Article ; Online: Eosinopenia is a reliable marker of severe disease and unfavourable outcome in patients with COVID-19 pneumonia.
International journal of clinical practice
2021 Volume 75, Issue 7, Page(s) e14047
Abstract: ... in patients with COVID-19 pneumonia and might be used as a marker to discriminate patients with unfavourable ... the characteristics and clinical outcomes of patients with COVID-19 pneumonia and eosinopenia.: Methods: We revised ... discharge.: Results: Out of first 107 consecutive patients with pneumonia and a positive COVID-19 ...
| Abstract | Background and aim: Viral pneumonia is the most relevant clinical presentation of COVID-19 which may lead to severe acute respiratory syndrome and even death. Eosinopenia was often noticed in patients with COVID-19 pneumonia, but its role is poorly investigated. The aim of the present study was to investigate the characteristics and clinical outcomes of patients with COVID-19 pneumonia and eosinopenia. Methods: We revised the records of consecutive patients with COVID-19 pneumonia admitted to our ER-COVID-19 area in order to compare clinical characteristics and outcomes of patients with and without eosinopenia. We considered the following clinical outcomes: 4-weeks survival; need for intensive respiratory support; and hospital discharge. Results: Out of first 107 consecutive patients with pneumonia and a positive COVID-19 nasopharyngeal swab, 75 patients showed undetectable eosinophil count (absolute eosinopenia). At 4 weeks, 38 patients (38.4%) had required intensive respiratory treatment, 25 (23.4%) deceased and 42 (39.2%) were discharged. Compared with patients without absolute eosinopenia, patients with absolute eosinopenia showed higher need of intensive respiratory treatment (49.3% vs 13.3%, P < .001), higher mortality (30.6% vs 6.2%, P .006) and lower rate of hospital discharge (28% vs 65.6%, P < .001). Binary logistic regression analyses including neutrophil, lymphocyte, eosinophil, basophil and monocyte counts showed that absolute eosinopenia was an independent factor associated with 4-weeks mortality, need for intensive respiratory support and hospital discharge. Conclusions: Absolute eosinopenia is associated with clinical outcomes in patients with COVID-19 pneumonia and might be used as a marker to discriminate patients with unfavourable prognosis. |
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| MeSH term(s) | COVID-19 ; Eosinophils ; Humans ; Leukocyte Count ; Pneumonia, Viral ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-02-05 | |||||
| Publishing country | India | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1386246-7 | |||||
| ISSN | 1742-1241 ; 1368-5031 | |||||
| ISSN (online) | 1742-1241 | |||||
| ISSN | 1368-5031 | |||||
| DOI | 10.1111/ijcp.14047 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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