Article: Inorganic cytoplasmic inclusions in alveolar macrophages. The role of cigarette smoking.
Archives of pathology & laboratory medicine
1978 Volume 102, Issue 2, Page(s) 79–83
Abstract: ... and spectrometric analysis is reported. Abnormalities of the alveolar macrophages, which are ... particularly affected by tobacco inhalation were found. The size of the macrophages was increased and ... many large, polymorphous inclusions, including fat vacuoles and granular deposits, which were ...
Abstract | A case of tobacco-associated pulmonary fibrosis, with the results of histological, ultrastructural, and spectrometric analysis is reported. Abnormalities of the alveolar macrophages, which are particularly affected by tobacco inhalation were found. The size of the macrophages was increased and many large, polymorphous inclusions, including fat vacuoles and granular deposits, which were either homogeneous or electron lucent vacuoles, were seen in the cytoplasm. A few laminar structures were observed. All of these lesions are frequently found in cigarette smokers. Still more interesting was the discovery of numerous fiber-, needle-, or laminar-like inclusions that varied in size from 0.2 to more than 2 mu. The digestions of the inclusions with potassium hydroxide confirmed the presence of various metals, such as sodium, magnesium, potassium, iron, sulfur, and especially, aluminum, and silicon; these last two elements correspond to the presence of kaolinite in the tissue, as has been previously described, and can be considered as evidence of the use of tobacco. |
|||||
---|---|---|---|---|---|---|
MeSH term(s) | Aged ; Cytoplasmic Granules/analysis ; Cytoplasmic Granules/ultrastructure ; Humans ; Inclusion Bodies/ultrastructure ; Kaolin ; Macrophages/ultrastructure ; Male ; Microscopy, Electron ; Pulmonary Alveoli/pathology ; Pulmonary Fibrosis/pathology ; Smoking ; X-Ray Diffraction | |||||
Chemical Substances | Kaolin (24H4NWX5CO) | |||||
Language | English | |||||
Publishing date | 1978-02 | |||||
Publishing country | United States | |||||
Document type | Case Reports ; Journal Article | |||||
ZDB-ID | 194119-7 | |||||
ISSN | 1543-2165 ; 0003-9985 ; 0363-0153 ; 0096-8528 | |||||
ISSN (online) | 1543-2165 | |||||
ISSN | 0003-9985 ; 0363-0153 ; 0096-8528 | |||||
Shelf mark |
|
|||||
Database | MEDical Literature Analysis and Retrieval System OnLINE |
More links
Kategorien
In stock of ZB MED Cologne/Königswinter
Ud II Zs.36: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Order via subito
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.