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  1. TI=N6 methyladenosine regulates PEDV replication and host gene expression
  2. AU="Giovanni Monteleone"

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  1. Artikel ; Online: N6-methyladenosine regulates PEDV replication and host gene expression.

    Chen, Jianing / Jin, Li / Wang, Zemei / Wang, Liyuan / Chen, Qingbo / Cui, Yaru / Liu, Guangliang

    Virology

    2020  Band 548, Seite(n) 59–72

    Abstract: Methylation of the N6 position of adenosine (m ...

    Abstract Methylation of the N6 position of adenosine (m
    Mesh-Begriff(e) Adenosine/analogs & derivatives ; Adenosine/metabolism ; Animals ; Cell Line ; Chlorocebus aethiops ; Coronavirus Infections/veterinary ; Gene Expression Regulation ; Genome, Viral ; Host-Pathogen Interactions/genetics ; Methylation ; Porcine epidemic diarrhea virus/physiology ; Porcine epidemic diarrhea virus/ultrastructure ; Protein Binding ; RNA, Viral ; RNA-Binding Proteins/metabolism ; Swine ; Swine Diseases/genetics ; Swine Diseases/virology ; Vero Cells ; Virus Replication
    Chemische Substanzen RNA, Viral ; RNA-Binding Proteins ; N-methyladenosine (CLE6G00625) ; Adenosine (K72T3FS567)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-16
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2020.06.008
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: N6-methyladenosine regulates PEDV replication and host gene expression

    Chen, Jianing / Jin, Li / Wang, Zemei / Wang, Liyuan / Chen, Qingbo / Cui, Yaru / Liu, Guangliang

    Virology. 2020 Sept., v. 548

    2020  

    Abstract: ... in mRNAs and target genes were also altered during PEDV infection. Additionally, part of the host responses ... Taken together, our results identified the role of m⁶A modification in PEDV replication and interactions ... could trigger an increasement of m⁶A in host RNA and decrease the expression of FTO. The m⁶A modification sites ...

    Abstract Methylation of the N6 position of adenosine (m⁶A) is a widespread RNA modification that is critical for various physiological and pathological processes. Although this modification was also found in the RNA of several viruses almost 40 years ago, its biological functions during viral infection have been elucidated recently. Here, we investigated the effects of viral and host RNA methylation during porcine epidemic diarrhea virus (PEDV) infection. The results demonstrated that the m⁶A modification was abundant in the PEDV genome and the host methyltransferases METTL3 and METTL14 and demethylase FTO were involved in the regulation of viral replication. The knockdown of the methyltransferases increased PEDV replication while silencing the demethylase decreased PEDV output. Moreover, the proteins of the YTHDF family regulated the PEDV replication by affecting the stability of m⁶A-modified viral RNA. In particular, PEDV infection could trigger an increasement of m⁶A in host RNA and decrease the expression of FTO. The m⁶A modification sites in mRNAs and target genes were also altered during PEDV infection. Additionally, part of the host responses to PEDV infection was controlled by m⁶A modification, which could be reversed by the expression of FTO. Taken together, our results identified the role of m⁶A modification in PEDV replication and interactions with the host.
    Schlagwörter Porcine epidemic diarrhea virus ; adenosine ; gene expression ; methylation ; methyltransferases ; virus replication
    Sprache Englisch
    Erscheinungsverlauf 2020-09
    Umfang p. 59-72.
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 200425-2
    ISSN 1096-0341 ; 0042-6822
    ISSN (online) 1096-0341
    ISSN 0042-6822
    DOI 10.1016/j.virol.2020.06.008
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

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  3. Artikel: N6-methyladenosine regulates PEDV replication and host gene expression

    Chen, J. / Jin, L. / Wang, Z. / Wang, L. / Chen, Q. / Cui, Y. / Liu, G.

    Virology

    Abstract: ... modification in PEDV replication and interactions with the host Copyright © 2020 Elsevier Inc ... in the PEDV genome and the host methyltransferases METTL3 and METTL14 and demethylase FTO were involved ... infection could trigger an increasement of msup6/supA in host RNA and decrease the expression of FTO ...

    Abstract Methylation of the N6 position of adenosine (msup6/supA) is a widespread RNA modification that is critical for various physiological and pathological processes Although this modification was also found in the RNA of several viruses almost 40 years ago, its biological functions during viral infection have been elucidated recently Here, we investigated the effects of viral and host RNA methylation during porcine epidemic diarrhea virus (PEDV) infection The results demonstrated that the msup6/supA modification was abundant in the PEDV genome and the host methyltransferases METTL3 and METTL14 and demethylase FTO were involved in the regulation of viral replication The knockdown of the methyltransferases increased PEDV replication while silencing the demethylase decreased PEDV output Moreover, the proteins of the YTHDF family regulated the PEDV replication by affecting the stability of msup6/supA-modified viral RNA In particular, PEDV infection could trigger an increasement of msup6/supA in host RNA and decrease the expression of FTO The msup6/supA modification sites in mRNAs and target genes were also altered during PEDV infection Additionally, part of the host responses to PEDV infection was controlled by msup6/supA modification, which could be reversed by the expression of FTO Taken together, our results identified the role of msup6/supA modification in PEDV replication and interactions with the host Copyright © 2020 Elsevier Inc
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #617875
    Datenquelle COVID19

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