Article ; Online: TRPM7 channel inhibition mediates midazolam-induced proliferation loss in human malignant glioma.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
2016 Volume 37, Issue 11, Page(s) 14721–14731
Abstract: ... we identified the characteristic TRPM7 channel currents in human malignant glioma MGR2 cells, which could be ... The melastatin-like transient receptor potential 7 (TRPM7) has been implicated in proliferation or ... apoptosis of some cancers, indicating the potential of TRPM7 as an anti-anaplastic target. Here ...
| Abstract | The melastatin-like transient receptor potential 7 (TRPM7) has been implicated in proliferation or apoptosis of some cancers, indicating the potential of TRPM7 as an anti-anaplastic target. Here, we identified the characteristic TRPM7 channel currents in human malignant glioma MGR2 cells, which could be blocked by a pharmacologic inhibitor Gd |
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| MeSH term(s) | Anti-Anxiety Agents/pharmacology ; Apoptosis/drug effects ; Blotting, Western ; Calcium/metabolism ; Cell Cycle/drug effects ; Cell Proliferation/drug effects ; Data Mining ; Databases, Factual ; Fluorescent Antibody Technique ; Glioma/drug therapy ; Glioma/metabolism ; Glioma/pathology ; Humans ; Image Processing, Computer-Assisted/methods ; Midazolam/pharmacology ; Protein-Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; Real-Time Polymerase Chain Reaction ; Reverse Transcriptase Polymerase Chain Reaction ; TRPM Cation Channels/antagonists & inhibitors ; TRPM Cation Channels/genetics ; TRPM Cation Channels/metabolism ; Tumor Cells, Cultured | |||||
| Chemical Substances | Anti-Anxiety Agents ; RNA, Messenger ; RNA, Small Interfering ; TRPM Cation Channels ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; TRPM7 protein, human (EC 2.7.11.1) ; Midazolam (R60L0SM5BC) ; Calcium (SY7Q814VUP) | |||||
| Language | English | |||||
| Publishing date | 2016-11 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 605825-5 | |||||
| ISSN | 1423-0380 ; 0289-5447 ; 1010-4283 | |||||
| ISSN (online) | 1423-0380 | |||||
| ISSN | 0289-5447 ; 1010-4283 | |||||
| DOI | 10.1007/s13277-016-5317-2 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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