Article ; Online: Baricitinib as rescue therapy in a patient with COVID-19 with no complete response to sarilumab.
2020 Volume 48, Issue 5, Page(s) 767–771
Abstract: A patient with COVID-19-related severe respiratory failure, with insufficient response ... to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt ... resolution of the respiratory function and improvement in the radiological picture after baricitinib ...
| Abstract | A patient with COVID-19-related severe respiratory failure, with insufficient response to an antiretroviral therapy, hydroxychloroquine and Interleukin-6 (IL-6) antagonist therapy, presented a prompt resolution of the respiratory function and improvement in the radiological picture after baricitinib at an oral dose of 4 mg per day for 2 weeks. |
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| MeSH term(s) | Acute Disease ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antiviral Agents/therapeutic use ; Azetidines/therapeutic use ; Azithromycin/therapeutic use ; Betacoronavirus/drug effects ; Betacoronavirus/pathogenicity ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/physiopathology ; Coronavirus Infections/virology ; Drug Combinations ; Drug Repositioning ; Humans ; Hydroxychloroquine/therapeutic use ; Lopinavir/therapeutic use ; Male ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/virology ; Purines ; Pyrazoles ; Respiratory Insufficiency/drug therapy ; Respiratory Insufficiency/physiopathology ; Respiratory Insufficiency/virology ; Ritonavir/therapeutic use ; SARS-CoV-2 ; Sulfonamides/therapeutic use ; Treatment Outcome |
| Chemical Substances | Antibodies, Monoclonal, Humanized ; Antiviral Agents ; Azetidines ; Drug Combinations ; Purines ; Pyrazoles ; Sulfonamides ; lopinavir-ritonavir drug combination ; Lopinavir (2494G1JF75) ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; baricitinib (ISP4442I3Y) ; sarilumab (NU90V55F8I) ; Ritonavir (O3J8G9O825) |
| Keywords | covid19 |
| Language | English |
| Publishing date | 2020-07-08 |
| Publishing country | Germany |
| Document type | Case Reports ; Journal Article |
| ZDB-ID | 185104-4 |
| ISSN | 1439-0973 ; 0300-8126 ; 0173-2129 |
| ISSN (online) | 1439-0973 |
| ISSN | 0300-8126 ; 0173-2129 |
| DOI | 10.1007/s15010-020-01476-7 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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