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  1. Article ; Online: Clinical characteristics and outcomes of COVID-19 in solid organ transplant recipients: A cohort study.

    Chaudhry, Zohra S / Williams, Jonathan D / Vahia, Amit / Fadel, Raef / Parraga Acosta, Tommy / Prashar, Rohini / Shrivastava, Pritika / Khoury, Nadeen / Pinto Corrales, Julio / Williams, Celeste / Nagai, Shunji / Abouljoud, Marwan / Samaniego-Picota, Milagros / Abreu-Lanfranco, Odaliz / Del Busto, Ramon / Ramesh, Mayur S / Patel, Anita / Alangaden, George J

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

    2020  Volume 20, Issue 11, Page(s) 3051–3060

    Abstract: Solid organ transplant recipients (SOTr) with coronavirus disease 2019 (COVID-19) are expected ... The clinical characteristics of 47 SOTr (38 kidneys and 9 nonkidney organs) were compared to 100 consecutive ... Multivariate analysis demonstrated that increasing age and clinical severity were associated with mortality. Transplant ...

    Abstract Solid organ transplant recipients (SOTr) with coronavirus disease 2019 (COVID-19) are expected to have poorer outcomes compared to nontransplant patients because of immunosuppression and comorbidities. The clinical characteristics of 47 SOTr (38 kidneys and 9 nonkidney organs) were compared to 100 consecutive hospitalized nontransplant controls. Twelve of 47 SOTr managed as outpatients were subsequently excluded from the outcome analyses to avoid potential selection bias. Chronic kidney disease (89% vs 57% P = .0007), diabetes (66% vs 33% P = .0007), and hypertension (94% vs 72% P = .006) were more common in the 35 hospitalized SOTr compared to controls. Diarrhea (54% vs 17%, P < .0001) was more frequent in SOTr. Primary composite outcome (escalation to intensive care unit, mechanical ventilation, or in-hospital all-cause mortality) was comparable between SOTr and controls (40% vs 48%, odds ratio [OR] 0.72 confidence interval [CI] [0.33-1.58] P = .42), despite more comorbidities in SOTr. Acute kidney injury requiring renal replacement therapy occurred in 20% of SOTr compared to 4% of controls (OR 6 CI [1.64-22] P = .007). Multivariate analysis demonstrated that increasing age and clinical severity were associated with mortality. Transplant status itself was not associated with mortality.
    MeSH term(s) Aged ; COVID-19/epidemiology ; Comorbidity ; Female ; Graft Rejection/epidemiology ; Graft Rejection/prevention & control ; Humans ; Immunosuppression Therapy/methods ; Incidence ; Intensive Care Units ; Male ; Middle Aged ; Organ Transplantation ; Pandemics ; Retrospective Studies ; Risk Factors ; SARS-CoV-2 ; Transplant Recipients ; United States/epidemiology
    Keywords covid19
    Language English
    Publishing date 2020-07-28
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2060594-8
    ISSN 1600-6143 ; 1600-6135
    ISSN (online) 1600-6143
    ISSN 1600-6135
    DOI 10.1111/ajt.16188
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  2. Article ; Online: Clinical characteristics and outcome of coronavirus disease 2019 infection in patients with solid organ transplants: A systematic review and meta-analysis.

    An, Wen / Wang, Qiuyang / Kim, Tae-Eun / Kang, Ju-Seop

    Journal of infection and public health

    2022  Volume 15, Issue 3, Page(s) 365–372

    Abstract: ... to investigate the clinical characteristics, morbidity, severity, and mortality of COVID-19 infection among solid ... in transplant recipients, most of them only involve a small number of patients and narrow geographic areas. This study aims ... rate of COVID-19 in SOT recipients was 2.10% [95% CI 1.35-3.01], and the proportion of severe infection ...

    Abstract Background: Although many studies have reported cases of COVID-19 infection in transplant recipients, most of them only involve a small number of patients and narrow geographic areas. This study aims to investigate the clinical characteristics, morbidity, severity, and mortality of COVID-19 infection among solid organ transplant (SOT) recipients by meta-analysis.
    Method: We performed a literature search using the databases PubMed, Web of Science, and Google Scholar as of November 26, 2020. We included randomized controlled trials and cohort studies, excluding case reports and small case series (n < 10). The pooled incidence proportion and 95% confidence intervals (CI) were used to estimate the combined results of forty-seven studies were included for the meta-analysis. Heterogeneity was assessed using I
    Results: The morbidity rate of COVID-19 in SOT recipients was 2.10% [95% CI 1.35-3.01], and the proportion of severe infection was 22.46% [95% CI 15.74-29.90]. The mortality rate was 17.38% [95% CI 13.72-21.34]. In the analysis by transplanted organ, the proportion of patients with severe infection was highest in recipients of two or more transplants 48.85% [95% CI 11.88-86.38]. The mortality rate was highest in lung transplant recipients 25.12% [95% CI 16.94-34.00]. The most common symptoms of COVID-19 in SOT recipients were fever (73.39%), cough (58.90%), and respiratory symptoms (45.77%).
    Conclusion: SOT was a risk factor for worse COVID-19 outcomes, although the morbidity of COVID-19 in SOT recipients was not markedly higher than the general population. These results may change when our understanding of the disease progress.
    MeSH term(s) COVID-19/complications ; COVID-19/epidemiology ; COVID-19/mortality ; Humans ; Morbidity ; Organ Transplantation ; Risk Factors ; SARS-CoV-2 ; Transplant Recipients
    Language English
    Publishing date 2022-02-19
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2467587-8
    ISSN 1876-035X ; 1876-0341
    ISSN (online) 1876-035X
    ISSN 1876-0341
    DOI 10.1016/j.jiph.2022.02.002
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  3. Article ; Online: Clinical characteristics and outcome of coronavirus disease 2019 infection in patients with solid organ transplants

    Wen An / Qiuyang Wang / Tae-Eun Kim / Ju-Seop Kang

    Journal of Infection and Public Health, Vol 15, Iss 3, Pp 365-

    A systematic review and meta-analysis

    2022  Volume 372

    Abstract: ... to investigate the clinical characteristics, morbidity, severity, and mortality of COVID-19 infection among solid ... in transplant recipients, most of them only involve a small number of patients and narrow geographic areas. This study aims ... s test. Results: The morbidity rate of COVID-19 in SOT recipients was 2.10% [95% CI 1.35–3.01], and ...

    Abstract Background: Although many studies have reported cases of COVID-19 infection in transplant recipients, most of them only involve a small number of patients and narrow geographic areas. This study aims to investigate the clinical characteristics, morbidity, severity, and mortality of COVID-19 infection among solid organ transplant (SOT) recipients by meta-analysis. Method: We performed a literature search using the databases PubMed, Web of Science, and Google Scholar as of November 26, 2020. We included randomized controlled trials and cohort studies, excluding case reports and small case series (n < 10). The pooled incidence proportion and 95% confidence intervals (CI) were used to estimate the combined results of forty-seven studies were included for the meta-analysis. Heterogeneity was assessed using I2. Freeman-Tukey double arcsine transformation was used to stabilize the specific rate variance. Publication bias was using Egger’s test. Results: The morbidity rate of COVID-19 in SOT recipients was 2.10% [95% CI 1.35–3.01], and the proportion of severe infection was 22.46% [95% CI 15.74–29.90]. The mortality rate was 17.38% [95% CI 13.72–21.34]. In the analysis by transplanted organ, the proportion of patients with severe infection was highest in recipients of two or more transplants 48.85% [95% CI 11.88–86.38]. The mortality rate was highest in lung transplant recipients 25.12% [95% CI 16.94–34.00]. The most common symptoms of COVID-19 in SOT recipients were fever (73.39%), cough (58.90%), and respiratory symptoms (45.77%). Conclusion: SOT was a risk factor for worse COVID-19 outcomes, although the morbidity of COVID-19 in SOT recipients was not markedly higher than the general population. These results may change when our understanding of the disease progress.
    Keywords COVID-19 ; Solid organ transplantation ; Meta-analysis ; SOT ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
    Subject code 310 ; 610
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Clinical characteristics and outcome of immunocompromised patients with COVID-19 caused by the Omicron variant: a prospective observational study

    Malahe, S. Reshwan K. / Hoek, Rogier A.S. / Dalm, Virgil A.S.H. / Broers, Annoek E.C. / den Hoed, Caroline M. / Manintveld, Olivier C. / Baan, Carla C. / van Deuzen, Charlotte M. / Papageorgiou, Grigorios / Bax, Hannelore I. / van Kampen, Jeroen J. / Hellemons, Merel E. / Kho, Marcia M.L. / de Vries, Rory D. / Molenkamp, Richard / Reinders, Marlies E.J. / Rijnders, Bart J.A.

    medRxiv

    Abstract: ... of immunocompromised patients with COVID-19 caused by Omicron. Methods Solid organ transplant recipients, patients on anti-CD20 ... performed. Findings A total of 114 consecutive immunocompromised patients(88% after a solid organ transplant ... in immunocompromised patients are lacking. We investigated the clinical characteristics and outcome of a cohort ...

    Abstract Summary Background In the general population, illness after infection with the SARS-CoV-2 Omicron variant is less severe compared with previous variants. Data on the disease burden of Omicron in immunocompromised patients are lacking. We investigated the clinical characteristics and outcome of a cohort of immunocompromised patients with COVID-19 caused by Omicron. Methods Solid organ transplant recipients, patients on anti-CD20 therapy, and allogenic hematopoietic stem cell transplantation recipients on immunosuppressive therapy infected with the Omicron variant, were included. Patients were contacted regularly until symptom resolution. Clinical characteristics of consenting patients were collected through their electronic patient files. To identify possible risk factors for hospitalization, a univariate logistic analysis was performed. Findings A total of 114 consecutive immunocompromised patients(88% after a solid organ transplant) were enrolled. Eighty-nine percent had previously received three mRNA vaccinations. While only one patient died, 23(20%) required hospital admission for a median of 11 days. A low SARS-CoV-2 IgG antibody response(<300 BAU/mL) at diagnosis, higher age, being a lung transplant recipient, more comorbidities and a higher frailty were associated with hospital admission(all p<0.01). At the end of follow-up, 25% had still not fully recovered. Of the 23 hospitalized patients, 70% had a negative and 92% a low IgG (<300 BAU/mL) antibody response at admission. Sotrovimab was administered to 17 of them, of which one died. Interpretation While the mortality in immunocompromised patients infected with Omicron was low, hospital admission was frequent and the duration of symptoms often prolonged. Besides vaccination, other interventions are needed to limit the morbidity from COVID-19 in immunocompromised patients. Funding None.
    Keywords covid19
    Language English
    Publishing date 2022-04-27
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2022.04.25.22273197
    Database COVID19

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  5. Article ; Online: Clinical characteristics and outcomes of COVID‐19 in solid organ transplant recipients

    Chaudhry, Zohra S. / Williams, Jonathan D. / Vahia, Amit / Fadel, Raef / Parraga Acosta, Tommy / Prashar, Rohini / Shrivastava, Pritika / Khoury, Nadeen / Pinto Corrales, Julio / Williams, Celeste / Nagai, Shunji / Abouljoud, Marwan / Samaniego‐Picota, Milagros / Abreu‐Lanfranco, Odaliz / Busto, Ramon / Ramesh, Mayur S. / Patel, Anita / Alangaden, George J.

    American Journal of Transplantation ; ISSN 1600-6135 1600-6143

    A cohort study

    2020  

    Keywords Immunology and Allergy ; Pharmacology (medical) ; Transplantation ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    DOI 10.1111/ajt.16188
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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