Article ; Online: Surface contamination with nine antineoplastic drugs in 109 canadian centers; 10 years of a monitoring program.
2021 Volume 28, Issue 2, Page(s) 343–352
Abstract: ... monitoring is conducted once a year with voluntary Canadian centers, since 2010. Twelve standardized ... of the contamination of standardized sites of Canadian centers and a reduction in surface contamination from 2010 ... The limits of detection (in ng/cm: Results: The surfaces from 109 centers were sampled between 01/01/2020 ...
| Abstract | Introduction: Healthcare workers exposure to antineoplastic drugs can lead to adverse health effects. Guidelines promote the safe handling of antineoplastic drugs, but no safe exposure limit was determined. Regular surface sampling contributes to ensuring workers safety. Methods: A cross-sectional monitoring is conducted once a year with voluntary Canadian centers, since 2010. Twelve standardized sampling sites were sampled. Samples were analyzed by high performance mass coupled liquid chromatography. The limits of detection (in ng/cm Results: The surfaces from 109 centers were sampled between 01/01/2020-18/06/2020. Twenty-six centers delayed their participation because of the COVID-19 pandemic. 1217 samples were analyzed. Surfaces were frequently contaminated with cyclophosphamide (34% positive, 75th percentile 0.00165 ng/cm Conclusions: This large-scale study showed reproducible long term follow up of the contamination of standardized sites of Canadian centers and a reduction in surface contamination from 2010 to 2020. Periodic surface sampling help centers meet their continuous improvements goals to reduce exposure as much as possible. The COVID-19 pandemic had a limited impact on the program. |
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| MeSH term(s) | Antineoplastic Agents/analysis ; COVID-19 ; Canada ; Cross-Sectional Studies ; Cyclophosphamide/analysis ; Environmental Monitoring ; Equipment Contamination ; Humans ; Occupational Exposure/analysis ; Pandemics ; SARS-CoV-2 | |||||
| Chemical Substances | Antineoplastic Agents ; Cyclophosphamide (8N3DW7272P) | |||||
| Language | English | |||||
| Publishing date | 2021-02-10 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 1330764-2 | |||||
| ISSN | 1477-092X ; 1078-1552 | |||||
| ISSN (online) | 1477-092X | |||||
| ISSN | 1078-1552 | |||||
| DOI | 10.1177/1078155221992103 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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