Article: Clinical description of the broad range of neurological presentations of COVID-19: A retrospective case series.
2021 Volume 177, Issue 3, Page(s) 275–282
Abstract: ... 19.: Methods: In this monocentric retrospective case series, medical records from patients ... can yield a broad spectrum of neurological disorders. Because neurological presentations of COVID-19 often ... challenge because they encompass a broad neurological spectrum and may occur before the diagnosis of COVID ...
| Abstract | Background: Neurological disorders associated with SARS-CoV-2 infection represent a clinical challenge because they encompass a broad neurological spectrum and may occur before the diagnosis of COVID-19. Methods: In this monocentric retrospective case series, medical records from patients with acute neurological disorders associated with SARS-CoV-2 infection from medicine departments of an academic center in Paris area were collected between March 15 Results: Twenty-six patients diagnosed with SARS-CoV-2 infection presented with neurological disorders: encephalitis (N=8), encephalopathy (N=6), cerebrovascular events (ischemic strokes N=4 and vein thromboses N=2), other central nervous system (CNS) disorders (N=4), and Guillain-Barré syndrome (N=2). The diagnosis of SARS-CoV-2 was delayed on average 1.6 days after the onset of neurological disorder, especially in case of encephalitis 3.9 days, encephalopathy 1.0 day, and cerebrovascular event 2.7 days. Conclusions: Our study confirms that COVID-19 can yield a broad spectrum of neurological disorders. Because neurological presentations of COVID-19 often occur a few days before the diagnosis of SARS-COV-2 infection, clinicians should take preventive measures such as patient isolation and masks for any new admission to avoid nosocomial infections. Anti-SARS-CoV2 antibody detection in RT-PCR SARS CoV-2 negative suspected cases is useful to confirm a posteriori the diagnosis of atypical COVID-19 presentations. |
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| MeSH term(s) | Adolescent ; Adult ; Aged ; Aged, 80 and over ; COVID-19/complications ; COVID-19/epidemiology ; COVID-19/psychology ; Female ; Humans ; Male ; Middle Aged ; Nervous System Diseases/epidemiology ; Nervous System Diseases/etiology ; Nervous System Diseases/virology ; Paris/epidemiology ; Retrospective Studies ; SARS-CoV-2/physiology ; Young Adult | |||||
| Language | English | |||||
| Publishing date | 2021-02-11 | |||||
| Publishing country | France | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 4593-7 | |||||
| ISSN | 2213-0004 ; 0035-3787 | |||||
| ISSN (online) | 2213-0004 | |||||
| ISSN | 0035-3787 | |||||
| DOI | 10.1016/j.neurol.2021.01.004 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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