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Article ; Online: COVID-19 in Italy: An Analysis of Death Registry Data.

Ciminelli, Gabriele / Garcia-Mandicó, Sílvia

Journal of public health (Oxford, England)

2020 Volume 42, Issue 4, Page(s) 723–730

Abstract: ... the design of appropriate response policies.: Methods: We source daily death registry data for 4100 ... data on a host of co-factors of COVID-19 mortality, which we exploit in a differences-in-differences ... municipalities in Italy's north and match them to Census data. We augment the dataset with municipality-level ...

Abstract	Background: There are still many unknowns about COVID-19. We do not know its exact mortality rate nor the speed through which it spreads across communities. This lack of evidence complicates the design of appropriate response policies. Methods: We source daily death registry data for 4100 municipalities in Italy's north and match them to Census data. We augment the dataset with municipality-level data on a host of co-factors of COVID-19 mortality, which we exploit in a differences-in-differences regression model to analyze COVID-19-induced mortality. Results: We find that COVID-19 killed more than 0.15% of the local population during the first wave of the epidemic. We also show that official statistics vastly underreport this death toll, by about 60%. Next, we uncover the dramatic effects of the epidemic on nursing home residents in the outbreak epicenter: in municipalities with a high share of the elderly living in nursing homes, COVID-19 mortality was about twice as high as in those with no nursing home intown. Conclusions: A pro-active approach in managing the epidemic is key to reduce COVID-19 mortality. Authorities should ramp-up testing capacity and increase contact-tracing abilities. Adequate protective equipment should be provided to nursing home residents and staff.
MeSH term(s)	Age Factors ; COVID-19/mortality ; Female ; Homes for the Aged ; Humans ; Italy/epidemiology ; Male ; Nursing Homes ; Pandemics ; Registries ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Survival Analysis
Keywords	covid19
Language	English
Publishing date	2020-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	2142082-8
ISSN	1741-3850 ; 1741-3842
ISSN (online)	1741-3850
ISSN	1741-3842
DOI	10.1093/pubmed/fdaa165
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Article: COVID-19 in Italy: An Analysis of Death Registry Data

Ciminelli, Gabriele / Garcia-Mandicó, Sílvia

J. public health (Oxf)

Abstract: ... the design of appropriate response policies. METHODS: We source daily death registry data for 4100 ... data on a host of co-factors of COVID-19 mortality, which we exploit in a differences-in-differences ... municipalities in Italy's north and match them to Census data. We augment the dataset with municipality-level ...

Abstract	BACKGROUND: There are still many unknowns about COVID-19. We do not know its exact mortality rate nor the speed through which it spreads across communities. This lack of evidence complicates the design of appropriate response policies. METHODS: We source daily death registry data for 4100 municipalities in Italy's north and match them to Census data. We augment the dataset with municipality-level data on a host of co-factors of COVID-19 mortality, which we exploit in a differences-in-differences regression model to analyze COVID-19-induced mortality. RESULTS: We find that COVID-19 killed more than 0.15% of the local population during the first wave of the epidemic. We also show that official statistics vastly underreport this death toll, by about 60%. Next, we uncover the dramatic effects of the epidemic on nursing home residents in the outbreak epicenter: in municipalities with a high share of the elderly living in nursing homes, COVID-19 mortality was about twice as high as in those with no nursing home intown. CONCLUSIONS: A pro-active approach in managing the epidemic is key to reduce COVID-19 mortality. Authorities should ramp-up testing capacity and increase contact-tracing abilities. Adequate protective equipment should be provided to nursing home residents and staff.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #772654
Database	COVID19

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Article ; Online: One year of COVID-19

Laura Paneghetti / Cinzia Maria Bellettato / Annalisa Sechi / Karolina M. Stepien / Maurizio Scarpa

Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-

infection rates and symptoms in patients with inherited metabolic diseases followed by MetabERN

2022 Volume 8

Abstract: ... of the respondents reported no deaths due to COVID-19 in adult and paediatric patients with IMDs. Conclusions Most ... of patients followed by the respondents (n = 26,347), the registered prevalence of COVID-19 in the IMD ... Abstract Background Since the beginning of the COVID-19 pandemic, MetabERN has been monitoring ...

Abstract	Abstract Background Since the beginning of the COVID-19 pandemic, MetabERN has been monitoring the SARS-CoV-2 infection rates within its metabolic community. To gather data on the total number of cases and the severity of symptoms among IMD patients one year into the pandemic, an online survey was distributed among all MetabERN healthcare providers (HCP). Epidemiological analysis was performed by integrating the survey’s data with the MetabERN database. Results Survey’s respondents reported a total of 452 cases of COVID-19 among their IMD patients (213 paediatric and 239 adults). Considering the total number of patients followed by the respondents (n = 26,347), the registered prevalence of COVID-19 in the IMD population was of 1716 × 100,000. Italy emerged as the most affected country (25.4% of cases), followed by the United Kingdom (14.2% of cases). Most of the paediatric cases of COVID-19 displayed no or mild symptoms during the disease: 34% of HCP reported having asymptomatic patients in 75–100% of cases, while 37.5% reported mild symptoms in about a quarter of their patients. Similarly to paediatric cases, most adult IMD patients with COVID-19 were asymptomatic or had mild symptoms: about one third of respondents reported 75–100% asymptomatic patients and about 65% of HCP had between 0 and 50% of patients with mild symptoms. The majority of the respondents reported no deaths due to COVID-19 in adult and paediatric patients with IMDs. Conclusions Most of MetabERN’s IMD patients who got COVID-19 during the first year of the pandemic had mild symptoms and a positive outcome of the disease. However, fatal events were recorded in paediatric patients; this, together with the lack of information on the long-term effects of COVID-19 in IMDs, call for caution in the metabolic population.
Keywords	Inherited metabolic disorders ; IMDs ; COVID-19 ; SARS-CoV-2 ; Medicine ; R
Subject code	150
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Description and Analysis of Research on Death and Dying during the COVID-19 Pandemic, Published in Nursing Journals Indexed in SCOPUS.

Cuellar-Pompa, Leticia / Rodríguez-Gómez, José Ángel / Novo-Muñoz, María Mercedes / Rodríguez-Novo, Natalia / Rodríguez-Novo, Yurena M / Martínez-Alberto, Carlos-Enrique

Nursing reports (Pavia, Italy)

2024 Volume 14, Issue 2, Page(s) 655–674

Abstract: ... of death and dying during the COVID-19 pandemic in journals covering the field of nursing in the Scopus ... for these patients.: Conclusion: The results obtained offer a range of data and images that characterize ... of research. This study was retrospectively registered with the OSF Registries on the 14 March 2024. ...

Abstract	Aim: To offer an overall picture of the research published regarding the different aspects of death and dying during the COVID-19 pandemic in journals covering the field of nursing in the Scopus database. Design: bibliometric analysis. Methods: The metadata obtained were exported from Scopus for subsequent analysis through Bibliometrix. Using the VOSviewer co-word analysis function, the conceptual and thematic structure of the publications was identified. Results: A total of 119 papers were retrieved, with the participation of 527 authors. The publications were found in 71 journals covering the nursing area. The main lines of research revolved around the keywords "palliative care" and "end-of-life care" in regard to the ethical, psychological, and organizational challenges faced by the health professionals who cared for these patients. Conclusion: The results obtained offer a range of data and images that characterize the scientific production published on this topic, coming to the conclusion that, due to the multifaceted and multidisciplinary approach to the experience of death, care, and accompaniment in the dying process, bibliometric maps improve the comprehensive understanding of the semantic and conceptual structure of this field of research. This study was retrospectively registered with the OSF Registries on the 14 March 2024.
Language	English
Publishing date	2024-03-22
Publishing country	Switzerland
Document type	Journal Article
ISSN	2039-4403
ISSN (online)	2039-4403
DOI	10.3390/nursrep14020050
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Article ; Online: Gender differences in comorbidities of patients with COVID-19

Antonella Agodi / Andrea Maugeri / Giuliana Favara / Roberta Magnano San Lio / Martina Puglisi / Dario Sinatra / Giuseppe Liberti / Martina Barchitta

Heliyon, Vol 9, Iss 7, Pp e18109- (2023)

An Italian local register-based analysis

2023

Abstract: ... differences in pre-existing medical conditions of COVID-19 patients, which may influence the risk of death ... diagnosed in the province of Catania (Italy). The main aim of this analysis was to understand ... which of them posed individuals at higher risk of death.With this purpose, we analyzed data from 1424 patients ...

Abstract	In the current COVID-19 pandemic scenario, it is still necessary to understand if differences exist between genders in terms of patients’ characteristics and clinical outcomes. For this reason, we retrospectively analyzed data obtained from a local register-based dataset of all SARS-CoV-2 positive patients diagnosed in the province of Catania (Italy). The main aim of this analysis was to understand any differences between genders in the distribution of previous medical conditions, and to evaluate which of them posed individuals at higher risk of death.With this purpose, we analyzed data from 1424 patients with at least one underlying medical condition, who were tested positive for SARS-CoV-2 infection from February 2020 to December 2021. Overall, males were 59.5% of the total population and significantly younger than females (median ages: 68 years vs. 72 years; p = 0.011). The age distribution of cases by gender confirms that individuals from 70 to 79 years were the most affected in both genders. The comparison of underlying comorbidities by gender shows significant differences for diabetes (p < 0.001), other metabolic diseases (p = 0.006), and obesity (p = 0.019). Accordingly, multivariable logistic regression analysis confirmed that diabetes was more likely to be present in males than in females (p = 0.001), while other metabolic diseases and obesity were less likely to be present (p = 0.003 and p = 0.005, respectively). Although no difference in mortality was evident between genders (p = 0.141), both male and female COVID-19 patients had a significantly higher risk of death if they had comorbidities such as CVDs, kidney diseases, or chronic neurological diseases. Moreover, diabetes and chronic respiratory diseases were significant risk factors for COVID-19 mortality among men, whereas cancer was a significant contributor among women. Our findings confirm gender-differences in pre-existing medical conditions of COVID-19 patients, which may influence the risk of death. Further studies, however, are needed to ...
Keywords	Covid-19 ; SARS-CoV-2 ; Pandemic ; Gender ; Sex ; Comorbidities ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	610
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Neuropathologic findings of patients with COVID-19: a systematic review.

Pajo, Azalea T / Espiritu, Adrian I / Apor, Almira Doreen Abigail O / Jamora, Roland Dominic G

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

2021 Volume 42, Issue 4, Page(s) 1255–1266

Abstract: ... with COVID-19 in PubMed by MEDLINE, Embase, CENTRAL by the Cochrane Library, and SCOPUS from December 31 ... mechanisms by which the SARS-CoV-2 virus invades the nervous system, data on the neuropathologic findings ... The cause of death was attributed to the cardiorespiratory system (n=66, 45.2%).: Conclusions ...

Abstract	Background: Despite the expanding literature that discusses insights into the clinical picture and mechanisms by which the SARS-CoV-2 virus invades the nervous system, data on the neuropathologic findings of patients who died following SARS-CoV-2 infection is limited. Methods: A broad literature search was done for published articles that reported on histopathological findings of the brain in patients with COVID-19 in PubMed by MEDLINE, Embase, CENTRAL by the Cochrane Library, and SCOPUS from December 31, 2019 to October 31, 2020. Results: The systematic literature search strategy used resulted in a total of 1608 articles of which 14 were included in the analysis (PROSPERO registration number: CRD42020221022). There were ten case series, two case reports, one retrospective cohort, and one prospective cohort. The age of the patients ranged between 38 and 90 years old, most of them older than 65 years old (n=66, 45.2%) and males (n=79, 54.1%). Most tested negative in SARS-CoV-2 immunohistochemistry (n=70, 47.9%). The striking pathologic changes included diffuse edema (n=25, 17.1%), gliosis with diffuse activation of microglia and astrocytes (n=52, 35.6%), infarctions involving cortical and subcortical areas of the brain (n=4, 2.7%), intracranial bleed (subarachnoid hemorrhage and punctate hemorrhages) (n=18, 12.4%), arteriosclerosis (n=43, 29.5%), hypoxic-ischemic injury (n=41, 28.1%), and signs of inflammation (n=52, 35.6%). The cause of death was attributed to the cardiorespiratory system (n=66, 45.2%). Conclusions: The neuropathologic changes observed likely represent direct cytopathic effects and indirect effects secondary to host-specific inflammatory response induced by the viral infection. Further studies however are required to better elucidate the pathologic mechanism.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; COVID-19/pathology ; Female ; Humans ; Inflammation/etiology ; Inflammation/pathology ; Male ; Middle Aged ; Nervous System/pathology ; Nervous System Diseases/pathology
Language	English
Publishing date	2021-01-22
Publishing country	Italy
Document type	Journal Article ; Systematic Review
ZDB-ID	2016546-8
ISSN	1590-3478 ; 1590-1874
ISSN (online)	1590-3478
ISSN	1590-1874
DOI	10.1007/s10072-021-05068-7
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Article: Risk Factors for COVID-19: Diabetes, Hypertension, and Obesity.

Buscemi, Silvio / Corleo, Davide / Randazzo, Cristiana

Advances in experimental medicine and biology

2022 Volume 1353, Page(s) 115–129

Abstract: ... Retrospective review of literature. Analysis of epidemiological data concerning obesity prevalence and COVID-19 ... incidence, particularly in Italy and the USA.: Results: Data from several retrospective studies ... However, these data need further confirmation by studies with more accurate data registration. ...

Abstract	Introduction: The recent global pandemic of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has involved more than 7 million people worldwide and been associated with more than 400,000 deaths. No clear information is known about all the potential risk factors for COVID-19 or what factors adversely influence its clinical course and mortality. Therefore, we analyzed the role of obesity, type 2 diabetes, and hypertension as risk factors for COVID-19. Methods: We identified articles for inclusion by searching PubMed and Google Scholar (last accessed 15 June 2020). Retrospective review of literature. Analysis of epidemiological data concerning obesity prevalence and COVID-19 incidence, particularly in Italy and the USA. Results: Data from several retrospective studies of prevalence showed that patients with hypertension, type 2 diabetes, and obesity may have more severe COVID-19, intensive care unit admission, and higher mortality rates, but it is not definitively clear if this is an independent association. In general, the prevalence of obesity in patients with COVID-19 seems to be the same as that of the general population throughout the world; however, obesity seems to be associated with more severe disease and mortality in younger (< 60 years) patients. Similar effects seem to occur in patients with diabetes and/or hypertension but at older ages (> 60 years). In strict connection, it has been proposed that the use of drugs inhibiting angiotensin-converting enzyme 2 (ACE-2) or dipeptidyl dipeptidase 4 (DPP-4) might influence viral activity and disease severity since ACE-2 and DPP-4 receptors mediate SARS-CoV-2 entry into the host cells; however, no evidence exists to date that shows that this may be the case. Conclusion: Overall, diabetes, hypertension, and obesity seem to negatively affect the clinical course and disease outcome in patients with COVID-19. However, these data need further confirmation by studies with more accurate data registration.
MeSH term(s)	Aged ; COVID-19 ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/epidemiology ; Humans ; Hypertension/epidemiology ; Middle Aged ; Obesity/complications ; Obesity/epidemiology ; Retrospective Studies ; Risk Factors ; SARS-CoV-2
Language	English
Publishing date	2022-02-08
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-85113-2_7
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Article ; Online: COVID-19 in Italy

Ciminelli, Gabriele / Garcia-Mandicó, Sílvia

Journal of Public Health ; ISSN 1741-3842 1741-3850

An Analysis of Death Registry Data

2020

Abstract: ... the design of appropriate response policies. Methods We source daily death registry data for 4100 ... data on a host of co-factors of COVID-19 mortality, which we exploit in a differences-in-differences ... municipalities in Italy’s north and match them to Census data. We augment the dataset with municipality-level ...

Abstract	ABSTRACT Background There are still many unknowns about COVID-19. We do not know its exact mortality rate nor the speed through which it spreads across communities. This lack of evidence complicates the design of appropriate response policies. Methods We source daily death registry data for 4100 municipalities in Italy’s north and match them to Census data. We augment the dataset with municipality-level data on a host of co-factors of COVID-19 mortality, which we exploit in a differences-in-differences regression model to analyze COVID-19-induced mortality. Results We find that COVID-19 killed more than 0.15% of the local population during the first wave of the epidemic. We also show that official statistics vastly underreport this death toll, by about 60%. Next, we uncover the dramatic effects of the epidemic on nursing home residents in the outbreak epicenter: in municipalities with a high share of the elderly living in nursing homes, COVID-19 mortality was about twice as high as in those with no nursing home intown. Conclusions A pro-active approach in managing the epidemic is key to reduce COVID-19 mortality. Authorities should ramp-up testing capacity and increase contact-tracing abilities. Adequate protective equipment should be provided to nursing home residents and staff.
Keywords	Public Health, Environmental and Occupational Health ; General Medicine ; covid19
Language	English
Publisher	Oxford University Press (OUP)
Publishing country	uk
Document type	Article ; Online
DOI	10.1093/pubmed/fdaa165
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Article ; Online: Coronavirus (COVID-19) in Italy

Alessandra Putrino / Mario Raso / Cosimo Magazzino / Gabriella Galluccio

BMC Oral Health, Vol 20, Iss 1, Pp 1-

knowledge, management of patients and clinical experience of Italian dentists during the spread of contagion

2020 Volume 15

Abstract: ... has now spread globally. Italy registered its first case in the second half of February, and ... contact with aerosols with high bacterial and viral potential. Therefore, during this COVID-19 emergency ... further spread of infection. Methods Following the data published in the international literature as well ...

Abstract	Abstract Background The coronavirus infection that emerged in China in the last few months of 2019 has now spread globally. Italy registered its first case in the second half of February, and in a short time period, it became the top country in Europe in terms of the number of infected people and the first in the world in terms of deaths. The medical and scientific community has been called upon to manage the emergency and to take measures. Dentists also need to take new precautions during their clinical activity to protect themselves, coworkers and patients from the risks of contagion and to avoid further spread of infection. Methods Following the data published in the international literature as well as the guidelines and directives constantly updated by the WHO and by the national health authorities, a questionnaire to be completed anonymously was submitted online to Italian dentists using social tools and online professional platforms. The collected data were processed statistically, providing descriptive data and analysis of correlations of the most significant parameters using the Pearson’s χ2, the Likelihood-Ratio χ2, Cramér’s V, Fisher’s exact test, Goodman and Kruskal’s γ, and Kendall’s τb (p < 0.05). Results A total of 535 dentists from Italy participated in the survey. A good level of scientific knowledge about coronavirus and the extra precautionary measures needed to limit the spread was related to the age of respondents and their sex. Coming from areas with higher concentrations of cases affected knowledge, level of attention and perception of risk related to dental activity. Conclusions At the moment, there are no therapies or vaccines to contain the infection with the new coronavirus that is causing many infections, many of which are fatal, worldwide. Dentists are one of the categories at highest risk of encountering diseases and infections because they work in close proximity with patients, and in their procedures, there is always contact with aerosols with high bacterial and viral potential. Therefore, during this COVID-19 emergency, it is important that dentists are properly informed and take the appropriate precautionary measures.
Keywords	2019 novel coronavirus ; COVID-19 ; Dentistry ; Health management ; Knowledge ; Survey ; RK1-715 ; covid19
Subject code	300
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Coronavirus (COVID-19) in Italy

Putrino, Alessandra / Raso, Mario / Magazzino, Cosimo / Galluccio, Gabriella

knowledge, management of patients and clinical experience of Italian dentists during the spread of contagion

2020

Abstract: ... spread globally. Italy registered its first case in the second half of February, and in a short time ... contact with aerosols with high bacterial and viral potential. Therefore, during this COVID-19 emergency ... of infection. Methods: Following the data published in the international literature as well as the guidelines ...

Abstract	Background: The coronavirus infection that emerged in China in the last few months of 2019 has now spread globally. Italy registered its first case in the second half of February, and in a short time period, it became the top country in Europe in terms of the number of infected people and the first in the world in terms of deaths. The medical and scientific community has been called upon to manage the emergency and to take measures. Dentists also need to take new precautions during their clinical activity to protect themselves, coworkers and patients from the risks of contagion and to avoid further spread of infection. Methods: Following the data published in the international literature as well as the guidelines and directives constantly updated by the WHO and by the national health authorities, a questionnaire to be completed anonymously was submitted online to Italian dentists using social tools and online professional platforms. The collected data were processed statistically, providing descriptive data and analysis of correlations of the most significant parameters using the Pearson's χ2, the Likelihood-Ratio χ2, Cramér's V, Fisher's exact test, Goodman and Kruskal's γ, and Kendall's τb (p < 0.05). Results: A total of 535 dentists from Italy participated in the survey. A good level of scientific knowledge about coronavirus and the extra precautionary measures needed to limit the spread was related to the age of respondents and their sex. Coming from areas with higher concentrations of cases affected knowledge, level of attention and perception of risk related to dental activity. Conclusions: At the moment, there are no therapies or vaccines to contain the infection with the new coronavirus that is causing many infections, many of which are fatal, worldwide. Dentists are one of the categories at highest risk of encountering diseases and infections because they work in close proximity with patients, and in their procedures, there is always contact with aerosols with high bacterial and viral potential. Therefore, during this COVID-19 emergency, it is important that dentists are properly informed and take the appropriate precautionary measures. © 2020 The Author(s).
Keywords	2019 novel coronavirus ; COVID-19 ; dentistry ; health management ; knowledge ; survey ; covid19
Subject code	300
Language	English
Publisher	BMC
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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