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  1. Article ; Online: COVID-19 in Children with Asthma.

    Chatziparasidis, Grigorios / Kantar, Ahmad

    Lung

    2021  Volume 199, Issue 1, Page(s) 7–12

    Abstract: ... Furthermore, asthmatic children show less severe disease manifestations when infected with SARS-CoV-2 ... in asthmatic children. ... Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects both children and adults ...

    Abstract Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infects both children and adults but epidemiological and clinical data demonstrate that children are less likely to have a severe disease course or die. Furthermore, asthmatic children show less severe disease manifestations when infected with SARS-CoV-2 comparing to adults. This review focuses on SARS-CoV-2 and childhood asthma interaction and aims at summarizing the current knowledge of the potential mechanisms that ameliorate disease symptomatology in asthmatic children.
    MeSH term(s) Age Factors ; Asthma/epidemiology ; Asthma/immunology ; Asymptomatic Diseases ; COVID-19/immunology ; COVID-19/mortality ; COVID-19/virology ; Child ; Female ; Host-Pathogen Interactions ; Humans ; Male ; Prognosis ; Protective Factors ; Risk Factors ; SARS-CoV-2/immunology ; SARS-CoV-2/pathogenicity ; Severity of Illness Index
    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-021-00419-9
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  2. Article ; Online: Letter to the Editor: Regarding COVID-19 in Children with Asthma.

    Özdemir, Öner

    Lung

    2021  Volume 199, Issue 4, Page(s) 435–436

    MeSH term(s) Asthma ; COVID-19 ; Child ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-021-00459-1
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  3. Article ; Online: Authors' Response: COVID-19 in Children with Asthma.

    Chatziparasidis, Grigorios / Kantar, Ahmad

    Lung

    2021  Volume 199, Issue 4, Page(s) 437–438

    MeSH term(s) Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; COVID-19 ; Child ; Humans ; SARS-CoV-2
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2021-08-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 6165-7
    ISSN 1432-1750 ; 0341-2040
    ISSN (online) 1432-1750
    ISSN 0341-2040
    DOI 10.1007/s00408-021-00461-7
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  4. Article ; Online: The Indirect Impact of COVID-19 on Children With Asthma.

    Chavasse, Richard / Almario, Andres / Christopher, Anne / Kappos, Alexia / Shankar, Anu

    Archivos de bronconeumologia

    2020  Volume 56, Issue 11, Page(s) 768–769

    MeSH term(s) Adolescent ; Air Pollution/statistics & numerical data ; Asthma/epidemiology ; Betacoronavirus ; COVID-19 ; Child ; Child, Preschool ; Coronavirus Infections/epidemiology ; Emergencies/epidemiology ; Humans ; Infant ; Pandemics ; Pneumonia, Viral/epidemiology ; Quarantine/statistics & numerical data ; SARS-CoV-2 ; United Kingdom/epidemiology
    Keywords covid19
    Language Spanish
    Publishing date 2020-08-17
    Document type Letter
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2020.07.003
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  6. Article ; Online: The Indirect Impact of COVID-19 on Children With Asthma

    Chavasse, Richard / Almario, Andres / Christopher, Anne / Kappos, Alexia / Shankar, Anu

    Archivos de Bronconeumología (English Edition)

    2020  Volume 56, Issue 11, Page(s) 768–769

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 733126-5
    ISSN 1579-2129 ; 0300-2896
    ISSN (online) 1579-2129
    ISSN 0300-2896
    DOI 10.1016/j.arbr.2020.07.011
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  7. Article ; Online: The Indirect Impact of COVID-19 on Children With Asthma

    Chavasse, Richard / Almario, Andres / Christopher, Anne / Kappos, Alexia / Shankar, Anu

    Archivos de Bronconeumología

    2020  Volume 56, Issue 11, Page(s) 768–769

    Keywords Pulmonary and Respiratory Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 733126-5
    ISSN 0300-2896
    ISSN 0300-2896
    DOI 10.1016/j.arbres.2020.07.003
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  8. Article ; Online: COVID-19 and Asthma Onset in Children.

    Senter, James P / Aisenberg, Laura K / Dudley, Jesse W / Luan, Xianqun / Huang, Jing / Kenyon, Chén C / Hill, David A

    Pediatrics

    2024  Volume 153, Issue 5

    Abstract: ... significantly increased the hazard of new asthma diagnosis for children <5 years old.: Conclusions: SARS-CoV ... 2 PCR positivity was not associated with new asthma diagnosis in children within the observation ... children. Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can cause ...

    Abstract Background and objectives: Respiratory viral infections increase risk of asthma in infants and children. Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can cause severe lung inflammation and prolonged respiratory symptoms. We sought to determine whether SARS-CoV-2 infection modified pediatric incident asthma risk.
    Methods: This retrospective cohort study examined children ages 1 to 16 within the Children's Hospital of Philadelphia Care Network who received polymerase chain reaction (PCR) testing for SARS-CoV-2 between March 1, 2020 and February 28, 2021. Multivariable Cox regression models assessed the hazard ratio of new asthma diagnosis between SARS-CoV-2 PCR positive and SARS-CoV-2 PCR negative groups within an 18-month observation window. Models were adjusted for demographic characteristics, socioeconomic variables, and atopic comorbidities.
    Results: There were 27 423 subjects included in the study. In adjusted analyses, SARS-CoV-2 PCR positivity had no significant effect on the hazard of new asthma diagnosis (hazard ratio [HR]: 0.96; P = .79). Black race (HR: 1.49; P = .004), food allergies (HR: 1.26; P = .025), and allergic rhinitis (HR: 2.30; P < .001) significantly increased the hazard of new asthma diagnosis. Preterm birth (HR: 1.48; P = .005) and BMI (HR: 1.13; P < .001) significantly increased the hazard of new asthma diagnosis for children <5 years old.
    Conclusions: SARS-CoV-2 PCR positivity was not associated with new asthma diagnosis in children within the observation period, although known risk factors for pediatric asthma were confirmed. This study informs the prognosis and care of children with a history of SARS-CoV-2 infection.
    MeSH term(s) Humans ; Asthma/epidemiology ; Asthma/diagnosis ; COVID-19/diagnosis ; COVID-19/epidemiology ; Child ; Female ; Male ; Retrospective Studies ; Child, Preschool ; Adolescent ; Infant ; Risk Factors ; SARS-CoV-2 ; Rhinitis, Allergic/epidemiology ; Rhinitis, Allergic/diagnosis ; Proportional Hazards Models ; Philadelphia/epidemiology ; Food Hypersensitivity/epidemiology ; Food Hypersensitivity/diagnosis ; Food Hypersensitivity/complications ; Cohort Studies
    Language English
    Publishing date 2024-04-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 207677-9
    ISSN 1098-4275 ; 0031-4005
    ISSN (online) 1098-4275
    ISSN 0031-4005
    DOI 10.1542/peds.2023-064615
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  9. Article ; Online: Altered COVID-19 immunity in children with asthma by atopic status.

    Tong, Sherry / Scott, Jordan C / Eyoh, Enwono / Werthmann, Derek W / Stone, Addison E / Murrell, Amelie E / Sabino-Santos, Gilberto / Trinh, Ivy V / Chandra, Sruti / Elliott, Debra H / Smira, Ashley R / Velazquez, Jalene V / Schieffelin, John / Ning, Bo / Hu, Tony / Kolls, Jay K / Landry, Samuel J / Zwezdaryk, Kevin J / Robinson, James E /
    Gunn, Bronwyn M / Rabito, Felicia A / Norton, Elizabeth B

    The journal of allergy and clinical immunology. Global

    2024  Volume 3, Issue 2, Page(s) 100236

    Abstract: ... compromised in patients with asthma; however, whether this is true for SARS-CoV-2 immunity and children is ... unknown.: Objective: We aimed to evaluate SARS-CoV-2 immunity in children with asthma on the basis ... dust mite)-specific immunity.: Methods: Fifty-three children from an urban asthma study were ...

    Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a spectrum of clinical outcomes that may be complicated by severe asthma. Antiviral immunity is often compromised in patients with asthma; however, whether this is true for SARS-CoV-2 immunity and children is unknown.
    Objective: We aimed to evaluate SARS-CoV-2 immunity in children with asthma on the basis of infection or vaccination history and compared to respiratory syncytial viral or allergen (eg, cockroach, dust mite)-specific immunity.
    Methods: Fifty-three children from an urban asthma study were evaluated for medical history, lung function, and virus- or allergen-specific immunity using antibody or T-cell assays.
    Results: Polyclonal antibody responses to spike were observed in most children from infection and/or vaccination history. Children with atopic asthma or high allergen-specific IgE, particularly to dust mites, exhibited reduced seroconversion, antibody magnitude, and SARS-CoV-2 virus neutralization after SARS-CoV-2 infection or vaccination. T
    Conclusion: Mechanisms underpinning atopic and nonatopic asthma may complicate the development of memory to SARS-CoV-2 infection or vaccination and lead to a higher risk of repeated infection in these children.
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ISSN 2772-8293
    ISSN (online) 2772-8293
    DOI 10.1016/j.jacig.2024.100236
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  10. Article ; Online: Factors influencing asthma exacerbations in children following COVID-19 infection.

    Barrows, Jennifer / Morphew, Tricia / Ehwerhemuepha, Louis / Galant, Stanley Paul

    The journal of allergy and clinical immunology. In practice

    2023  Volume 12, Issue 1, Page(s) 229–231.e1

    MeSH term(s) Child ; Humans ; COVID-19 ; Asthma/epidemiology ; Asthma/drug therapy ; Anti-Asthmatic Agents/therapeutic use
    Chemical Substances Anti-Asthmatic Agents
    Language English
    Publishing date 2023-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2843237-X
    ISSN 2213-2201 ; 2213-2198
    ISSN (online) 2213-2201
    ISSN 2213-2198
    DOI 10.1016/j.jaip.2023.09.041
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