Article: Human parvovirus B 19 and Epstein-Barr virus co-infection in a child with hereditary spherocytosis.
European review for medical and pharmacological sciences
2012 Volume 16, Issue 2, Page(s) 265–269
Abstract: ... Epstein Barr virus (EBV) infection also seems to share the same mechanism as HPV B19 in inducing bone marrow aplasia ... To our knowledge, this is the first report of a case of HPV B19 and EBV co-infection diagnosis in a paediatric ... We present a 7-year-old boy affected by hereditary spherocytosis (HS) who suffered from transient aplastic ...
| Abstract | Background: In patients with chronic congenital haemolytic disorders, human Parvovirus B19 (HPV B19) is frequently involved in pure red-cell aplastic crises. Furthermore, it may inhibit three-lineage haematopoiesis in the bone marrow, causing severe pancytopenia. In such patients, Epstein Barr virus (EBV) infection also seems to share the same mechanism as HPV B19 in inducing bone marrow aplasia, but at present the clinical effect of an infection sustained by both viruses is unknown. Clinical report: We present a 7-year-old boy affected by hereditary spherocytosis (HS) who suffered from transient aplastic crisis, in whom laboratory findings revealed a double HPV B19 and EBV infection. Conclusions: To our knowledge, this is the first report of a case of HPV B19 and EBV co-infection diagnosis in a paediatric patient. Despite underlying HS, no signs of haemolytic anaemia were detected, but the infection only produced transient pancytopenia. Nevertheless, the reason why there was no additive effect of the two viruses on the aplastic crisis is still unclear. |
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| MeSH term(s) | Anemia, Aplastic/etiology ; Child ; Coinfection ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/virology ; Herpesvirus 4, Human ; Humans ; Male ; Parvoviridae Infections/complications ; Parvoviridae Infections/virology ; Parvovirus B19, Human ; Spherocytosis, Hereditary/complications | |||||
| Language | English | |||||
| Publishing date | 2012-02 | |||||
| Publishing country | Italy | |||||
| Document type | Case Reports ; Journal Article | |||||
| ZDB-ID | 605550-3 | |||||
| ISSN | 2284-0729 ; 1128-3602 ; 0392-291X | |||||
| ISSN (online) | 2284-0729 | |||||
| ISSN | 1128-3602 ; 0392-291X | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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