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  1. Article: Pancreatic injury and acute pancreatitis in COVID-19 patients.

    Cienfuegos, Javier A / Almeida, Ana / Aliseda, Daniel

    Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva

    2021  Volume 113, Issue 5, Page(s) 389

    Abstract: ... acute pancreatitis (AP) reported in COVID-19 patients. In January 2021, a PubMed search using the terms ... of COVID-19 patients and AP in 1.8-2.0 % of these patients. ... Acute Pancreatitis, COVID-19" yielded a result including 94 studies. Most of the studies refer ...

    Abstract Apart from pulmonary manifestations, there is an increased incidence of pancreatic involvement and acute pancreatitis (AP) reported in COVID-19 patients. In January 2021, a PubMed search using the terms "Acute Pancreatitis, COVID-19" yielded a result including 94 studies. Most of the studies refer to isolated cases or limited series, with the added difficulty that some authors have considered AP as elevated lipase and/or amylase levels without the diagnostic criteria for AP being met, as highlighted by Chivato et al. in relation to the case they report. Pancreatic involvement has been reported in 17 % of COVID-19 patients and AP in 1.8-2.0 % of these patients.
    MeSH term(s) Acute Disease ; COVID-19 ; Humans ; Pancreas/diagnostic imaging ; Pancreatitis ; SARS-CoV-2
    Language English
    Publishing date 2021-02-10
    Publishing country Spain
    Document type Letter ; Comment
    ZDB-ID 1070381-0
    ISSN 1130-0108 ; 0212-7512
    ISSN 1130-0108 ; 0212-7512
    DOI 10.17235/reed.2021.7807/2021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Pancreatic Injury in COVID-19 Patients.

    Bansal, Priya / Margekar, Shubha Laxmi / Suman, Vivek / Sud, Ritika / Meena, Shivraj / Sharma, Amit K / Islam, Sheikh Yasir / Gurtoo, Anil / Agrawal, Aparna / Pangtey, Ghan Shyam / Prakash, Anupam

    The Journal of the Association of Physicians of India

    2020  Volume 68, Issue 12, Page(s) 58–60

    Abstract: ... of hyperamylasemia in patients of COVID-19 was 33%, while that of elevated lipase was 24.1%. Pancreatic injury failed ... amylase and serum lipase levels) in COVID-19 patients.: Methods: A retrospective study involving 42 ... COVID-19 patients (diagnosed by real-time PCR) admitted to a tertiary care hospital was conducted. Serum ...

    Abstract Background and aim: Coronavirus disease 2019 (COVID 2019) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may cause multisystem dysfunction. We studied pancreatic injury (serum amylase and serum lipase levels) in COVID-19 patients.
    Methods: A retrospective study involving 42 COVID-19 patients (diagnosed by real-time PCR) admitted to a tertiary care hospital was conducted. Serum amylase and serum lipase levels were analysed in relation to severity of COVID-19 and mortality.
    Results: Mean age of patients was 50 ± 16 years, with male to female ratio of 3.7:1. Serum amylase was elevated in 14 patients (33%). Serum lipase was elevated in 7 out of 29 patients (24.1%). Mortality was seen in 18 patients (42.8%). Serum amylase or lipase did not correlate with severity of COVID-19 or its mortality. However, both patients who had high lipase (>3times) died.
    Conclusion: The prevalence of hyperamylasemia in patients of COVID-19 was 33%, while that of elevated lipase was 24.1%. Pancreatic injury failed to show any statistically significant relation to severity or outcome of COVID-19.
    MeSH term(s) Adult ; Aged ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Female ; Humans ; Male ; Middle Aged ; Pancreas ; Pancreatic Diseases/virology ; Pandemics ; Pneumonia, Viral ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2020-11-28
    Publishing country India
    Document type Journal Article
    ZDB-ID 800766-4
    ISSN 0004-5772
    ISSN 0004-5772
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Investigation of factors affecting COVID-19 pancreatic injury: a single-center, retrospective study.

    Komatsu, Satoshi / Yatabe, Tomoaki / Hara, Yoshitaka / Kuriyama, Naohide / Nakamura, Tomoyuki / Nishida, Osamu

    Journal of anesthesia

    2023  Volume 37, Issue 3, Page(s) 487–491

    Abstract: ... It may be difficult to diagnose pancreatitis based on amylase and lipase levels in COVID-19 patients. ... patients, and 54 (31%) had pancreatic injuries. Of these three patients, acute pancreatitis was diagnosed ... of pancreatic injury in septic patients with COVID-19 was significantly higher than in those without COVID-19 ...

    Abstract Pancreatic injury is considered an organ-related complication in patients with coronavirus disease 2019 (COVID-19). However, it is unclear whether COVID-19 status affects pancreatic injury. This retrospective study aimed to determine whether COVID-19 affects the occurrence of pancreatic injuries. Consecutive patients diagnosed with sepsis admitted to the ICU between March 2020 and September 2021 were included. The primary endpoint was a pancreatic injury, which was defined as amylase or lipase levels > 3 times the upper limit of the normal range. Among the 177 patients included in the analysis, 40 (23%) were COVID-19 patients, and 54 (31%) had pancreatic injuries. Of these three patients, acute pancreatitis was diagnosed based on computed tomography. The pancreatic injury was significantly more common among COVID-19 patients (75 vs. 18%, p < 0.001). Multivariate analysis showed that COVID-19 and steroid use were independent risk factors for pancreatic injury (Odds Ratio (OR) 4.79 [95% confidence interval (CI) 1.48-15.5], p = 0.009; OR 4.02 [95% CI 1.42-11.4], p = 0.009). This study revealed that the proportion of pancreatic injury in septic patients with COVID-19 was significantly higher than in those without COVID-19. It may be difficult to diagnose pancreatitis based on amylase and lipase levels in COVID-19 patients.
    MeSH term(s) Humans ; Pancreatitis/diagnosis ; Pancreatitis/epidemiology ; Pancreatitis/etiology ; Retrospective Studies ; Acute Disease ; COVID-19/complications ; Amylases ; Lipase
    Chemical Substances Amylases (EC 3.2.1.-) ; Lipase (EC 3.1.1.3)
    Language English
    Publishing date 2023-03-17
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1107821-2
    ISSN 1438-8359 ; 0913-8668
    ISSN (online) 1438-8359
    ISSN 0913-8668
    DOI 10.1007/s00540-023-03175-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hepatic and Pancreatic manifestations of COVID-19

    Avinash H Rajanna / Vaibhav S Bellary / Arun Udayaraj

    Asian Journal of Medical Sciences, Vol 13, Iss 6, Pp 23-

    2022  Volume 27

    Abstract: ... pancreatic enzymes and to correlate it with the severity and outcome of COVID-19 patients. Materials and ... are a known presentation, little is known about pancreatic injury as a complication of COVID-19 ... with an increased severity of the disease and also as a contributor for the greater mortality of the COVID-19 ...

    Abstract Background: Since its first detection in November 2019, the outbreak of severe acute respiratory syndrome coronavirus 2 has influenced over 200 countries, areas or territories worldwide. The virus was initially thought to be a primary respiratory pathogen, but has been reported to have multisystem involvement, including cardiovascular, neurological and gastrointestinal manifestations. The manifestations of liver damage are usually mild and generally asymptomatic. While abdominal symptoms such as pain and diarrhoea are a known presentation, little is known about pancreatic injury as a complication of COVID-19 infection. Aims and Objectives: The aim of the study was to describe the abnormality in liver enzymes and pancreatic enzymes and to correlate it with the severity and outcome of COVID-19 patients. Materials and Methods: A total of 200 patients were enrolled during the study period from August-2020 to July-2021. Data were collected from case files of patients fulfilling the inclusion criteria. Results: A cross sectional study conducted among 200 patients showed that the mean aspartate transaminase and alanine transaminase values were 41.89±50.22U/L and 37.69±41.41U/L respectively and mean amylase and lipase levels were 97.77±126.42U/L and 90.34±127.76U/L. The percentage of transaminitis that was present in patients who were discharged was 29.41% when compared to those who died which was 53.33% and this difference is statistically significant(P=0.02).However, there was no statistically significant difference observed in patients with elevated pancreatic enzymes with their outcomes. C Conclusion: Hepatic injury is more commonly associated with an increased severity of the disease and also as a contributor for the greater mortality of the COVID-19 patients.
    Keywords alt ; amylase ; ast ; lipase ; liver enzymes ; outcome ; pancreatitis ; transaminitis ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Manipal College of Medical Sciences, Pokhara
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Acute pancreatic injury induced by COVID-19.

    Patnaik, R Nikhil Kumar / Gogia, Atul / Kakar, Atul

    IDCases

    2020  Volume 22, Page(s) e00959

    Abstract: We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis ... of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled ... out. The temporal association with COVID-19 is strongly suggestive of novel coronavirus induced ...

    Abstract We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled out. The temporal association with COVID-19 is strongly suggestive of novel coronavirus induced pancreatic injury.
    Keywords covid19
    Language English
    Publishing date 2020-09-10
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2020.e00959
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: SARS-CoV2 RNA detection in a pancreatic pseudocyst sample.

    Schepis, T / Larghi, A / Papa, A / Miele, L / Panzuto, F / De Biase, L / Annibale, B / Cattani, P / Rapaccini, G L

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2020  Volume 20, Issue 5, Page(s) 1011–1012

    Abstract: ... recognized. COVID-19 associated pancreatic injury has been suggested, but its correlation ... a pancreatic pseudocyst developed as a complication of an acute edematous pancreatitis. The detection of SARS-CoV2 ... in a pancreatic pseudocyst fluid sample collected from a patient with SARS-CoV2 associated pneumonia and ...

    Abstract The involvement of gastrointestinal system in SARS-CoV2 related disease, COVID-19, is increasingly recognized. COVID-19 associated pancreatic injury has been suggested, but its correlation with pancreatic disease is still unclear. In this case report, we describe the detection of SARS-CoV2 RNA in a pancreatic pseudocyst fluid sample collected from a patient with SARS-CoV2 associated pneumonia and a pancreatic pseudocyst developed as a complication of an acute edematous pancreatitis. The detection of SARS-CoV2 within the pancreatic collection arise the question of whether this virus has a tropism for pancreatic tissue and whether it plays a role in pancreatic diseases occurrence.
    MeSH term(s) Aged ; Betacoronavirus/chemistry ; COVID-19 ; Coronavirus Infections/complications ; Female ; Humans ; Pancreatic Pseudocyst/virology ; Pancreatitis/complications ; Pandemics ; Pneumonia, Viral/complications ; RNA, Viral/analysis ; SARS-CoV-2 ; Severe Acute Respiratory Syndrome/complications ; Severe Acute Respiratory Syndrome/drug therapy ; Viral Load
    Chemical Substances RNA, Viral
    Keywords covid19
    Language English
    Publishing date 2020-05-28
    Publishing country Switzerland
    Document type Case Reports ; Letter
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2020.05.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Pancreatic Injury after COVID-19 Vaccine-A Case Report.

    Cieślewicz, Artur / Dudek, Magdalena / Krela-Kaźmierczak, Iwona / Jabłecka, Anna / Lesiak, Maciej / Korzeniowska, Katarzyna

    Vaccines

    2021  Volume 9, Issue 6

    Abstract: ... characteristics. We would like to report a case of acute pancreatic injury that occurred shortly after ... painkillers) because such symptom can be associated with acute pancreatitis. ... The COVID-19 pandemic has caused more than 3 million deaths worldwide. Recently developed ...

    Abstract The COVID-19 pandemic has caused more than 3 million deaths worldwide. Recently developed genetically engineered vaccines are the most critical solution for controlling the pandemic. Clinical trials on a large number of participants confirmed their safety and efficacy. However, with the growing number of vaccinated people, new infrequent adverse effects have been reported, not described in the medicinal product characteristics. We would like to report a case of acute pancreatic injury that occurred shortly after administering Pfizer BioNTech COVID-19 mRNA vaccine (Comirnaty). The report points out the potential need for close monitoring of patients reporting abdominal pain after vaccination (unresponsive to standard oral painkillers) because such symptom can be associated with acute pancreatitis.
    Language English
    Publishing date 2021-06-01
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines9060576
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Pathogenesis of Gastrointestinal, Hepatic, and Pancreatic Injury in Acute and Long Coronavirus Disease 2019 Infection.

    Meringer, Hadar / Wang, Andrew / Mehandru, Saurabh

    Gastroenterology clinics of North America

    2022  Volume 52, Issue 1, Page(s) 1–11

    Abstract: ... The present review examines GI involvement in patients with long coronavirus disease and discusses ... The gastrointestinal (GI) tract is targeted by severe acute respiratory syndrome coronavirus-2 ... the underlying pathophysiological mechanisms that include viral persistence, mucosal and systemic immune ...

    Abstract The gastrointestinal (GI) tract is targeted by severe acute respiratory syndrome coronavirus-2. The present review examines GI involvement in patients with long coronavirus disease and discusses the underlying pathophysiological mechanisms that include viral persistence, mucosal and systemic immune dysregulation, microbial dysbiosis, insulin resistance, and metabolic abnormalities. Due to the complex and potentially multifactorial nature of this syndrome, rigorous clinical definitions and pathophysiology-based therapeutic approaches are warranted.
    MeSH term(s) Humans ; COVID-19 ; SARS-CoV-2 ; Gastrointestinal Tract ; Liver ; Dysbiosis ; Gastrointestinal Diseases
    Language English
    Publishing date 2022-12-05
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 92114-2
    ISSN 1558-1942 ; 0889-8553
    ISSN (online) 1558-1942
    ISSN 0889-8553
    DOI 10.1016/j.gtc.2022.12.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acute pancreatic injury induced by COVID-19

    R. Nikhil Kumar Patnaik / Atul Gogia / Atul Kakar

    IDCases, Vol 22, Iss , Pp e00959- (2020)

    2020  

    Abstract: We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis ... of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled ... out. The temporal association with COVID-19 is strongly suggestive of novel coronavirus induced ...

    Abstract We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled out. The temporal association with COVID-19 is strongly suggestive of novel coronavirus induced pancreatic injury.
    Keywords Acute pancreatitis ; COVID 19 ; Infectious and parasitic diseases ; RC109-216 ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Acute pancreatic injury induced by COVID-19

    Nikhil Kumar Patnaik, R / Gogia, Atul / Kakar, Atul

    IDCases

    Abstract: We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis ... of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled ... out. The temporal association with COVID-19 is strongly suggestive of novel coronavirus induced ...

    Abstract We report a patient with COVID-19 infection presenting with acute pancreatitis. The diagnosis of pancreatitis was based on laboratory as well as radiological evidence, and all the usual etiologies were ruled out. The temporal association with COVID-19 is strongly suggestive of novel coronavirus induced pancreatic injury.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #753521
    Database COVID19

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