two cohorts according to whether a change was made (CTX) or no change was made (NC) in their care. The patients were asked a series of questions about their care, including those in the Generalized Anxiety Disorder two-item questionnaire (GAD-2), via telephone. Results: The study enrolled 73 patients: 41 NC patients (56%) and 32 CTX patients (44%). The two cohorts did not differ in terms of age, race, or stage. Changes included delay in therapy (15.1%) and use of neoadjuvant endocrine therapy (NET, 28.8%). The median time to surgery was 24 days (interequartile range [IQR], 16-45 days) for the NC patients and 82 day s (IQR, 52-98 days) for the CTX patients (p ≤ 0.001). The median duration of NET was 78 days. The GAD-2 showed anxiety positivity to be 29.6% for the CTX patients and 32.4% for the NC patients (p = 1.00). More than half (55.6%) of the CTX patients believed COVID-19 affected their treatment outlook compared with 25.7% of the NC patients (p = 0.021). Conclusions: A prospective database captured changes in breast cancer care at a community academic breast center during the initial phase of the COVID-19 pandemic. 44% of patients experienced a change in breast cancer care due to COVID-19. The same level of anxiety and depression was seen in both change in therapy (CTX) and no change (NC). 55.6% of CTX cohort believed COVID-19 affected their treatment outlook.
MeSH term(s)	Anxiety ; COVID-19 ; Humans ; Pandemics ; Perception ; SARS-CoV-2
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	1200469-8
ISSN	1534-4681 ; 1068-9265
ISSN (online)	1534-4681
ISSN	1068-9265
DOI	10.1245/s10434-020-09583-3
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Article ; Online: Personalized Risk-Benefit Ratio Adaptation of Breast Cancer Care at the Epicenter of COVID-19 Outbreak.

Viale, Giulia / Licata, Luca / Sica, Lorenzo / Zambelli, Stefania / Zucchinelli, Patrizia / Rognone, Alessia / Aldrighetti, Daniela / Di Micco, Rosa / Zuber, Veronica / Pasetti, Marcella / Di Muzio, Nadia / Rodighiero, Mariagrazia / Panizza, Pietro / Sassi, Isabella / Petrella, Giovanna / Cascinu, Stefano / Gentilini, Oreste Davide / Bianchini, Giampaolo

The oncologist

2020 Volume 25, Issue 7, Page(s) e1013–e1020

Abstract: ... patients with breast cancer during the COVID-19 outbreak is challenging. The present work highlights ... from the beginning of the COVID-19 outbreak to ensure the continuum of the best possible cancer care for our patients ... of most of the available health care resources to treat COVID-19-positive patients, generating ...

Abstract	Northern Italy has been one of the European regions reporting the highest number of COVID-19 cases and deaths. The pandemic spread has challenged the National Health System, requiring reallocation of most of the available health care resources to treat COVID-19-positive patients, generating a competition with other health care needs, including cancer. Patients with cancer are at higher risk of developing critical illness after COVID-19 infection. Thus, mitigation strategies should be adopted to reduce the likelihood of infection in all patients with cancer. At the same time, suboptimal care and treatments may result in worse cancer-related outcome. In this article, we attempt to estimate the individual risk-benefit balance to define personalized strategies for optimal breast cancer management, avoiding as much as possible a general untailored approach. We discuss and report the strategies our Breast Unit adopted from the beginning of the COVID-19 outbreak to ensure the continuum of the best possible cancer care for our patients while mitigating the risk of infection, despite limited health care resources. IMPLICATIONS FOR PRACTICE: Managing patients with breast cancer during the COVID-19 outbreak is challenging. The present work highlights the need to estimate the individual patient risk of infection, which depends on both epidemiological considerations and individual clinical characteristics. The management of patients with breast cancer should be adapted and personalized according to the balance between COVID-19-related risk and the expected benefit of treatments. This work also provides useful suggestions on the modality of patient triage, the conduct of clinical trials, the management of an oncologic team, and the approach to patients' and health workers' psychological distress.
MeSH term(s)	Adult ; Age Factors ; Aged ; Betacoronavirus/pathogenicity ; Breast Neoplasms/therapy ; COVID-19 ; Clinical Trials as Topic/organization & administration ; Clinical Trials as Topic/standards ; Continuity of Patient Care/organization & administration ; Continuity of Patient Care/standards ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Female ; Humans ; Infection Control/organization & administration ; Infection Control/standards ; Italy/epidemiology ; Medical Oncology/organization & administration ; Medical Oncology/standards ; Middle Aged ; Pandemics/prevention & control ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; Research Design/standards ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Telemedicine/organization & administration ; Telemedicine/standards
Keywords	covid19
Language	English
Publishing date	2020-05-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1634/theoncologist.2020-0316
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Article ; Online: Protocol for a Systematic Review Assessing Surgery versus Primary Endocrine Therapy in Operable Breast Cancer. Prep for Pandemic.

Roberts, Sacha / Rojas, Aram / Gachabayov, Mahir / Castaldi, Maria

International journal of surgery protocols

2020 Volume 24, Page(s) 36–38

Abstract: Introduction: In COVID-19 pandemic epicenters cancer care was severely impacted. All elective and ... and protect patients and staff from SARS-CoV-2 exposure. Structured decision making for breast cancer ... for elective breast cancer procedures after mitigation is a challenge for prioritization.: Objective and ...

Abstract	Introduction: In COVID-19 pandemic epicenters cancer care was severely impacted. All elective and semi-elective procedures, as well as select urgent cases, were postponed in order to preserve resources and protect patients and staff from SARS-CoV-2 exposure. Structured decision making for breast cancer treatment resulted in deferment of surgery with initiation of endocrine therapy. Moreover, the waitlist for elective breast cancer procedures after mitigation is a challenge for prioritization. Objective and significance: We aim to summarize the current body of evidence, comparatively evaluate oncological outcomes of surgery versus primary endocrine therapy (PET), and determine whether PET is a viable long Methods and analysis: The database search includes PubMed, EMBASE, and MEDLINE (via Ovid). This systematic review includes women 18 years or older undergoing one of two interventions for HRP breast cancer: surgery (with or without endocrine therapy post-surgery) or solely PET. Studies comparing one of the two interventions of interest to a non-relevant intervention and studies reporting only descriptive data will not be included in the quantitative synthesis of data. After selection of eligible studies based on title and abstract, these studies will be further screened through full text articles by two independent reviewers, with a third as an arbitrator. Eligible studies will be critically appraised at the study level for methodological quality. Cochrane methodology will be utilized for meta-analysis. Ethics and dissemination: This study does not require an institutional review board approval given its summary design nature. Findings of this systematic review will be published in a peer-reviewed journal.
Language	English
Publishing date	2020-11-05
Publishing country	England
Document type	Journal Article
ISSN	2468-3574
ISSN (online)	2468-3574
DOI	10.1016/j.isjp.2020.10.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Personalized Risk-Benefit Ratio Adaptation of Breast Cancer Care at the Epicenter of COVID-19 Outbreak

Oncologist

Abstract	Northern Italy has been one of the European regions reporting the highest number of COVID-19 cases and deaths. The pandemic spread has challenged the National Health System, requiring reallocation of most of the available health care resources to treat COVID-19-positive patients, generating a competition with other health care needs, including cancer. Patients with cancer are at higher risk of developing critical illness after COVID-19 infection. Thus, mitigation strategies should be adopted to reduce the likelihood of infection in all patients with cancer. At the same time, suboptimal care and treatments may result in worse cancer-related outcome. In this article, we attempt to estimate the individual risk-benefit balance to define personalized strategies for optimal breast cancer management, avoiding as much as possible a general untailored approach. We discuss and report the strategies our Breast Unit adopted from the beginning of the COVID-19 outbreak to ensure the continuum of the best possible cancer care for our patients while mitigating the risk of infection, despite limited health care resources. IMPLICATIONS FOR PRACTICE: Managing patients with breast cancer during the COVID-19 outbreak is challenging. The present work highlights the need to estimate the individual patient risk of infection, which depends on both epidemiological considerations and individual clinical characteristics. The management of patients with breast cancer should be adapted and personalized according to the balance between COVID-19-related risk and the expected benefit of treatments. This work also provides useful suggestions on the modality of patient triage, the conduct of clinical trials, the management of an oncologic team, and the approach to patients' and health workers' psychological distress.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #506429
Database	COVID19

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