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  1. TI=Multiorgan thrombosis as a complication of COVID 19 pneumonia
  2. AU=Besho Merga

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  1. Artikel ; Online: Multiorgan thrombosis as a complication of COVID-19 pneumonia.

    Ceci Bonello, Etienne / Casha, Ramon / Xerri, Thelma / Bonello, John / Fsadni, Claudia / Mallia Azzopardi, Charles

    BMJ case reports

    2021  Band 14, Heft 7

    Abstract: ... complicated by myocarditis on a background of COVID-19 pneumonia. He was medically treated for ACS; however, 3 ...

    Abstract A 47-year-old man, positive for SARS-CoV-2, was diagnosed with acute coronary syndrome (ACS) complicated by myocarditis on a background of COVID-19 pneumonia. He was medically treated for ACS; however, 3 days into his admission, the patient developed neurological complications confirmed on MRI of the brain. MRI showed established infarcts involving a large part of the left temporal lobe and right occipital lobe, with minor foci of micro-haemorrhagic transformation in the left temporal lobe. A left ventricular mural thrombus was then confirmed on echocardiogram, and this was attributed as the cause of his neurological infarct. Further infarctions in the kidneys and spleen, and thrombi in the superior mesenteric and left femoral artery were also identified on imaging of the abdomen. The left ventricular mural thrombus was removed surgically via a midline sternotomy incision under general anaesthesia. Surgery was successful and the patient was discharged to a rehabilitation centre.
    Mesh-Begriff(e) COVID-19 ; Echocardiography ; Humans ; Male ; Middle Aged ; Myocarditis ; SARS-CoV-2 ; Thrombosis/diagnostic imaging ; Thrombosis/etiology
    Sprache Englisch
    Erscheinungsdatum 2021-07-28
    Erscheinungsland England
    Dokumenttyp Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2021-243953
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: The case of complement activation in COVID-19 multiorgan impact.

    Noris, Marina / Benigni, Ariela / Remuzzi, Giuseppe

    Kidney international

    2020  Band 98, Heft 2, Seite(n) 314–322

    Abstract: ... products in the pathogenesis of COVID-19-associated tissue inflammation and thrombosis and propose ... The novel coronavirus disease COVID-19 originates in the lungs, but it may extend to other organs ... the relevance of this organ as a target of SARS-CoV-2 infection. COVID-19-associated tissue injury is not ...

    Abstract The novel coronavirus disease COVID-19 originates in the lungs, but it may extend to other organs, causing, in severe cases, multiorgan damage, including cardiac injury and acute kidney injury. In severe cases, the presence of kidney injury is associated with increased risk of death, highlighting the relevance of this organ as a target of SARS-CoV-2 infection. COVID-19-associated tissue injury is not primarily mediated by viral infection, but rather is a result of the inflammatory host immune response, which drives hypercytokinemia and aggressive inflammation that affect lung parenchymal cells, diminishing oxygen uptake, but also endothelial cells, resulting in endotheliitis and thrombotic events and intravascular coagulation. The complement system represents the first response of the host immune system to SARS-CoV-2 infection, but there is growing evidence that unrestrained activation of complement induced by the virus in the lungs and other organs plays a major role in acute and chronic inflammation, endothelial cell dysfunction, thrombus formation, and intravascular coagulation, and ultimately contributes to multiple organ failure and death. In this review, we discuss the relative role of the different complement activation products in the pathogenesis of COVID-19-associated tissue inflammation and thrombosis and propose the hypothesis that blockade of the terminal complement pathway may represent a potential therapeutic option for the prevention and treatment of lung and multiorgan damage.
    Mesh-Begriff(e) Animals ; Betacoronavirus ; COVID-19 ; Complement Activation ; Complement C5a/physiology ; Coronavirus Infections/complications ; Coronavirus Infections/immunology ; Endothelial Cells/physiology ; Humans ; Inflammation/etiology ; Mannose-Binding Lectin/physiology ; Mice ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Thrombosis/etiology ; Vascular Diseases/etiology
    Chemische Substanzen Mannose-Binding Lectin ; Complement C5a (80295-54-1)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-05-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2020.05.013
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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