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  1. Article ; Online: Persistence of Neutralizing Antibody Response up to 1 Year After Asymptomatic or Symptomatic SARS-CoV-2 Infection.

    Choe, Pyoeng Gyun / Kang, Chang Kyung / Kim, Kye-Hyung / Yi, Jongyoun / Kim, Eu Suk / Park, San Won / Kim, Nam Joong / Park, Wan Beom / Oh, Myoung-Don

    The Journal of infectious diseases

    2021  Volume 224, Issue 6, Page(s) 1097–1099

    MeSH term(s) Antibodies, Neutralizing ; Antibodies, Viral ; Antibody Formation ; COVID-19 ; Humans ; SARS-CoV-2
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral
    Language English
    Publishing date 2021-12-31
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiab339
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity.

    Altmann, Daniel M / Reynolds, Catherine J / Joy, George / Otter, Ashley D / Gibbons, Joseph M / Pade, Corinna / Swadling, Leo / Maini, Mala K / Brooks, Tim / Semper, Amanda / McKnight, Áine / Noursadeghi, Mahdad / Manisty, Charlotte / Treibel, Thomas A / Moon, James C / Boyton, Rosemary J

    Nature communications

    2023  Volume 14, Issue 1, Page(s) 5139

    Abstract: ... asymptomatic SARS-CoV-2 infection during the first wave. Symptom questionnaires allow stratification ... SARS-CoV-2 humoral and cellular immunity in 86 healthcare workers with laboratory confirmed mild or ... responses. Also, there is no difference in the profile of antibody waning. Analysis at 1-year, after two ...

    Abstract Among the unknowns in decoding the pathogenesis of SARS-CoV-2 persistent symptoms in Long Covid is whether there is a contributory role of abnormal immunity during acute infection. It has been proposed that Long Covid is a consequence of either an excessive or inadequate initial immune response. Here, we analyze SARS-CoV-2 humoral and cellular immunity in 86 healthcare workers with laboratory confirmed mild or asymptomatic SARS-CoV-2 infection during the first wave. Symptom questionnaires allow stratification into those with persistent symptoms and those without for comparison. During the period up to 18-weeks post-infection, we observe no difference in antibody responses to spike RBD or nucleoprotein, virus neutralization, or T cell responses. Also, there is no difference in the profile of antibody waning. Analysis at 1-year, after two vaccine doses, comparing those with persistent symptoms to those without, again shows similar SARS-CoV-2 immunity. Thus, quantitative differences in these measured parameters of SARS-CoV-2 adaptive immunity following mild or asymptomatic acute infection are unlikely to have contributed to Long Covid causality. ClinicalTrials.gov (NCT04318314).
    MeSH term(s) Humans ; Antibodies, Viral ; Asymptomatic Infections ; COVID-19 ; Post-Acute COVID-19 Syndrome ; SARS-CoV-2 ; T-Lymphocytes
    Chemical Substances Antibodies, Viral
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Clinical Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-40460-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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