Article ; Online: Gastrointestinal bleeding in patients on novel oral anticoagulants: Risk, prevention and management.
World journal of gastroenterology
2017 Volume 23, Issue 11, Page(s) 1954–1963
Abstract: Novel oral anticoagulants (NOACs), which include direct thrombin inhibitor (dabigatran) and direct ... including gastrointestinal bleeding (GIB). Results from both randomized clinical trials and observations ... factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention ...
| Abstract | Novel oral anticoagulants (NOACs), which include direct thrombin inhibitor (dabigatran) and direct factor Xa inhibitors (rivaroxaban, apixaban and edoxaban), are gaining popularity in the prevention of embolic stroke in non-valvular atrial fibrillation as well as in the prevention and treatment of venous thromboembolism. However, similar to traditional anticoagulants, NOACs have the side effects of bleeding, including gastrointestinal bleeding (GIB). Results from both randomized clinical trials and observations studies suggest that high-dose dabigatran (150 mg b.i.d), rivaroxaban and high-dose edoxaban (60 mg daily) are associated with a higher risk of GIB compared with warfarin. Other risk factors of NOAC-related GIB include concomitant use of ulcerogenic agents, older age, renal impairment, |
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| MeSH term(s) | Administration, Oral ; Anticoagulants/administration & dosage ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Atrial Fibrillation/prevention & control ; Blood Coagulation Factors/agonists ; Blood Coagulation Factors/antagonists & inhibitors ; Clinical Trials as Topic ; Endoscopy, Gastrointestinal ; Gastrointestinal Hemorrhage/chemically induced ; Gastrointestinal Hemorrhage/prevention & control ; Gastrointestinal Hemorrhage/therapy ; Helicobacter Infections/complications ; Humans ; Peptic Ulcer/chemically induced ; Peptic Ulcer/complications ; Risk Factors ; Stroke/prevention & control | |||||
| Chemical Substances | Anticoagulants ; Blood Coagulation Factors | |||||
| Language | English | |||||
| Publishing date | 2017-02-11 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Review | |||||
| ZDB-ID | 2185929-2 | |||||
| ISSN | 2219-2840 ; 1007-9327 | |||||
| ISSN (online) | 2219-2840 | |||||
| ISSN | 1007-9327 | |||||
| DOI | 10.3748/wjg.v23.i11.1954 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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