Article ; Online: Hyperactivated RAGE in Comorbidities as a Risk Factor for Severe COVID-19-The Role of RAGE-RAS Crosstalk.
2021 Volume 11, Issue 6
Abstract: ... inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential ... injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be ... The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role ...
| Abstract | The receptor for advanced glycation-end products (RAGE) is a multiligand receptor with a role in inflammatory and pulmonary pathologies. Hyperactivation of RAGE by its ligands has been reported to sustain inflammation and oxidative stress in common comorbidities of severe COVID-19. RAGE is essential to the deleterious effects of the renin-angiotensin system (RAS), which participates in infection and multiorgan injury in COVID-19 patients. Thus, RAGE might be a major player in severe COVID-19, and appears to be a useful therapeutic molecular target in infections by SARS-CoV-2. The role of RAGE gene polymorphisms in predisposing patients to severe COVID-19 is discussed. . |
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| MeSH term(s) | Animals ; COVID-19/genetics ; COVID-19/metabolism ; COVID-19/pathology ; Humans ; Inflammation/genetics ; Inflammation/metabolism ; Inflammation/pathology ; Oxidative Stress ; Polymorphism, Genetic ; Receptor for Advanced Glycation End Products/genetics ; Receptor for Advanced Glycation End Products/metabolism ; Renin-Angiotensin System ; Risk Factors ; SARS-CoV-2/physiology ; Severity of Illness Index |
| Chemical Substances | Receptor for Advanced Glycation End Products |
| Language | English |
| Publishing date | 2021-06-12 |
| Publishing country | Switzerland |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
| ZDB-ID | 2701262-1 |
| ISSN | 2218-273X ; 2218-273X |
| ISSN (online) | 2218-273X |
| ISSN | 2218-273X |
| DOI | 10.3390/biom11060876 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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