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  1. Article ; Online: Traditional Chinese medicine for the prevention and treatment of COVID-19: A protocol for systematic review and network meta-analysis.

    Wang, Xin / Wang, Yafeng / Lu, Hairu / Yan, Luqing

    Medicine

    2022  Volume 100, Issue 52, Page(s) e28375

    Abstract: ... Reporting Items for Systematic Reviews and Meta-analysis Protocols. We will search Chinese electronic ... Conclusion: This systematic review and network meta-analysis will use both direct and indirect evidence ... to compare the differences of all Traditional Chinese medicine treatment for COVID-19 patients, providing ...

    Abstract Background: The coronavirus disease 2019 (COVID-19) pandemic spread to most of the world's countries during its first and subsequent waves, often increasing in an almost exponential trend. Traditional Chinese medicine has played a vital role in this epidemic. Nonetheless, size of effect, certainty of the evidence, optimal therapy regimen, and selection of patients who are likely to benefit most are factors that remain to be evaluated. This study aims to assess and rank where appropriate the relative effects of interventions for the prevention and treatment of COVID-19.
    Method: This study will follow the Preferred Reporting Items for Systematic Reviews and Meta-analysis Protocols. We will search Chinese electronic database (CBM, Wanfang and CNKI) and international electronic databases (PubMed, Embase, Cochrane Library, and Web of Science) for identify all relevant published studies. Study selection, data collection and assessment of study bias will be conducted independently by a pair of independent reviewers. The Cochrane risk of bias tool will be used for the risk of bias assessment. We will use the advance of GRADE to rate the certainty of network meta-analysis. Data analysis will be performed with R-3.6.1 and WinBUGS software.
    Results: The results of this study will be published in a peer-reviewed journal.
    Conclusion: This systematic review and network meta-analysis will use both direct and indirect evidence to compare the differences of all Traditional Chinese medicine treatment for COVID-19 patients, providing decision-makers and clinical practitioners with a complete, high-quality and up-to-date synthesis of evidence.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/prevention & control ; Humans ; Medicine, Chinese Traditional ; Meta-Analysis as Topic ; Network Meta-Analysis ; Pandemics ; Research Design ; SARS-CoV-2 ; Systematic Reviews as Topic
    Language English
    Publishing date 2022-01-01
    Publishing country United States
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000028375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Chinese medicine for COVID-19: A protocol for systematic review and meta-analysis.

    Chen, Huizhen / Xie, Ziyan / Zhu, Yuxia / Chen, Qiu / Xie, Chunguang

    Medicine

    2020  Volume 99, Issue 25, Page(s) e20660

    Abstract: ... of COVID-19 with traditional Chinese medicine will be summarized, and evaluation of the efficacy and ... of respiratory diseases in China. The aim of this study is to assess the efficacy and safety of Chinese medicine for COVID ... if they recruited participants with COVID-19 for assessing the effect of Chinese medicine vs control (placebo, no ...

    Abstract Background: Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first identified during an investigation into an outbreak in Wuhan, China. The clinical spectrum of SARS-CoV-2 infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia with respiratory failure and even death, with many patients being hospitalised with pneumonia. In China and East Asia, Chinese medicine has been widely used to treat diverse diseases for thousands of years. As an important means of treatment now, Chinese medicine plays a significant role in the treatment of respiratory diseases in China. The aim of this study is to assess the efficacy and safety of Chinese medicine for COVID-19.
    Methods: We will search the following sources for the identification of trials: The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure Database (CNKI), Chinese Science and Technique Journals Database (VIP), and the Wanfang Database. All the above databases will be searched from the available date of inception until the latest issue. No language or publication restriction will be used. Randomized controlled trials will be included if they recruited participants with COVID-19 for assessing the effect of Chinese medicine vs control (placebo, no treatment, and other therapeutic agents). Primary outcomes will include chest CT and nucleic acid detection of respiratory samples. Two authors will independently scan the articles searched, extract the data from articles included, and assess the risk of bias by Cochrane tool of risk of bias. Disagreements will be resolved by consensus or the involvement of a third party. All analysis will be performed based on the Cochrane Handbook for Systematic Reviews of Interventions. Dichotomous variables will be reported as risk ratio or odds ratio with 95% confidence intervals (CIs) and continuous variables will be summarized as mean difference or standard mean difference with 95% CIs.
    Results and conclusion: The available evidence of the treatment of COVID-19 with traditional Chinese medicine will be summarized, and evaluation of the efficacy and the adverse effects of these treatments will be made. This review will be disseminated in print by peer-review.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Medicine, Chinese Traditional/adverse effects ; Meta-Analysis as Topic ; Pandemics ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Systematic Reviews as Topic
    Keywords covid19
    Language English
    Publishing date 2020-06-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000020660
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Therapy of diarrhea in COVID-19 with external treatment of traditional Chinese medicine: A protocol for systematic review and meta-analysis.

    Cheng, Cheng / Huang, Yashuang / Xie, Li / Zhu, Xinghui / Chen, Dongmei / Cheng, Cisong

    Medicine

    2021  Volume 100, Issue 1, Page(s) e24120

    Abstract: ... of traditional Chinese medicine therapy for COVID-19 with diarrhea is the primary purpose of this systematic evaluation program ... of traditional Chinese medicine is an effective and safe intervention for coronavirus disease 2019 with diarrhea.: Registration ... The assessment of risk of bias and data synthesis will be carried out using Review Manager Software V.5.3 ...

    Abstract Background: Evaluating the effectiveness and safety of external treatment of traditional Chinese medicine therapy for COVID-19 with diarrhea is the primary purpose of this systematic evaluation program.
    Methods: We will search the randomized controlled trials from inception to November 2020. The following database is our focus area: Cochrane Central Register of Controlled Trials, Embase, PubMed, Web of Science, China National Knowledge Infrastructure (CNKI), Chinese Biomedical Database (CBM), VIP database for Chinese technical Periodicals, and Wanfang Database. We will choose articles published both in Chinese and English. Two reviewers will conduct the study selection, data extraction, and assessment independently. The assessment of risk of bias and data synthesis will be carried out using Review Manager Software V.5.3.
    Results: The results will provide high-quality synthesis of current evidence for researchers in this subject area.
    Conclusion: This studys decision will provide evidence of whether external treatment of traditional Chinese medicine is an effective and safe intervention for coronavirus disease 2019 with diarrhea.
    Registration number: INPLASY2020110095 (DOI number: 10.37766/inplasy2020.11.0095).
    MeSH term(s) COVID-19/therapy ; Diarrhea/therapy ; Diarrhea/virology ; Humans ; Medicine, Chinese Traditional ; Research Design ; SARS-CoV-2
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000024120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chinese medicine for COVID-19 ; A protocol for systematic review and meta-analysis

    Chen, Huizhen / Xie, Ziyan / Zhu, Yuxia / Chen, Qiu / Xie, Chunguang

    Medicine

    2020  Volume 99, Issue 25, Page(s) e20660

    Keywords General Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/md.0000000000020660
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Chinese medicine for COVID-19: A protocol for systematic review and meta-analysis

    Chen, Huizhen / Xie, Ziyan / Zhu, Yuxia / Chen, Qiu / Xie, Chunguang

    Medicine (Baltimore)

    Abstract: ... of COVID-19 with traditional Chinese medicine will be summarized, and evaluation of the efficacy and ... of respiratory diseases in China. The aim of this study is to assess the efficacy and safety of Chinese medicine for COVID ... if they recruited participants with COVID-19 for assessing the effect of Chinese medicine vs control (placebo, no ...

    Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. The virus that causes COVID-19 is a novel coronavirus that was first identified during an investigation into an outbreak in Wuhan, China. The clinical spectrum of SARS-CoV-2 infection appears to be wide, encompassing asymptomatic infection, mild upper respiratory tract illness, and severe viral pneumonia with respiratory failure and even death, with many patients being hospitalised with pneumonia. In China and East Asia, Chinese medicine has been widely used to treat diverse diseases for thousands of years. As an important means of treatment now, Chinese medicine plays a significant role in the treatment of respiratory diseases in China. The aim of this study is to assess the efficacy and safety of Chinese medicine for COVID-19. METHODS: We will search the following sources for the identification of trials: The Cochrane Library, PubMed, EMBASE, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure Database (CNKI), Chinese Science and Technique Journals Database (VIP), and the Wanfang Database. All the above databases will be searched from the available date of inception until the latest issue. No language or publication restriction will be used. Randomized controlled trials will be included if they recruited participants with COVID-19 for assessing the effect of Chinese medicine vs control (placebo, no treatment, and other therapeutic agents). Primary outcomes will include chest CT and nucleic acid detection of respiratory samples. Two authors will independently scan the articles searched, extract the data from articles included, and assess the risk of bias by Cochrane tool of risk of bias. Disagreements will be resolved by consensus or the involvement of a third party. All analysis will be performed based on the Cochrane Handbook for Systematic Reviews of Interventions. Dichotomous variables will be reported as risk ratio or odds ratio with 95% confidence intervals (CIs) and continuous variables will be summarized as mean difference or standard mean difference with 95% CIs. RESULTS AND CONCLUSION: The available evidence of the treatment of COVID-19 with traditional Chinese medicine will be summarized, and evaluation of the efficacy and the adverse effects of these treatments will be made. This review will be disseminated in print by peer-review.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #607008
    Database COVID19

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  6. Article ; Online: Efficacy and safety of Chinese patent medicine injection for COVID-19: A protocol for systematic review and meta-analysis.

    Lu, Meiqi / Lu, Zhen / Zhang, Ting / Wang, Wei / Xue, Ye / Cao, Zhiqun

    Medicine

    2020  Volume 99, Issue 25, Page(s) e20706

    Abstract: ... the efficacy and safety of Chinese patent medicine injection in the treatment of COVID-19.: Methods ... against the COVID-19. The contribution of traditional Chinese medicine can not be ignored. As a kind ... All randomized controlled trials of Chinese patent medicine injection for COVID-19 will be included. The following electronic ...

    Abstract Background: Corona Virus Disease 2019 (COVID-19) has caused a worldwide epidemic since its discovery. The outbreak of virus infection has aroused great concern of the World Health Organization (WHO). COVID-19 is highly infectious and has a high infection rate. So far, no specific drug has been found to cure it. China as one of the first countries attacked by epidemic has shown outstanding in fighting against the COVID-19. The contribution of traditional Chinese medicine can not be ignored. As a kind of representative of traditional Chinese medicine, the Chinese patent medicine injection has significant effect in reducing the clinical symptoms of patients and preventing the deterioration of the disease. However, there is no systematic review of its efficacy and safety. The purpose of this study is to evaluate the efficacy and safety of Chinese patent medicine injection in the treatment of COVID-19.
    Methods: All randomized controlled trials of Chinese patent medicine injection for COVID-19 will be included. The following electronic databases will be searched: PubMed, Web of Science, the Cochrane Library, EMBASE, China National Knowledge Infrastructure, Wanfang Database, Chinese Scientific Journal Database, Chinese Biomedical Literature database and some clinical trial registration websites. Two researchers will independently screen titles, abstracts, full texts, and extract data, then assess the bias risk of each study. We will conduct meta-analyses to assess all the available evidence of the efficacy and safety.
    Results: Systematic review of current evidence will be provided from the indexes of efficacy and safety.
    Conclusion: Evidence regarding the efficacy and safety of Chinese patent medicine injection in the treatment of COVID-19 will be provided to clinicians.PROSPERO registration number: CRD42020182725.
    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Humans ; Injections ; Meta-Analysis as Topic ; Pandemics ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; Systematic Reviews as Topic
    Chemical Substances Drugs, Chinese Herbal
    Keywords covid19
    Language English
    Publishing date 2020-06-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000020706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Traditional Chinese herbal medicine for treating novel coronavirus (COVID-19) pneumonia: protocol for a systematic review and meta-analysis.

    Li, Yuxi / Liu, Xiaobo / Guo, Liuxue / Li, Juan / Zhong, Dongling / Zhang, Yonggang / Clarke, Mike / Jin, Rongjiang

    Systematic reviews

    2020  Volume 9, Issue 1, Page(s) 75

    Abstract: ... traditional Chinese herbal medicine is being used for its treatment. This systematic review and meta-analysis ... to COVID-19 and traditional Chinese herbal medicine. Reference lists of relevant trials and reviews will be ... will assess studies of the effects of traditional Chinese herbal medicine in COVID-19 pneumonia.: Methods ...

    Abstract Background: A new type of coronavirus, novel coronavirus (COVID-19), is causing an increasing number of cases of pneumonia and was declared a Public Health Emergency of International Concern by the World Health Organization on 30 January 2020. The virus first appeared in Wuhan, China, in late December 2019, and traditional Chinese herbal medicine is being used for its treatment. This systematic review and meta-analysis will assess studies of the effects of traditional Chinese herbal medicine in COVID-19 pneumonia.
    Methods: We will search electronic databases including PubMed, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Chinese Science and Technology Periodical Database (VIP), and Wanfang database using keywords related to COVID-19 and traditional Chinese herbal medicine. Reference lists of relevant trials and reviews will be searched. We will manually search gray literature, such as conference proceedings and academic degree dissertations, and trial registries. Two independent reviewers will screen studies (XL and DZ), extract data (YL and LG), and evaluate risk of bias (YL and DZ). Data analysis will be conducted using the Review Manager software (version 5.3.5) and R software (version 3.6.1). Statistical heterogeneity will be assessed using a standard chi-square test with a significance level of P < 0.10. Biases associated with study size (e.g., publication bias) will be investigated using funnel plots, Egger's test and Begg's test, and Trim and Fill analysis.
    Discussion: This study will provide a high-quality synthesis of the effects of traditional Chinese herbal medicine for COVID-19. The use of traditional Chinese herbal medicine for treatment or prevention of these novel viral infections affecting the pneumonia will be investigated.
    Systematic review registration: PROSPERO registration number: CRD42020168004.
    MeSH term(s) Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional ; Meta-Analysis as Topic ; Pandemics/prevention & control ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; SARS-CoV-2 ; Systematic Reviews as Topic ; COVID-19 Drug Treatment
    Chemical Substances Drugs, Chinese Herbal
    Keywords covid19
    Language English
    Publishing date 2020-04-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2662257-9
    ISSN 2046-4053 ; 2046-4053
    ISSN (online) 2046-4053
    ISSN 2046-4053
    DOI 10.1186/s13643-020-01343-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Internal treatment in traditional Chinese medicine for patients with COVID-19: A protocol for systematic review and meta-analysis.

    Zhang, Mingxu / Huang, Ju / Wu, Xinhui / Lv, Lizeyu / Huang, Anming / Zhu, Siquan

    Medicine

    2020  Volume 99, Issue 51, Page(s) e23739

    Abstract: ... review and meta-analysis.: Methods: The following online databases will be searched from inception ... TCM) on Corona Virus Disease 2019 (COVID-19) is the main subject of this protocol for systematic ... in English or Chinese related to Internal Treatment in Traditional Chinese Medicine for COVID-19 will be ...

    Abstract Background: The safety and effectiveness of Internal Treatment in Traditional Chinese Medicine (TCM) on Corona Virus Disease 2019 (COVID-19) is the main subject of this protocol for systematic review and meta-analysis.
    Methods: The following online databases will be searched from inception to April 2020: Cochrane Central Register of Controlled Trials, PubMed, Web of Science, EMBASE, China National Knowledge Infrastructure, Traditional Chinese Medicine, Chinese Biomedical Literature Database, Wan-Fang Database, and Chinese Scientific Journal Database. All published randomized controlled trials in English or Chinese related to Internal Treatment in Traditional Chinese Medicine for COVID-19 will be included. Primary outcomes are time of disappearance of main symptoms and serum cytokine levels. Secondary outcomes is Accompanying symptoms disappear rate, negative COVID-19 results rate on 2 consecutive occasions CT image improvement, average hospitalization time, occurrence rate of common type to severe form, clinical cure rate, and mortality. Two reviewers will conduct the study selection, data extraction, and assessment independently. The assessment of risk of bias and data synthesis will be conducted with Review Manager Software V.5.2.
    Results: The results will provide a high-quality synthesis of current evidence for researchers in this subject area.
    Conclusion: The conclusion of our study will provide evidence to judge whether the internal treatment in traditional Chinese medicine is an effective intervention for COVID-19 patients.
    Prospero registration number: CRD42020180178.
    MeSH term(s) COVID-19/drug therapy ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional ; Meta-Analysis as Topic ; Systematic Reviews as Topic
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2020-12-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000023739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: External treatment of traditional Chinese medicine for COVID-19: A protocol for systematic review and meta-analysis.

    Wu, Liu / Yuan, Qiang / Kuang, Yongbing / Chen, Yong / Li, Jin / Feng, Yinhao / Luo, Jian

    Medicine

    2020  Volume 99, Issue 39, Page(s) e22316

    Abstract: ... the influence of external treatment of traditional Chinese medicine on the patients with COVID-19. Secondary ... of traditional Chinese medicine is an effective intervention on the patients with COVID-19.: Prospero registration number ... etc) and COVID-19 from inception to June 2020. The following database is our focus area: the Cochrane ...

    Abstract Background: There is a worldwide outbreak of COVID-19, as the number of patients increases. External treatment of traditional Chinese medicine includes acupuncture, massage, fire needle, cupping, and other alternative therapies. Currently, there are no relevant articles for systematic review.
    Methods: We will search the randomized controlled trials related to the external treatment of traditional Chinese medicine (such as, acupuncture, massage, etc) and COVID-19 from inception to June 2020. The following database is our focus area: the Cochrane Central Register of Controlled Trials (CENTRAL), PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, and Wan-Fang Database. All published randomized controlled trials in English or Chinese related to massage for COVID-19 will be included. Primary outcomes include the influence of external treatment of traditional Chinese medicine on the patients with COVID-19. Secondary outcomes include accompanying symptoms (such as myalgia, expectoration, stuffiness, runny nose, pharyngalgia, anhelation, chest distress, dyspnea, crackles, headache, nausea, vomiting, anorexia, diarrhea) disappear rate, negative COVID-19 results rate on 2 consecutive occasions (not on the same day), average hospitalization time, Clinical curative effect, and improved quality of life.
    Results: The results will provide a high-quality synthesis of current evidence for researchers in this subject area.
    Conclusion: The conclusion of our study will provide evidence to judge whether external treatment of traditional Chinese medicine is an effective intervention on the patients with COVID-19.
    Prospero registration number: CRD42020181336.
    MeSH term(s) Age Factors ; Betacoronavirus ; Body Weights and Measures ; COVID-19 ; Coronavirus Infections/therapy ; Humans ; Medicine, Chinese Traditional/methods ; Pandemics ; Pneumonia, Viral/therapy ; Quality of Life ; Randomized Controlled Trials as Topic ; Research Design ; SARS-CoV-2 ; Sex Factors ; Meta-Analysis as Topic ; Systematic Review as Topic
    Keywords covid19
    Language English
    Publishing date 2020-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000022316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Traditional Chinese medicine formula Xiaoqinglong decoction for cough caused by COVID-19: A protocol for a systematic review and meta-analysis.

    Ren, Xiaodan / Shi, Yu / Li, Guizhong

    Medicine

    2020  Volume 99, Issue 48, Page(s) e23261

    Abstract: ... Xiaoqinglong decoction for cough caused by COVID-19 is the main purpose of this systematic review protocol ... by COVID-19 will be included. The primary outcome is the time and rate of appearance of coughing ... for patients with cough caused by COVID-19.: Ethics and dissemination: Formal ethical approval is not ...

    Abstract Background: Assessing the effectiveness and safety of Traditional Chinese medicine formula Xiaoqinglong decoction for cough caused by COVID-19 is the main purpose of this systematic review protocol.
    Methods: The following electronic databases will be searched from their respective inception dates to October 1, 2020: PubMed, MEDLINE, the Cochrane Library, Embase, WorldSciNet, Ovid, the Allied and Complementary Medicine Database, the Web of Science, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, the Chongqing VIP Chinese Science and Technology Periodical Database (VIP), the Wanfang Database, and the China Biology Medicine Disc. All published randomized controlled trials in English or Chinese related to Traditional Chinese medicine formula Xiaoqinglong decoction for cough caused by COVID-19 will be included. The primary outcome is the time and rate of appearance of coughing. The secondary outcomes are the length of hospital stay. Two reviewers will conduct the study selection, data extraction, and assessment independently. The assessment of risk of bias and data synthesis will be conducted with RevMan V.5.2.
    Results: The results will provide a high-quality synthesis of current evidence for researchers in this subject area.
    Conclusion: The conclusion of our study will provide an evidence to judge whether traditional Chinese medicine formula Xiaoqinglong decoction is an effective intervention for patients with cough caused by COVID-19.
    Ethics and dissemination: Formal ethical approval is not necessary as the data cannot be individualized. The results of this protocol will be disseminated in a peer-reviewed journal or presented at relevant conferences.
    Prospero registration number: CRD42020202079.
    MeSH term(s) Cough/drug therapy ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Drugs, Chinese Herbal/therapeutic use ; Humans ; Pandemics ; Randomized Controlled Trials as Topic ; Research Design ; SARS-CoV-2 ; COVID-19 Drug Treatment ; Meta-Analysis as Topic ; Systematic Review as Topic
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2020-11-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000023261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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