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  1. Article ; Online: Chemokine expression in sera of patients with microscopic polyangiitis and granulomatosis with polyangiitis.

    Lee, Ji Eun / Yoon, Taejun / Lee, Sang-Won / Ahn, Sung Soo

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 8680

    Abstract: ... with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) (MPA/GPA). Serum CCL2, CCL4, CCL19, CXCL1, CXCL2 ...

    Abstract We evaluated chemokine expression and its correlation with disease activity in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) (MPA/GPA). Serum CCL2, CCL4, CCL19, CXCL1, CXCL2, and CX3CL1 level in 80 patients were analysed using multiple enzyme-linked immunosorbent assays. Correlations between variables were investigated using Pearson's correlation analysis, and receiver operator curve analysis was performed to identify optimal CX3CL1 values in determining active disease. Multivariate logistic regression analysis was done to evaluate predictors of active disease. CCL4 (r = 0.251, p = 0.025), CXCL1 (r = 0.270, p = 0.015), and CX3CL1 (r = 0.295, p = 0.008) significantly correlated with BVAS, while CX3CL1 was associated with five-factor score (r =  - 0.290, p = 0.009). Correlations were revealed between CCL2 and CCL4 (r = 0.267, p = 0.017), CCL4 and CXCL1 (r = 0.368, p < 0.001), CCL4 and CXCL2 (r = 0.436, p < 0.001), and CXCL1 and CXCL2 (r = 0.518, p < 0.001). Multivariate analysis revealed serum CX3CL1 levels > 2408.92 pg/mL could predict active disease (odds ratio, 27.401, p < 0.001). Serum chemokine levels of CCL4, CXCL1, and CX3CL1 showed association with disease activity and especially, CX3CL1 > 2408.92 pg/mL showed potential in predicting active MPA/GPA.
    MeSH term(s) Humans ; Microscopic Polyangiitis ; Granulomatosis with Polyangiitis ; Multivariate Analysis ; Antibodies, Antineutrophil Cytoplasmic
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-59484-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Granulomatose mit Polyangiitis und mikroskopische Polyangiitis.

    Klapa, Sebastian / Arnold, Sabrina / Lamprecht, Peter

    Laryngo- rhino- otologie

    2024  

    Abstract: Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are two entities of ANCA ...

    Title translation Granulomatosis with polyangiitis and microscopic polyangiitis.
    Abstract Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are two entities of ANCA-associated vasculitis (AAV). Both diseases are characterised by systemic necrotising small-vessel vasculitis, which can affect any organ. In GPA, extravascular necrotising granulomatous inflammation, usually affecting the respiratory tract, is found in addition. In the majority of cases, the clinical presentation is dominated by a pulmonary-renal syndrome with alveolar haemorrhage and rapidly progressive glomerulonephritis. Other organ involvement is found as well. In GPA, the upper respiratory tract is commonly affected. GPA is associated with anti-neutrophil cytoplasmic autoantibodies (ANCA) with specificity for proteinase 3 (PR3-ANCA) and MPA with specificity for myeloperoxidase (MPO-ANCA). Immunosuppressive therapy depends on disease activity and the severity of organ involvement.
    Language German
    Publishing date 2024-01-11
    Publishing country Germany
    Document type English Abstract ; Journal Article
    ZDB-ID 96005-6
    ISSN 1438-8685 ; 0340-1588 ; 0935-8943
    ISSN (online) 1438-8685
    ISSN 0340-1588 ; 0935-8943
    DOI 10.1055/a-2217-4457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul II Zs.95: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  3. Article ; Online: Treatment Approaches to Granulomatosis with Polyangiitis and Microscopic Polyangiitis.

    Berti, Alvise / Cornec, Divi / Dua, Anisha B

    Rheumatic diseases clinics of North America

    2023  Volume 49, Issue 3, Page(s) 545–561

    Abstract: ... with granulomatosis with polyangiitis and microscopic polyangiitis. With increased understanding of the pathogenesis ...

    Abstract We have made significant headway in our ability to induce and maintain remission in patients with granulomatosis with polyangiitis and microscopic polyangiitis. With increased understanding of the pathogenesis of antineutrophilic cytoplasmic antibody-associated vasculitides (AAV), therapeutic targets have been identified and studied in clinical trials. From initial induction strategies including glucocorticoids and cyclophosphamide, we have discovered effective induction regimens with rituximab and complement inhibition that can significantly decrease the glucocorticoid cumulative doses in patients with AAV. There are many trials underway evaluating management strategies for refractory patients and exploring new and old therapies that may help to continuously improve outcomes for patients with AAV.
    MeSH term(s) Humans ; Microscopic Polyangiitis/drug therapy ; Granulomatosis with Polyangiitis/drug therapy ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/drug therapy ; Remission Induction ; Rituximab/therapeutic use ; Antibodies, Antineutrophil Cytoplasmic
    Chemical Substances Rituximab (4F4X42SYQ6) ; Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2023-04-28
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 92118-x
    ISSN 1558-3163 ; 0889-857X
    ISSN (online) 1558-3163
    ISSN 0889-857X
    DOI 10.1016/j.rdc.2023.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Microscopic polyangiitis.

    Tobiáš, Daniel / Brázdilová, Kristína / Killinger, Zdenko / Payer, Juraj

    Vnitrni lekarstvi

    2020  Volume 66, Issue 4, Page(s) 249–252

    Abstract: Microscopic polyangiitis is a rare, systemic, necrotizing, pauci-immune, ANCA associated small ... vessel vasculitis, with no evidence of granulomatous inflammation. Diagnosing microscopic polyangiitis is ...

    Title translation Mikroskopická polyangiitída.
    Abstract Microscopic polyangiitis is a rare, systemic, necrotizing, pauci-immune, ANCA associated small vessel vasculitis, with no evidence of granulomatous inflammation. Diagnosing microscopic polyangiitis is often difficult because of it´s presentation by a number of non-specific symptoms. We treated a 35-year old patient, who was admitted for migrating arthritis and fever with papulous rash. In this case, we want to point out the importance of considering the diagnosis of MPA and similar rare diseases in the process of differential diagnosis, mainly in patients presenting with non-specific symptoms, because the mortality of this disease without adequate treatment is alarmingly high.
    MeSH term(s) Adult ; Antibodies, Antineutrophil Cytoplasmic ; Diagnosis, Differential ; Glomerulonephritis/diagnosis ; Humans ; Microscopic Polyangiitis/diagnosis
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2020-09-25
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 138213-5
    ISSN 1801-7592 ; 0042-773X
    ISSN (online) 1801-7592
    ISSN 0042-773X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 327: Show issues Location:
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    Zs.MO 526: Show issues

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  5. Article ; Online: Risk factors of pulmonary relapse in microscopic polyangiitis and granulomatosis with polyangiitis.

    Villeneuve, T / Pugnet, G / Lauwers-Cances, V / Faguer, S / Prévot, G

    Pulmonology

    2023  Volume 30, Issue 1, Page(s) 85–86

    MeSH term(s) Humans ; Microscopic Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Lung ; Chronic Disease ; Risk Factors ; Recurrence
    Language English
    Publishing date 2023-07-21
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 3009651-0
    ISSN 2531-0437 ; 2531-0429
    ISSN (online) 2531-0437
    ISSN 2531-0429
    DOI 10.1016/j.pulmoe.2023.06.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Microscopic polyangiitis presenting with purpura and intermittent claudication.

    Ishizuka, Kosuke / Ohira, Yoshiyuki

    BMJ case reports

    2023  Volume 16, Issue 8

    MeSH term(s) Humans ; Microscopic Polyangiitis/complications ; Microscopic Polyangiitis/diagnosis ; Intermittent Claudication/etiology ; Granulomatosis with Polyangiitis ; Purpura/etiology ; Churg-Strauss Syndrome
    Language English
    Publishing date 2023-08-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2023-256363
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  7. Article ; Online: Score to assess the probability of relapse in granulomatosis with polyangiitis and microscopic polyangiitis.

    Samson, Maxime / Devilliers, Hervé / Thietart, Sara / Charles, Pierre / Pagnoux, Christian / Cohen, Pascal / Karras, Alexandre / Mouthon, Luc / Terrier, Benjamin / Puéchal, Xavier / Guillevin, Loic

    RMD open

    2023  Volume 9, Issue 1

    Abstract: ... with polyangiitis (GPA) and microscopic polyangiitis (MPA).: Methods: Long-term follow-up data from GPA and MPA ...

    Abstract Objective: To develop a score assessing the probability of relapse in granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA).
    Methods: Long-term follow-up data from GPA and MPA patients included in five consecutive randomised controlled trials were pooled. Patient characteristics at diagnosis were entered into a competing-risks model, with relapse as the event of interest and death the competing event. Univariate and multivariate analyses were computed to identify variables associated with relapse and build a score, which was then validated in an independent cohort of GPA or MPA patients.
    Results: Data collected from 427 patients (203 GPA, 224 MPA) at diagnosis were included. Mean±SD follow-up was 80.6±51.3 months; 207 (48.5%) patients experienced ≥1 relapse. Relapse risk was associated with proteinase 3 (PR3) positivity (HR=1.81 (95% CI 1.28 to 2.57); p<0.001), age ≤75 years (HR=1.89 (95% CI 1.15 to 3.13); p=0.012) and estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m² (HR=1.67 (95% CI 1.18 to 2.33); p=0.004) at diagnosis. A score, the French Vasculitis Study Group Relapse Score (FRS), from 0 to 3 points was modelised: 1 point each for PR3-antineutrophil cytoplasmic antibody positivity, eGFR ≥30 mL/min/1.73 m² and age ≤75 years. In the validation cohort of 209 patients, the 5-year relapse risk was 8% for a FRS of 0, 30% for 1, 48% for 2 and 76% for 3.
    Conclusion: The FRS can be used at diagnosis to assess the relapse risk in patients with GPA or MPA. Its value for tailoring the duration of maintenance therapy should be evaluated in future prospective trials.
    MeSH term(s) Humans ; Aged ; Microscopic Polyangiitis/diagnosis ; Microscopic Polyangiitis/epidemiology ; Microscopic Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/epidemiology ; Granulomatosis with Polyangiitis/complications ; Myeloblastin ; Probability ; Recurrence
    Chemical Substances Myeloblastin (EC 3.4.21.76)
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2812592-7
    ISSN 2056-5933 ; 2056-5933
    ISSN (online) 2056-5933
    ISSN 2056-5933
    DOI 10.1136/rmdopen-2022-002953
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Role of bronchoscopy for respiratory involvement in granulomatosis with polyangiitis and microscopic polyangiitis.

    Villeneuve, Thomas / Prévot, Grégoire / Pugnet, Grégory / Plat, Gavin / Héluain, Valentin / Faguer, Stanislas / Guibert, Nicolas

    ERJ open research

    2023  Volume 9, Issue 5

    Abstract: ... and 2019 in patients aged >18 years with a diagnosis of microscopic polyangiitis (MPA) or ... granulomatosis with polyangiitis (GPA) who underwent bronchoscopy at onset of the disease. We collected ...

    Abstract Objectives: This study describes data from bronchoscopy performed at the diagnosis of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV).
    Methods: We conducted a retrospective study between 2004 and 2019 in patients aged >18 years with a diagnosis of microscopic polyangiitis (MPA) or granulomatosis with polyangiitis (GPA) who underwent bronchoscopy at onset of the disease. We collected bronchoalveolar lavage (BAL) and histological findings obtained during bronchoscopy.
    Results: 274 patients with AAV were identified. Among 92 bronchoscopies, 62 were performed at diagnosis, and 58 procedures were finally analysed. Cough was more frequent in patients with MPA than GPA (p=0.02). The presence of endobronchial lesions (24.1%) was found to be significantly associated with GPA (p<0.0001) and proteinase 3-ANCA (p=0.01). The most frequent endobronchial lesions were inflammation and hyperaemia of the bronchial mucosa (50%), followed by stenoses (28%), ulcerations (21%) and mass-like granulomatosis (7%). The diagnostic yield of bronchial biopsies was useful for visible lesions (66.6%
    Conclusion: Bronchoscopy is an informative procedure at the onset of AAV disease in patients with respiratory manifestations. Endobronchial lesions are more frequently found in GPA and should be biopsied. BAL can be used to confirm DAH or diagnose superadded infection.
    Language English
    Publishing date 2023-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2827830-6
    ISSN 2312-0541
    ISSN 2312-0541
    DOI 10.1183/23120541.00141-2023
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  9. Article ; Online: Immune-mediated Necrotizing Myopathy in a Patient with Microscopic Polyangiitis.

    Umemoto, Daichi / Kanzawa, Yohei / Nakamura, Tomoko / Nishino, Ichizo / Mizuki, Shimpei / Ohnishi, Jun / Nakajima, Takahiro / Ishimaru, Naoto / Kinami, Saori

    Internal medicine (Tokyo, Japan)

    2023  Volume 63, Issue 10, Page(s) 1485–1490

    Abstract: ... with microscopic polyangiitis (MPA). A 77-year-old Japanese woman presented with a 2-day history of proximal muscle weakness and ...

    Abstract We herein report a case of immune-mediated necrotizing myopathy (IMNM) in a patient with microscopic polyangiitis (MPA). A 77-year-old Japanese woman presented with a 2-day history of proximal muscle weakness and myalgia, with elevated serum creatinine kinase (CK) levels. Findings of a muscle biopsy were compatible with IMNM; however, anti-signal recognition particle (SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibodies were negative. She also had peripheral neuropathy with elevated serum myeloperoxidase anti-neutrophil cytoplasmic antibody titers, leading to a diagnosis of MPA. IMNM can be a pathological result of MPA muscle involvement.
    MeSH term(s) Humans ; Female ; Aged ; Microscopic Polyangiitis/complications ; Microscopic Polyangiitis/diagnosis ; Microscopic Polyangiitis/immunology ; Necrosis ; Muscular Diseases/immunology ; Muscular Diseases/diagnosis ; Muscular Diseases/etiology ; Muscular Diseases/blood ; Antibodies, Antineutrophil Cytoplasmic/blood ; Antibodies, Antineutrophil Cytoplasmic/immunology ; Muscle, Skeletal/pathology
    Language English
    Publishing date 2023-10-06
    Publishing country Japan
    Document type Case Reports ; Journal Article
    ZDB-ID 32371-8
    ISSN 1349-7235 ; 0021-5120 ; 0918-2918
    ISSN (online) 1349-7235
    ISSN 0021-5120 ; 0918-2918
    DOI 10.2169/internalmedicine.2583-23
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 240: Show issues Location:
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  10. Article ; Online: Occupational Silica Exposure as a Potential Risk for Microscopic Polyangiitis.

    Alp, Alper / Ersoy, Melike / Meteoğlu, İbrahim / Kahraman Çetin, Nesibe / Akdam, Hakan / Yeniçerioğlu, Yavuz

    Wilderness & environmental medicine

    2023  Volume 34, Issue 4, Page(s) 543–548

    Abstract: Microscopic polyangiitis is an important and common component of cytoplasmic antibody-associated ... can cause microscopic polyangiitis. Working in occupations with increased risk of silica exposure may result ...

    Abstract Microscopic polyangiitis is an important and common component of cytoplasmic antibody-associated vasculitides that can lead to serious morbidity and even death. A clear causative etiology has not been identified. Although silica is well known to produce lung damage, the negative renal effects of silica exposure should not be overlooked. We present a case of renal dysfunction associated with silica exposure, its diagnosis by renal biopsy, and the treatment method used. Environmental or occupational silica exposure can cause microscopic polyangiitis. Working in occupations with increased risk of silica exposure may result in serious medical problems.
    MeSH term(s) Humans ; Silicon Dioxide/toxicity ; Microscopic Polyangiitis/etiology ; Occupational Exposure/adverse effects
    Chemical Substances Silicon Dioxide (7631-86-9)
    Language English
    Publishing date 2023-08-19
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1238909-2
    ISSN 1545-1534 ; 1080-6032
    ISSN (online) 1545-1534
    ISSN 1080-6032
    DOI 10.1016/j.wem.2023.06.012
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