Article ; Online: Clinical evaluation of serological IgG antibody response on the Abbott Architect for established SARS-CoV-2 infection.
2020 Volume 26, Issue 9, Page(s) 1256.e9–1256.e11
Abstract: ... 57; 71.6-92.1%).: Conclusion: The Abbott SARS-CoV-2 IgG test has high specificity. Clinical ... positive patients and 163 non-COVID-19 patients were tested for antibody with the Abbott SARS-CoV-2 IgG ... CoV-2 IgG assay in COVID-19 patients.: Methods: Residual sera from 177 symptomatic SARS-CoV-2 ...
| Abstract | Objective: This study aimed to evaluate the diagnostic performance of the Abbott Architect SARS-CoV-2 IgG assay in COVID-19 patients. Methods: Residual sera from 177 symptomatic SARS-CoV-2-positive patients and 163 non-COVID-19 patients were tested for antibody with the Abbott SARS-CoV-2 IgG assay (Abbott Diagnostics, Chicago, USA). Clinical records for COVID-19 patients were reviewed to determine the time from onset of clinical illness to testing. Results: Specificity of the assay was 100.0% (95%CI: 97.1-100.0%). The clinical sensitivity of the assay varied depending on time from onset of symptoms, increasing with longer periods from the onset of clinical illness. The clinical sensitivity at ≤6 days was 8.6% (7/81; 95%CI: 3.8-17.5%), at 7-13 days 43.6% (17/39; 95%CI: 28.2-60.2%), at 14-20 days 84.0% (21/25; 95%CI: 63.1-94.7%), and at ≥21 days 84.4% (27/32; 95%CI: 66.5-94.1%). Clinical sensitivity was higher in the ≥14-day group compared to <14 days. There were no differences between the 14-20-day and ≥21-days groups; the combined clinical sensitivity for these groups (≥14 days) was 84.2% (49/57; 71.6-92.1%). Conclusion: The Abbott SARS-CoV-2 IgG test has high specificity. Clinical sensitivity was limited in the early stages of disease but improved from 14 days after the onset of clinical symptoms. |
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| MeSH term(s) | Antibodies, Viral/blood ; Antibody Formation ; COVID-19/diagnosis ; COVID-19 Serological Testing/methods ; Humans ; Immunoglobulin G/blood ; Sensitivity and Specificity ; Singapore ; Time Factors |
| Chemical Substances | Antibodies, Viral ; Immunoglobulin G |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-06-09 |
| Publishing country | England |
| Document type | Evaluation Study ; Journal Article |
| ZDB-ID | 1328418-6 |
| ISSN | 1469-0691 ; 1470-9465 ; 1198-743X |
| ISSN (online) | 1469-0691 |
| ISSN | 1470-9465 ; 1198-743X |
| DOI | 10.1016/j.cmi.2020.05.036 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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