Article ; Online: Effects of Simulated COVID-19 Cytokine Storm on Stent Thrombogenicity.
Cardiovascular revascularization medicine : including molecular interventions
2021 Volume 35, Page(s) 129–138
Abstract: ... simulated cytokine storm conditions, fluoropolymer-coated stents showed the most favorable anti-thrombogenic ... Background: Cytokine storm-related hypercoagulation may be important in the pathogenesis of stent ... supplemented with 400 pg/mL IL-6 and 100 pg/mL TNF-α, similar to what is seen in cytokine storm caused by SARS ...
| Abstract | Background: Cytokine storm-related hypercoagulation may be important in the pathogenesis of stent thrombosis in patients with SARS-CoV-2. Whether stent polymers behave differently under such conditions has never been explored. Methods: Fluorinated polymer-nanocoated and uncoated COBRA stents (CeloNova), BioLinx-polymer-coated Resolute Onyx stents (Medtronic), and Synergy stents (Boston Scientific), which are abluminally coated with a bioabsorbable polymer, were exposed to human blood from healthy donors which was supplemented with 400 pg/mL IL-6 and 100 pg/mL TNF-α, similar to what is seen in cytokine storm caused by SARS-CoV-2. Platelet adhesion and neutrophil activation, assessed by immunofluorescence, were compared under cytokine storm and control conditions (untreated blood) (n = 4 experimental runs). Results: Platelet adhesion values, defined as %platelet-covered area x staining intensity, were significantly lower in coated and uncoated COBRA and in Resolute Onyx than in Synergy under control conditions (1.28 × 10 Conclusions: Blood-biomaterials interactions may determine the thrombogenic potential of stents. Under simulated cytokine storm conditions, fluoropolymer-coated stents showed the most favorable anti-thrombogenic and anti-inflammatory properties. |
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| MeSH term(s) | COVID-19 ; Cytokine Release Syndrome ; Humans ; Prosthesis Design ; SARS-CoV-2 ; Stents | |||||
| Language | English | |||||
| Publishing date | 2021-04-08 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2212113-4 | |||||
| ISSN | 1878-0938 ; 1553-8389 | |||||
| ISSN (online) | 1878-0938 | |||||
| ISSN | 1553-8389 | |||||
| DOI | 10.1016/j.carrev.2021.03.023 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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