Article: MK2: an unrecognized regulator of tumor promoting macrophages in colorectal cancer?
Macrophage
2016 Volume 3
Abstract: ... as a regulator of macrophages during colitis-associated CRC (CAC). MK2 is a proinflammatory kinase that promotes ... through activation of proinflammatory immune cell phenotypes. In cancer, both M1 and M2 macrophages participate ... with inflammation before and after development. Macrophages promote colitis and colitis-associated CRC. M1 ...
| Abstract | Colorectal cancer (CRC) is one of the most common malignancies and is associated closely with inflammation before and after development. Macrophages promote colitis and colitis-associated CRC. M1 macrophages contribute to colitis directly through the production of proinflammatory cytokines and through activation of proinflammatory immune cell phenotypes. In cancer, both M1 and M2 macrophages participate in tumor development and progression through cytokine production, changes in cell signaling and activation of T cells. We have identified the mitogen-activated protein kinase-activated protein kinase 2 (MK2) as a regulator of macrophages during colitis-associated CRC (CAC). MK2 is a proinflammatory kinase that promotes production of IL-1α, IL-1β, IL-6 and TNF-α. MK2 |
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| Language | English |
| Publishing date | 2016-02-01 |
| Publishing country | United States |
| Document type | Journal Article |
| ISSN | 2378-136X |
| ISSN | 2378-136X |
| DOI | 10.14800/macrophage.1166 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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