Article ; Online: Clinical characteristics and outcomes of adult patients admitted with COVID-19 in East London: a retrospective cohort analysis.
2021 Volume 8, Issue 1
Abstract: ... Methods: A retrospective analysis was carried out on a cohort of 1946 patients with a clinical or ... Background: Descriptions of clinical characteristics of patients hospitalised withCOVID-19 ... of non-invasive ventilation and intensive care, mortality and short-term sequelae of patients admitted to two large District ...
| Abstract | Background: Descriptions of clinical characteristics of patients hospitalised withCOVID-19, their clinical course and short-term inpatient and outpatient outcomes in deprived urban populations in the UK are still relatively sparse. We describe the epidemiology, clinical course, experience of non-invasive ventilation and intensive care, mortality and short-term sequelae of patients admitted to two large District General Hospitals across a large East London National Health Service Trust during the first wave of the pandemic. Methods: A retrospective analysis was carried out on a cohort of 1946 patients with a clinical or laboratory diagnosis of COVID-19, including descriptive statistics and survival analysis. A more detailed analysis was undertaken of a subset of patients admitted across three respiratory units in the trust. Results: Increasing age, male sex and Asian ethnicity were associated with worse outcomes. Increasing severity of chest X-ray abnormalities trended with mortality. Radiological changes persisted in over 50% of cases at early follow-up (6 weeks). Ongoing symptoms including hair loss, memory impairment, breathlessness, cough and fatigue were reported in 70% of survivors, with 39% of patients unable to return to work due to ongoing symptoms. Conclusions: Understanding the acute clinical features, course of illness and outcomes of COVID-19 will be crucial in understanding the effect of differences in risk, as well as the effectiveness of new interventions and vaccination between the successive waves of the pandemic. |
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| MeSH term(s) | Age Factors ; Aged ; Aged, 80 and over ; Alopecia/physiopathology ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/physiopathology ; COVID-19/therapy ; Cohort Studies ; Cough/physiopathology ; Dyspnea/physiopathology ; Ethnic Groups ; Fatigue/physiopathology ; Female ; Hospital Mortality ; Humans ; Intensive Care Units/statistics & numerical data ; London/epidemiology ; Male ; Memory Disorders/physiopathology ; Middle Aged ; Multivariate Analysis ; Noninvasive Ventilation/statistics & numerical data ; Proportional Hazards Models ; Retrospective Studies ; Return to Work ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index ; Sex Factors |
| Language | English |
| Publishing date | 2021-03-17 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 2736454-9 |
| ISSN | 2052-4439 ; 2052-4439 |
| ISSN (online) | 2052-4439 |
| ISSN | 2052-4439 |
| DOI | 10.1136/bmjresp-2020-000813 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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