Article: Eomesodermin and T-bet mark developmentally distinct human natural killer cells.
JCI insight
2017 Volume 2, Issue 5, Page(s) e90063
Abstract: Immaturity of the immune system of human fetuses and neonates is often invoked to explain ... life remains incompletely explored. We now show that the most mature NK cells found in adult (or ... postnatal) human circulation (CD94 ...
| Abstract | Immaturity of the immune system of human fetuses and neonates is often invoked to explain their increased susceptibility to infection; however, the development of the fetal innate immune system in early life remains incompletely explored. We now show that the most mature NK cells found in adult (or postnatal) human circulation (CD94 |
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| MeSH term(s) | Adult ; Animals ; Antigens, CD/immunology ; Cell Differentiation ; Disease Susceptibility/immunology ; Fetus/metabolism ; Humans ; Infant ; Infant, Newborn ; Killer Cells, Natural/cytology ; Killer Cells, Natural/metabolism ; Mice ; T-Box Domain Proteins/metabolism |
| Chemical Substances | Antigens, CD ; EOMES protein, human ; T-Box Domain Proteins ; T-box transcription factor TBX21 |
| Language | English |
| Publishing date | 2017-03-09 |
| Publishing country | United States |
| Document type | Journal Article ; Research Support, N.I.H., Extramural |
| ISSN | 2379-3708 |
| ISSN | 2379-3708 |
| DOI | 10.1172/jci.insight.90063 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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