Article ; Online: Myoclonus and cerebellar ataxia associated with COVID-19: a case report and systematic review.
2021 Volume 268, Issue 10, Page(s) 3517–3548
Abstract: ... we present a case and systematic review of myoclonus and cerebellar ataxia associated with COVID-19 ... 2019 to December 6, 2020.: Results: 51 cases of myoclonus or ataxia associated with COVID-19 ... either spontaneously or with immunotherapy.: Conclusions: This systematic review highlights myoclonus and ataxia ...
| Abstract | Background: Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic in December 2019, neurological manifestations have been recognized as potential complications. Relatively rare movement disorders associated with COVID-19 are increasingly reported in case reports or case series. Here, we present a case and systematic review of myoclonus and cerebellar ataxia associated with COVID-19. Methods: A systematic review was performed according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline using the PubMed and Ovid MEDLINE databases, from November 1, 2019 to December 6, 2020. Results: 51 cases of myoclonus or ataxia associated with COVID-19, including our case, were identified from 32 publications. The mean age was 59.6 years, ranging from 26 to 88 years, and 21.6% were female. Myoclonus was multifocal or generalized and had an acute onset, usually within 1 month of COVID-19 symptoms. Myoclonus occurred in isolation (46.7%), or with ataxia (40.0%) or cognitive changes (30.0%). Most cases improved within 2 months, and treatment included anti-epileptic medications or immunotherapy. Ataxia had an acute onset, usually within 1 month of COVID-19 symptoms, but could be an initial symptom. Concurrent neurological symptoms included cognitive changes (45.5%), myoclonus (36.4%), or a Miller Fisher syndrome variant (21.2%). Most cases improved within 2 months, either spontaneously or with immunotherapy. Conclusions: This systematic review highlights myoclonus and ataxia as rare and treatable post-infectious or para-infectious, immune-mediated phenomena associated with COVID-19. The natural history is unknown and future investigation is needed to further characterize these movement disorders and COVID-19. |
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| MeSH term(s) | Ataxia/complications ; COVID-19 ; Cerebellar Ataxia/complications ; Female ; Humans ; Middle Aged ; Myoclonus/etiology ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-02-22 | |||||
| Publishing country | Germany | |||||
| Document type | Case Reports ; Journal Article ; Review ; Systematic Review | |||||
| ZDB-ID | 187050-6 | |||||
| ISSN | 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X | |||||
| ISSN (online) | 1432-1459 | |||||
| ISSN | 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X | |||||
| DOI | 10.1007/s00415-021-10458-0 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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