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Article: Acute kidney damage in COVID-19 patients.

Chebotareva, Natalia / Berns, Svetlana / Androsova, Tatyana / Moiseev, Sergey

2021 Volume 95, Issue 5, Page(s) 227–239

Abstract: The presentation of kidney damage in Coronavirus disease 2019 (COVID-19) varies significantly ... According to recent studies, the development of acute kidney injury (AKI) in severe cases of COVID-19 ... with severe respiratory failure. It is known that AKI is a risk factor for mortality in COVID-19 patients. ...

Abstract	The presentation of kidney damage in Coronavirus disease 2019 (COVID-19) varies significantly. According to recent studies, the development of acute kidney injury (AKI) in severe cases of COVID-19 infection significantly worsens the prognosis of these patients. The pathological changes in kidneys might be caused directly by the cytopathic effect mediated by local replication of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or indirectly because of systemic immune response or hypercoagulation, so-called immunothrombosis. Other causes, such as hypovolemia and hypoxia, may also contribute to AKI. Acute kidney disease often develops in elderly patients with underlying comorbidities or in critically ill patients with severe respiratory failure. It is known that AKI is a risk factor for mortality in COVID-19 patients.
MeSH term(s)	Acute Kidney Injury/pathology ; Acute Kidney Injury/virology ; COVID-19/complications ; COVID-19/physiopathology ; Critical Illness ; Humans ; Prognosis ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2021-04-27
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	185101-9
ISSN	0301-0430
ISSN	0301-0430
DOI	10.5414/CN110357
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Article ; Online: Acute Kidney Injury and Kidney Damage in COVID-19 Patients.

Na, Ki Ryang / Kim, Hae Ri / Ham, Youngrok / Choi, Dae Eun / Lee, Kang Wook / Moon, Jae Young / Kim, Yeon Sook / Cheon, Shinhye / Sohn, Kyung Mok / Kim, Jungok / Kim, Sungmin / Jeong, Hyeongseok / Jeon, Jae Wan

Journal of Korean medical science

2020 Volume 35, Issue 28, Page(s) e257

Abstract: ... to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19.: Methods ... From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital ... COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This disease, which is quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a high mortality rate. This study aimed to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19. Methods: From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital were analyzed; all patients underwent routine urinalysis and were tested for serum creatinine, urine protein to creatinine ratio (PCR), and urine albumin to creatinine ratio (ACR). Results: Acute kidney injury (AKI) occurred in 3 (4.5%) of the 66 patients, and 1 patient with AKI stage 3 underwent hemodialysis. Upon follow-up, all 3 patients recovered normal renal function. Compared with patients with mild COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were markedly increased. Conclusion: The incidence of AKI was not high in COVID-19 patients. The lower mortality rate in SARS-CoV-2 infection compared with previous Middle East respiratory syndrome and SARS-CoV infections is thought to be associated with a low incidence of dysfunction in organs other than the lungs.
MeSH term(s)	Acute Kidney Injury/epidemiology ; Acute Kidney Injury/pathology ; Acute Kidney Injury/virology ; Aged ; Albumins/analysis ; Albuminuria/urine ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/pathology ; Creatinine/blood ; Female ; Glomerular Filtration Rate/physiology ; Humans ; Kidney Function Tests ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/pathology ; Proteinuria/urine ; Republic of Korea/epidemiology ; SARS-CoV-2
Chemical Substances	Albumins ; Creatinine (AYI8EX34EU)
Keywords	covid19
Language	English
Publishing date	2020-07-20
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	639262-3
ISSN	1598-6357 ; 1011-8934
ISSN (online)	1598-6357
ISSN	1011-8934
DOI	10.3346/jkms.2020.35.e257
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Article: Acute Kidney Injury and Kidney Damage in COVID-19 Patients

J Korean Med Sci

Abstract: ... to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19. METHODS ... From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital ... COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were ...

Abstract	BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This disease, which is quickly spreading worldwide, has high potential for infection and causes rapid progression of lung lesions, resulting in a high mortality rate. This study aimed to investigate the effects of SARS-CoV-2 infection on renal function in patients with COVID-19. METHODS: From February 21 to April 24, 2020, 66 patients diagnosed with COVID-19 at Chungnam National University Hospital were analyzed; all patients underwent routine urinalysis and were tested for serum creatinine, urine protein to creatinine ratio (PCR), and urine albumin to creatinine ratio (ACR). RESULTS: Acute kidney injury (AKI) occurred in 3 (4.5%) of the 66 patients, and 1 patient with AKI stage 3 underwent hemodialysis. Upon follow-up, all 3 patients recovered normal renal function. Compared with patients with mild COVID-19, AKI (n = 3) occurred in patients with severe COVID-19, of whom both urine PCR and ACR were markedly increased. CONCLUSION: The incidence of AKI was not high in COVID-19 patients. The lower mortality rate in SARS-CoV-2 infection compared with previous Middle East respiratory syndrome and SARS-CoV infections is thought to be associated with a low incidence of dysfunction in organs other than the lungs.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #655156
Database	COVID19

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Article ; Online: Altered kidney function induced by SARS-CoV-2 infection and acute kidney damage markers predict survival outcomes of COVID-19 patients: a prospective pilot study.

Temiz, Mustafa Zafer / Hacibey, Ibrahim / Yazar, Ramazan Omer / Sevdi, Mehmet Salih / Kucuk, Suat Hayri / Alkurt, Gizem / Doganay, Levent / Dinler Doganay, Gizem / Dincer, Muhammet Murat / Yuruk, Emrah / Erkalp, Kerem / Muslumanoglu, Ahmet Yaser

Renal failure

2022 Volume 44, Issue 1, Page(s) 233–240

Abstract: ... of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19 ... demonstrated the acute kidney injury related to COVID-19. Moreover, urine KIM-1/creatinine ratio was associated ... Methods: Forty-seven participants was included and grouped as: 'COVID-19 patients before treatment' ...

Abstract	Background: Literature with regard to coronavirus disease 2019 (COVID-19) associated morbidities and the risk factors for death are still emerging. In this study, we investigated the presence of kidney damage markers and their predictive value for survival among hospitalized subjects with COVID-19. Methods: Forty-seven participants was included and grouped as: 'COVID-19 patients before treatment', 'COVID-19 patients after treatment', 'COVID-19 patients under treatment in intensive care unit (ICU)', and 'controls'. Kidney function tests and several kidney injury biomarkers were compared between the groups. Cumulative rates of death from COVID-19 were determined using the Kaplan-Meier method. The associations between covariates including kidney injury markers and death from COVID-19 were examined, as well. Results: Serum creatinine and cystatin C levels, urine Kidney Injury Molecule-1 (KIM-1)/creatinine ratio, and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), CKD-EPI cystatin C, and CKD-EPI creatinine-cystatin C levels demonstrated significant difference among the groups. The most significant difference was noted between the groups 'COVID-19 patients before treatment' and 'COVID-19 patients under treatment in ICU'. Advancing age, proteinuria, elevated serum cystatin C, and urine KIM-1/creatinine ratio were all significant univariate correlates of death ( Conclusions: Our findings clearly demonstrated the acute kidney injury related to COVID-19. Moreover, urine KIM-1/creatinine ratio was associated with COVID-19 specific death.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/etiology ; Adult ; Aged ; Aged, 80 and over ; Biomarkers/analysis ; COVID-19/complications ; COVID-19/mortality ; COVID-19/therapy ; Creatinine/urine ; Cystatin C/blood ; Female ; Hepatitis A Virus Cellular Receptor 1/metabolism ; Humans ; Male ; Middle Aged ; Pilot Projects ; Prospective Studies ; Proteinuria/diagnosis ; Proteinuria/etiology ; Risk Factors ; SARS-CoV-2/metabolism ; Survival Analysis ; Urinalysis
Chemical Substances	Biomarkers ; Cystatin C ; Hepatitis A Virus Cellular Receptor 1 ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2022-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2022.2032743
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Article: Outcomes of Hospitalized Patients With COVID-19 With Acute Kidney Injury and Acute Cardiac Injury.

Lu, Justin Y / Buczek, Alexandra / Fleysher, Roman / Hoogenboom, Wouter S / Hou, Wei / Rodriguez, Carlos J / Fisher, Molly C / Duong, Tim Q

Frontiers in cardiovascular medicine

2022 Volume 8, Page(s) 798897

Abstract: ... in COVID-19 patients who developed both acute kidney injury (AKI) and acute cardiac injury (ACI), and ... consisted of hospitalized COVID-19 patients at Montefiore Health System in Bronx, New York between March 11 ... COVID-19 patients, 44, 19, 9, and 28% had NI, AKI, ACI, and AKI-ACI, respectively. Most ACI presented ...

Abstract	Purpose: This study investigated the incidence, disease course, risk factors, and mortality in COVID-19 patients who developed both acute kidney injury (AKI) and acute cardiac injury (ACI), and compared to those with AKI only, ACI only, and no injury (NI). Methods: This retrospective study consisted of hospitalized COVID-19 patients at Montefiore Health System in Bronx, New York between March 11, 2020 and January 29, 2021. Demographics, comorbidities, vitals, and laboratory tests were collected during hospitalization. Predictive models were used to predict AKI, ACI, and AKI-ACI onset. Longitudinal laboratory tests were analyzed with time-lock to discharge alive or death. Results: Of the 5,896 hospitalized COVID-19 patients, 44, 19, 9, and 28% had NI, AKI, ACI, and AKI-ACI, respectively. Most ACI presented very early (within a day or two) during hospitalization in contrast to AKI ( Conclusions: COVID-19 patients with AKI-ACI had markedly worse outcomes compared to those only AKI, ACI and NI. Common laboratory variables accurately predicted AKI-ACI. The ability to identify patients at risk for AKI-ACI could lead to earlier intervention and improvement in clinical outcomes.
Language	English
Publishing date	2022-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2021.798897
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Article ; Online: Kidney injury molecule-1: potential biomarker of acute kidney injury and disease severity in patients with COVID-19.

Vogel, Manuel J / Mustroph, Julian / Staudner, Stephan T / Leininger, Simon B / Hubauer, Ute / Wallner, Stefan / Meindl, Christine / Hanses, Frank / Zimmermann, Markus / Maier, Lars S / Jungbauer, Carsten G / Hupf, Julian

Journal of nephrology

2021 Volume 34, Issue 4, Page(s) 1007–1018

Abstract: ... from acute kidney injury during their stay. Nine COVID-19 patients and two non-COVID-19 patients were admitted to the ICU ... disease in patients with COVID-19.: Methods and results: In this prospective observational ... Eight patients from the COVID-19 cohort and five of the non-COVID-19-patients suffered ...

Abstract	Aims: The aim of the current study was to evaluate whether tubular markers kidney injury molecule-1 (KIM-1) and N-acetyl-ß-glucosaminidase (NAG) are related to acute kidney injury (AKI) and severe disease in patients with COVID-19. Methods and results: In this prospective observational clinical trial we examined a cohort of 80 patients with proof of acute respiratory infection and divided them into a COVID-19 cohort (n = 54) and a control cohort (n = 26). KIM-1 and NAG were measured from urine samples collected in the emergency department. We assessed the development of AKI, admission to the intensive care unit (ICU) and intrahospital death as clinical endpoints. Urinary KIM-1 and NAG were not significantly different between patients with SARS-CoV-2 and those with other respiratory infections (each p = n.s.). Eight patients from the COVID-19 cohort and five of the non-COVID-19-patients suffered from acute kidney injury during their stay. Nine COVID-19 patients and two non-COVID-19 patients were admitted to the ICU. KIM-1 was significantly elevated in COVID-19 patients with, compared to those without AKI (p = 0.005), as opposed to NAG and creatinine (each p = n.s.). Furthermore, KIM-1 was significantly elevated in the patients with COVID-19 that had to be transferred to the ICU (p = 0.015), in contrast to NAG and creatinine (each p = n.s.). Conclusion: Assessing KIM-1 in patients with COVID-19 might provide additional value in recognizing AKI at an early stage of disease. Further, KIM-1 might indicate higher risk for clinical deterioration as displayed by admission to the ICU.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Biomarkers ; COVID-19 ; Hepatitis A Virus Cellular Receptor 1 ; Humans ; Kidney ; SARS-CoV-2 ; Severity of Illness Index
Chemical Substances	Biomarkers ; Hepatitis A Virus Cellular Receptor 1
Language	English
Publishing date	2021-06-10
Publishing country	Italy
Document type	Journal Article ; Observational Study
ZDB-ID	1093991-x
ISSN	1724-6059 ; 1120-3625 ; 1121-8428
ISSN (online)	1724-6059
ISSN	1120-3625 ; 1121-8428
DOI	10.1007/s40620-021-01079-x
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Article ; Online: Altered kidney function and acute kidney damage markers predict survival outcomes of COVID-19 patients: A prospective pilot study.

Temiz, Mustafa Zafer / Hacibey, Ibrahim / Yazar, Ramazan Omer / Sevdi, Mehmet Salih / Kucuk, Suat Hayri / Alkurt, Gizem / Doganay, Levent / Dinler-Doganay, Gizem / Dincer, Muhammed Murat / Yuruk, Emrah / Erkalp, Kerem / Muslumanoglu, Ahmet Yaser

medRxiv

Abstract: ... The causes of the difference were more altered kidney function and increased acute kidney damage in COVID-19 ... the acute kidney damage by COVID-19 using molecular kidney damage markers for the first time ... In this regard, considering kidney function and kidney damage markers must not be ignored in the COVID-19 ...

Abstract	Background: The central role in the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), called as coronavirus disease 2019 (COVID-19), infection is attributed to angiotensin-converting enzyme 2 (ACE-2). ACE-2 expressing respiratory system involvement is the main clinical manifestation of the infection. However, literature about the association between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and higher ACE-2 expressing kidney is very limited. In this study, we primarily aimed to investigate whether there is a kidney injury during the course of SARS-CoV-2 infection. The predictive value of kidney injury for survival was also determined. Methods: A total of 47 participants who met the inclusion criteria were included in the study. The participants were classified as COVID-19 patients before treatment, COVID-19 patients after treatment, COVID-19 patients under treatment in ICU and controls. The parameters comorbidity, serum creatinine and cystatin C levels, CKD-EPI eGFR levels, KIM-1 and NGAL levels, urine KIM-1/creatinine and NGAL/creatinine ratios were statistically compared between the groups. The associations between covariates including kidney disease indicators and death from COVID-19 were examined using Cox proportional hazard regression analysis. Results: Serum creatinine and cystatin C levels, urine KIM-1/creatinine levels, and CKD-EPI, CKD-EPI cystatin C and CKD-EPI creatinine-cystatin C eGFR levels exhibited significant difference in the groups. The causes of the difference were more altered kidney function and increased acute kidney damage in COVID-19 patients before treatment and under treatment in ICU. Additionally, incidences of comorbidity and proteinuria in the urine analysis were higher in the COVID-19 patients under treatment in ICU group. Urine KIM-1/creatinine ratio and proteinuria were associated with COVID-19 specific death. Conclusions: We found that COVID-19 patients under treatment in ICU exhibited extremely higher levels of serum cystatin C, and urine KIM-1/creatinine and urine NGAL/creatinine ratios. These results clearly described the acute kidney damage by COVID-19 using molecular kidney damage markers for the first time in the literature. Lowered CKD-EPI, CKD-EPI cystatin C and CKD-EPI creatinine-cystatin C eGFR levels were determined in them, as well. Urine KIM-1/creatinine ratio and proteinuria were associated with COVID-19 specific death. In this regard, considering kidney function and kidney damage markers must not be ignored in the COVID-19 patients, and serial monitoring of them should be considered.
Keywords	covid19
Language	English
Publishing date	2021-01-12
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2021.01.10.20249079
Database	COVID19

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Article ; Online: Acute cardiac injury and acute kidney injury associated with severity and mortality in patients with COVID-19.

Li, W-X / Xu, W / Huang, C-L / Fei, L / Xie, X-D / Li, Q / Chen, L

European review for medical and pharmacological sciences

2021 Volume 25, Issue 4, Page(s) 2114–2122

Abstract: ... acute kidney injury (AKI), and then investigate their effect on severity and mortality in patients with COVID-19 ... Patients and methods: A total of 1249 patients with COVID-19 were included in this retrospective study ... AKI were not common in COVID-19 patients in Shanghai, China. However, patients with ACI/AKI had higher ...

Abstract	Objective: To determine the incidence and risk factors for acute cardiac injury (ACI) and acute kidney injury (AKI), and then investigate their effect on severity and mortality in patients with COVID-19. Patients and methods: A total of 1249 patients with COVID-19 were included in this retrospective study. Predictors of ACI and AKI were investigated. Multivariable-logistic regression models were used to determine the association of ACI (or AKI) with severity and mortality. Results: Median age of patients was 36 years and 61.9% were male. ACI and AKI were observed in 53 (4.2%) and 91 (7.3%) of patients, respectively. Patients with age > 60 years, chronic heart disease, decreased lymphocyte and increased CRP, PCT, and ESR on hospital admission, and Lopinavir/Ritonavir use showed higher odds of ACI. Patients with age > 60 years, male, obesity, hypertension, chronic kidney disease, decreased lymphocyte and increased CRP, PCT, and ESR on hospital admission showed higher odds of AKI. Increased Hs-cTnI (> 300 ng/L), Pro-BNP (> 2500 pg/ml) and decreased e-GFR (< 60 ml/min) revealed higher adjusted mortality. Conclusions: ACI and AKI were not common in COVID-19 patients in Shanghai, China. However, patients with ACI/AKI had higher severity-rate and mortality-rate when compared to those without ACI/AKI.
MeSH term(s)	Acute Kidney Injury/complications ; Acute Kidney Injury/mortality ; Aged ; COVID-19/complications ; COVID-19/mortality ; China/epidemiology ; Female ; Heart Diseases/complications ; Heart Diseases/mortality ; Hospitalization/statistics & numerical data ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index
Language	English
Publishing date	2021-03-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202102_25117
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Article ; Online: Remdesivir use and risks of acute kidney injury and acute liver injury among patients hospitalised with COVID-19: a self-controlled case series study.

Wong, Carlos K H / Au, Ivan C H / Cheng, Wing Yiu / Man, Kenneth K C / Lau, Kristy T K / Mak, Lung Yi / Lui, Sing Leung / Chung, Matthew S H / Xiong, Xi / Lau, Eric H Y / Cowling, Benjamin J

Alimentary pharmacology & therapeutics

2022 Volume 56, Issue 1, Page(s) 121–130

Abstract: ... using the conditional Poisson regression models.: Results: Of 860 COVID-19 patients administered ... COVID-19 cases in Hong Kong. Outcomes of AKI and ALI were defined using the KDIGO Guideline and Asia ... The increased risks of AKI and ALI associated with intravenous remdesivir treatment for COVID-19 may be due ...

Abstract	Background and aim: To investigate and quantify the risks of AKI and ALI associated with remdesivir use, given the underlying diseases of SARS-CoV-2 infection. Methods: This self-controlled case series (SCCS) study was conducted using electronic hospital records between 23 January 2020 and 31 January 2021 as retrieved from the Hong Kong Hospital Authority which manages all laboratory-confirmed COVID-19 cases in Hong Kong. Outcomes of AKI and ALI were defined using the KDIGO Guideline and Asia Pacific Association of Study of Liver consensus guidelines. Incidence rate ratios (IRR) for AKI and ALI following the administration of remdesivir (exposure) in comparison to a non-exposure period were estimated using the conditional Poisson regression models. Results: Of 860 COVID-19 patients administered remdesivir during hospitalisation, 334 (38.8%) and 137 (15.9%) had incident ALI and AKI, respectively. Compared with the baseline period, both ALI and AKI risks were increased significantly during the pre-exposure period (ALI: IRR = 6.169, 95% CI = 4.549-8.365; AKI: IRR = 7.074, 95% CI = 3.763-13.298) and remained elevated during remdesivir treatment. Compared to the pre-exposure period, risks of ALI and AKI were not significantly higher in the first 2 days of remdesivir initiation (ALI: IRR = 1.261, 95% CI = 0.915-1.737; AKI: IRR = 1.261, 95% CI = 0.889-1.789) and between days 2 and 5 of remdesivir treatment (ALI: IRR = 1.087, 95% CI = 0.793-1.489; AKI: IRR = 1.152, 95% CI = 0.821-1.616). Conclusion: The increased risks of AKI and ALI associated with intravenous remdesivir treatment for COVID-19 may be due to the underlying SARS-CoV-2 infection. The risks of AKI and ALI were elevated in the pre-exposure period, yet no such increased risks were observed following remdesivir initiation when compared to the pre-exposure period.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute Kidney Injury/epidemiology ; Adenosine Monophosphate/analogs & derivatives ; Alanine/analogs & derivatives ; COVID-19/drug therapy ; Hong Kong ; Humans ; Liver ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
Chemical Substances	remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; Alanine (OF5P57N2ZX)
Language	English
Publishing date	2022-03-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639012-2
ISSN	1365-2036 ; 0269-2813 ; 0953-0673
ISSN (online)	1365-2036
ISSN	0269-2813 ; 0953-0673
DOI	10.1111/apt.16894
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Article ; Online: Acute kidney injury in COVID-19: are kidneys the target or just collateral damage? A comprehensive assessment of viral RNA and AKI rate in patients with COVID-19.

Enikeev, Dmitry / Taratkin, Mark / Efetov, Sergey / Shlomina, Alexandra / Boldyreva, Margarita / Galkina, Irina / Spivak, Leonid / Gitel, Evgeniy / Kuchieva, Agunda / Mikhailov, Vasiliy / Teoh, Jeremy Yuen-Chun / Herrmann, Thomas R W / Kikic, Željko / Fomin, Viktor / Shariat, Shahrokh F / Glybochko, Petr

Current opinion in urology

2021 Volume 31, Issue 4, Page(s) 363–368

Abstract: ... patients with COronaVIrus Disease 2019 (COVID-19) it was found that frequency of AKI of 9.6% (32 cases ... for patients with COVID-19 and is normally correlated with the severity of the disease and the patient's ... any traces of messenger ribonucleic acid (mRNA) in our group. Both COVID-19 severity (odds ratio, OR = 23.09 ...

Abstract	Purpose of review: To investigate the possible effects of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) on kidney function and assess the rate of viral ribonucleic acid (RNA) shedding/detection in urine. Recent findings: Most of the research on the topic suggests that for the moment our ability to estimate whether SARS-CoV-2 is a direct causative agent in acute kidney injury (AKI) or whether it has a cytokine storm effect is limited. During our prospective assessment of 333 patients with COronaVIrus Disease 2019 (COVID-19) it was found that frequency of AKI of 9.6% (32 cases). Despite previous data suggestive of the ability to detect SARS-CoV-2 in urine, we were unable to identify any traces of messenger ribonucleic acid (mRNA) in our group. Both COVID-19 severity (odds ratio, OR = 23.09, confidence interval, CI 7.89-67.57, P < 0.001) and chronic kidney disease (CKD) history (OR = 7.17, CI 2.09-24.47, P = 0.002) were associated with the AKI rate. Summary: AKI is a relatively frequent condition for patients with COVID-19 and is normally correlated with the severity of the disease and the patient's history of CKD. The available data fail to address whether SARS-CoV-2 mRNA is present in urine, whereas our prospective trial data suggest that mRNA is undetectable in urine irrespective of the severity of the disease.
MeSH term(s)	Acute Kidney Injury/diagnosis ; Acute Kidney Injury/epidemiology ; COVID-19 ; Humans ; Kidney ; Prospective Studies ; RNA, Viral/genetics ; SARS-CoV-2
Chemical Substances	RNA, Viral
Language	English
Publishing date	2021-05-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1091792-5
ISSN	1473-6586 ; 0963-0643
ISSN (online)	1473-6586
ISSN	0963-0643
DOI	10.1097/MOU.0000000000000901
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Inter-library loan at ZB MED

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In stock of ZB MED Cologne/Königswinter

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In stock of ZB MED Cologne/Königswinter

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Full text online

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Inter-library loan at ZB MED

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In stock of ZB MED Cologne/Königswinter

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Full text online

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In stock of ZB MED Cologne/Königswinter

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More links

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In stock of ZB MED Cologne/Königswinter

Order via subito