Article ; Online: Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production.
Signal transduction and targeted therapy
2020 Volume 5, Issue 1, Page(s) 121
| MeSH term(s) | Adenoma/ethnology ; Adenoma/genetics ; Adenoma/pathology ; Angiotensin-Converting Enzyme 2 ; Asian Continental Ancestry Group ; Basigin/genetics ; Basigin/metabolism ; Betacoronavirus/genetics ; Betacoronavirus/metabolism ; Betacoronavirus/pathogenicity ; COVID-19 ; Cathepsin B/genetics ; Cathepsin B/metabolism ; Cathepsin L/genetics ; Cathepsin L/metabolism ; Colon/metabolism ; Colon/pathology ; Colon/virology ; Colorectal Neoplasms/ethnology ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; Coronavirus Infections/ethnology ; Coronavirus Infections/genetics ; Coronavirus Infections/pathology ; Coronavirus Infections/virology ; Epithelial Cells/metabolism ; Epithelial Cells/pathology ; Epithelial Cells/virology ; Furin/genetics ; Furin/metabolism ; Host-Pathogen Interactions/genetics ; Humans ; Interleukin-6/blood ; Interleukin-6/genetics ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/ethnology ; Pneumonia, Viral/genetics ; Pneumonia, Viral/pathology ; Pneumonia, Viral/virology ; Receptors, Virus/genetics ; Receptors, Virus/metabolism ; SARS-CoV-2 ; Serine Endopeptidases/genetics ; Serine Endopeptidases/metabolism ; Severity of Illness Index ; Single-Cell Analysis ; Transcriptome ; Tumor Necrosis Factor-alpha/blood ; Tumor Necrosis Factor-alpha/genetics ; Virus Internalization |
|---|---|
| Chemical Substances | BSG protein, human ; IL6 protein, human ; Interleukin-6 ; Receptors, Virus ; Tumor Necrosis Factor-alpha ; Basigin (136894-56-9) ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-) ; FURIN protein, human (EC 3.4.21.75) ; Furin (EC 3.4.21.75) ; CTSB protein, human (EC 3.4.22.1) ; Cathepsin B (EC 3.4.22.1) ; CTSL protein, human (EC 3.4.22.15) ; Cathepsin L (EC 3.4.22.15) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-08 |
| Publishing country | England |
| Document type | Letter ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2886872-9 |
| ISSN | 2059-3635 ; 2095-9907 |
| ISSN (online) | 2059-3635 |
| ISSN | 2095-9907 |
| DOI | 10.1038/s41392-020-00237-0 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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