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Article ; Online: COVID-19: What Should Clinicians and Scientists Do and When?

Corley, Douglas A / Peek, Richard M

2020 Volume 158, Issue 8, Page(s) 2020–2023

MeSH term(s)	Betacoronavirus/pathogenicity ; Biomedical Research ; COVID-19 ; Communicable Disease Control/methods ; Communicable Disease Control/organization & administration ; Congresses as Topic ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/prevention & control ; Coronavirus Infections/transmission ; Global Burden of Disease ; Health Personnel/organization & administration ; Humans ; Mass Screening/methods ; Mass Screening/organization & administration ; Pandemics/prevention & control ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/transmission ; Research Personnel/organization & administration ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-03-19
Publishing country	United States
Document type	Editorial
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2020.03.026
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Article: COVID-19: What Should Clinicians and Scientists Do and When?

Corley, Douglas A / Peek, Richard M

Gastroenterology

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #32439274
Database	COVID19

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Article ; Online: COVID-19: Guidance for What Clinicians and Scientists Should Do and When.

Corley, Douglas A / Peek, Richard M

Gastroenterology

2021 Volume 160, Issue 6, Page(s) 1922–1923

MeSH term(s)	COVID-19/epidemiology ; Gastroenterology ; Humans ; Physicians ; Practice Guidelines as Topic ; SARS-CoV-2
Language	English
Publishing date	2021-05-01
Publishing country	United States
Document type	Editorial
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2021.04.011
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Article ; Online: Science's Response to CoVID-19.

Long, Marcus J C / Aye, Yimon

ChemMedChem

2021 Volume 16, Issue 15, Page(s) 2288–2314

Abstract: ... which we do not discuss herein, the response of scientists and clinicians to this complex problem has ... reflected the need to detect CoVID-19 rapidly, to diagnose patients likely to show adverse symptoms, and ... to treat severe and critical CoVID-19. Here we aim to encapsulate these varied and sometimes conflicting ...

Abstract	CoVID-19 is a multi-symptomatic disease which has made a global impact due to its ability to spread rapidly, and its relatively high mortality rate. Beyond the heroic efforts to develop vaccines, which we do not discuss herein, the response of scientists and clinicians to this complex problem has reflected the need to detect CoVID-19 rapidly, to diagnose patients likely to show adverse symptoms, and to treat severe and critical CoVID-19. Here we aim to encapsulate these varied and sometimes conflicting approaches and the resulting data in terms of chemistry and biology. In the process we highlight emerging concepts, and potential future applications that may arise out of this immense effort.
MeSH term(s)	Antiviral Agents/therapeutic use ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19 Serological Testing ; Drug Repositioning ; Humans ; Intersectoral Collaboration ; Pandemics ; SARS-CoV-2/drug effects ; SARS-CoV-2/genetics ; SARS-CoV-2/physiology ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents
Language	English
Publishing date	2021-06-22
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202100079
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Severe pediatric COVID-19: a review from the clinical and immunopathophysiological perspectives.

Sun, Yi-Kan / Wang, Can / Lin, Pei-Quan / Hu, Lei / Ye, Jing / Gao, Zhi-Gang / Lin, Ru / Li, Hao-Min / Shu, Qiang / Huang, Li-Su / Tan, Lin-Hua

World journal of pediatrics : WJP

2024 Volume 20, Issue 4, Page(s) 307–324

Abstract: ... mediated condition chronologically associated with COVID-19 exposure, denotes another scientific and ... the PubMed, Embase, and Wanfang databases. Searched keywords included "COVID-19 in children", "severe ... pediatric COVID-19", and "critical illness in children with COVID-19".: Results: Risks of developing ...

Abstract	Background: Coronavirus disease 2019 (COVID-19) tends to have mild presentations in children. However, severe and critical cases do arise in the pediatric population with debilitating systemic impacts and can be fatal at times, meriting further attention from clinicians. Meanwhile, the intricate interactions between the pathogen virulence factors and host defense mechanisms are believed to play indispensable roles in severe COVID-19 pathophysiology but remain incompletely understood. Data sources: A comprehensive literature review was conducted for pertinent publications by reviewers independently using the PubMed, Embase, and Wanfang databases. Searched keywords included "COVID-19 in children", "severe pediatric COVID-19", and "critical illness in children with COVID-19". Results: Risks of developing severe COVID-19 in children escalate with increasing numbers of co-morbidities and an unvaccinated status. Acute respiratory distress stress and necrotizing pneumonia are prominent pulmonary manifestations, while various forms of cardiovascular and neurological involvement may also be seen. Multiple immunological processes are implicated in the host response to COVID-19 including the type I interferon and inflammasome pathways, whose dysregulation in severe and critical diseases translates into adverse clinical manifestations. Multisystem inflammatory syndrome in children (MIS-C), a potentially life-threatening immune-mediated condition chronologically associated with COVID-19 exposure, denotes another scientific and clinical conundrum that exemplifies the complexity of pediatric immunity. Despite the considerable dissimilarities between the pediatric and adult immune systems, clinical trials dedicated to children are lacking and current management recommendations are largely adapted from adult guidelines. Conclusions: Severe pediatric COVID-19 can affect multiple organ systems. The dysregulated immune pathways in severe COVID-19 shape the disease course, epitomize the vast functional diversity of the pediatric immune system and highlight the immunophenotypical differences between children and adults. Consequently, further research may be warranted to adequately address them in pediatric-specific clinical practice guidelines.
MeSH term(s)	Humans ; COVID-19/immunology ; COVID-19/complications ; Child ; Systemic Inflammatory Response Syndrome/immunology ; Systemic Inflammatory Response Syndrome/physiopathology ; Severity of Illness Index
Language	English
Publishing date	2024-02-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-023-00790-y
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Article ; Online: COVID-19

Corley, Douglas A. / Peek, Richard M.

Gastroenterology

What Should Clinicians and Scientists Do and When?

2020 Volume 158, Issue 8, Page(s) 2020–2023

Keywords	Gastroenterology ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2020.03.026
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Physical performance testing in post-COVID-19 patients

Vanessa R Resqueti / Elena Gimeno-Santos / Rodrigo Torres-Castro / J Vilaró / Guilherme AF Fregonezi / Larissa Fernanda Estevam do Nascimento / Luciana Andrade Mendes

BMJ Open, Vol 13, Iss

protocol for a systematic review of psychometric measurement properties

2023 Volume 4

Abstract: ... post-COVID-19 patients (aged 18 years or older and with a confirmed diagnosis of COVID-19 ... Introduction COVID-19 is an infectious disease that causes severe acute respiratory syndrome ... A large variety of exercise capacity tests are used for the evaluation of post-COVID-19 patients ...

Abstract	Introduction COVID-19 is an infectious disease that causes severe acute respiratory syndrome. A large variety of exercise capacity tests are used for the evaluation of post-COVID-19 patients, but the psychometric properties of these exercise tests remain undetermined in this population. This study aims to critically appraise, compare and summarise the psychometric properties (validity, reliability and responsiveness) of all physical performance tests that are used to assess exercise capacity in post-COVID-19 patients.Methods and analysis This systematic review protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols guidelines. We will include studies with hospitalised adult post-COVID-19 patients (aged 18 years or older and with a confirmed diagnosis of COVID-19). The research will cover randomised controlled trials (RCTs), quasi-RCTs and observational studies published in English and performed in the following settings: hospital, rehabilitation centre, outpatient clinic. We will search the following databases with no date restrictions: PubMed/MEDLINE, EMBASE, SciELO, Cochrane Library, CINAHL and Web of Science. Two authors will independently assess the risk of bias (using the Consensus-Based Standards for the Selection of Health Measurement Instruments Risk of bias checklist) and the certainty of evidence (using the Grading of Recommendations, Assessment, Development and Evaluations). According to the results obtained, data will be meta-analysed or reported narratively.Ethics and dissemination No ethical approval is required for this publication since it will be based on published data. Results of this review will be disseminated via peer-reviewed publications and conference presentations.PROSPERO registration number CRD42021242334.
Keywords	Medicine ; R
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	BMJ Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings ; Online: Covid-on-the-Web

Michel, Franck / Gandon, Fabien / Ah-Kane, Valentin / Bobasheva, Anna / Cabrio, Elena / Corby, Olivier / Gazzotti, Raphaël / Giboin, Alain / Marro, Santiago / Mayer, Tobias / Simon, Mathieu / Villata, Serena / Winckler, Marco

International Semantic Web Conference (ISWC) ; https://hal.archives-ouvertes.fr/hal-02939363 ; International Semantic Web Conference (ISWC), Nov 2020, Athens, Greece

Knowledge Graph and Services to Advance COVID-19 Research

2020

Abstract: ... biomedical researchers to access, query and make sense of COVID-19 related literature. To do so, it adapts ... combines and extends tools to process, analyze and enrich the "COVID-19 Open Research Dataset" (CORD-19 ... International audience ...

Abstract	International audience Scientists are harnessing their multidisciplinary expertise and resources to fight the COVID-19 pandemic. Aligned with this mind-set, the Covid-on-the-Web project aims to allow biomedical researchers to access, query and make sense of COVID-19 related literature. To do so, it adapts, combines and extends tools to process, analyze and enrich the "COVID-19 Open Research Dataset" (CORD-19) that gathers 50,000+ full-text scientific articles related to the coronaviruses. We report on the RDF dataset and software resources produced in this project by leveraging skills in knowledge representation, text, data and argument mining, as well as data visualization and exploration. The dataset comprises two main knowledge graphs describing (1) named entities mentioned in the CORD-19 corpus and linked to DBpedia, Wikidata and other BioPortal vocabularies, and (2) arguments extracted using ACTA, a tool automating the extraction and visualization of argumentative graphs, meant to help clinicians analyze clinical trials and make decisions. On top of this dataset, we provide several visualization and exploration tools based on the Corese Semantic Web platform, MGExplorer visualization library, as well as the Jupyter Notebook technology. All along this initiative, we have been engaged in discussions with healthcare and medical research institutes to align our approach with the actual needs of the biomedical community, and we have paid particular attention to comply with the open and reproducible science goals, and the FAIR principles.
Keywords	COVID-19 ; arguments ; visualization ; named entities ; linked data ; [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ; covid19
Subject code	306
Language	English
Publishing date	2020-11-02
Publisher	HAL CCSD
Publishing country	fr
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings ; Online: Covid-on-the-Web

International Semantic Web Conference (ISWC) ; https://hal.archives-ouvertes.fr/hal-02939363 ; International Semantic Web Conference (ISWC), Nov 2020, Athens, Greece. ⟨10.1007/978-3-030-62466-8_19⟩

Knowledge Graph and Services to Advance COVID-19 Research

2020

Abstract	International audience Scientists are harnessing their multidisciplinary expertise and resources to fight the COVID-19 pandemic. Aligned with this mind-set, the Covid-on-the-Web project aims to allow biomedical researchers to access, query and make sense of COVID-19 related literature. To do so, it adapts, combines and extends tools to process, analyze and enrich the "COVID-19 Open Research Dataset" (CORD-19) that gathers 50,000+ full-text scientific articles related to the coronaviruses. We report on the RDF dataset and software resources produced in this project by leveraging skills in knowledge representation, text, data and argument mining, as well as data visualization and exploration. The dataset comprises two main knowledge graphs describing (1) named entities mentioned in the CORD-19 corpus and linked to DBpedia, Wikidata and other BioPortal vocabularies, and (2) arguments extracted using ACTA, a tool automating the extraction and visualization of argumentative graphs, meant to help clinicians analyze clinical trials and make decisions. On top of this dataset, we provide several visualization and exploration tools based on the Corese Semantic Web platform, MGExplorer visualization library, as well as the Jupyter Notebook technology. All along this initiative, we have been engaged in discussions with healthcare and medical research institutes to align our approach with the actual needs of the biomedical community, and we have paid particular attention to comply with the open and reproducible science goals, and the FAIR principles.
Keywords	COVID-19 ; arguments ; visualization ; named entities ; linked data ; [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ; covid19
Subject code	306
Language	English
Publishing date	2020-11-02
Publisher	HAL CCSD
Publishing country	fr
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Conference proceedings ; Online: Covid-on-the-Web

Knowledge Graph and Services to Advance COVID-19 Research

2020

Abstract	International audience Scientists are harnessing their multidisciplinary expertise and resources to fight the COVID-19 pandemic. Aligned with this mind-set, the Covid-on-the-Web project aims to allow biomedical researchers to access, query and make sense of COVID-19 related literature. To do so, it adapts, combines and extends tools to process, analyze and enrich the "COVID-19 Open Research Dataset" (CORD-19) that gathers 50,000+ full-text scientific articles related to the coronaviruses. We report on the RDF dataset and software resources produced in this project by leveraging skills in knowledge representation, text, data and argument mining, as well as data visualization and exploration. The dataset comprises two main knowledge graphs describing (1) named entities mentioned in the CORD-19 corpus and linked to DBpedia, Wikidata and other BioPortal vocabularies, and (2) arguments extracted using ACTA, a tool automating the extraction and visualization of argumentative graphs, meant to help clinicians analyze clinical trials and make decisions. On top of this dataset, we provide several visualization and exploration tools based on the Corese Semantic Web platform, MGExplorer visualization library, as well as the Jupyter Notebook technology. All along this initiative, we have been engaged in discussions with healthcare and medical research institutes to align our approach with the actual needs of the biomedical community, and we have paid particular attention to comply with the open and reproducible science goals, and the FAIR principles.
Keywords	COVID-19 ; arguments ; visualization ; named entities ; linked data ; [INFO.INFO-AI]Computer Science [cs]/Artificial Intelligence [cs.AI] ; covid19
Subject code	306
Language	English
Publishing date	2020-11-02
Publisher	HAL CCSD
Publishing country	fr
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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