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  1. Article: Wegener Granulomatosis: Otologic Manifestation as First Symptom.

    Costa, Carla Fabiane da / Polanski, Jose Fernando

    International archives of otorhinolaryngology

    2014  Volume 19, Issue 3, Page(s) 266–268

    Abstract: Introduction Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized ... treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses ... with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations ...

    Abstract Introduction Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys. Objective To describe a case of Wegener disease with atypical manifestation. Resumed Report We describe the case of a 50-year-old woman with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations. Conclusion In cases of acute ear manifestations with or without hearing loss and with poor response to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses and treatment of this rare disease, there was favorable evolution.
    Language English
    Publishing date 2014-11-11
    Publishing country Brazil
    Document type Case Reports
    ZDB-ID 2578584-9
    ISSN 1809-4864 ; 1809-9777
    ISSN (online) 1809-4864
    ISSN 1809-9777
    DOI 10.1055/s-0034-1387164
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Wegener Granulomatosis: Otologic Manifestation as First Symptom

    Costa, Carla Fabiane da / Polanski, Jose Fernando

    International Archives of Otorhinolaryngology

    2014  Volume 19, Issue 03, Page(s) 266–268

    Abstract: Introduction: Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized ... to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After ... with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations ...

    Abstract Introduction: Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys.
    Objective: To describe a case of Wegener disease with atypical manifestation.
    Resumed Report: We describe the case of a 50-year-old woman with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations.
    Conclusion: In cases of acute ear manifestations with or without hearing loss and with poor response to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses and treatment of this rare disease, there was favorable evolution.
    Keywords Wegener granulomatosis ; otitis media ; hearing loss
    Language English
    Publishing date 2014-11-11
    Publisher Thieme Publicações Ltda
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2578584-9
    ISSN 1809-4864 ; 1809-9777
    ISSN (online) 1809-4864
    ISSN 1809-9777
    DOI 10.1055/s-0034-1387164
    Database Thieme publisher's database

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  3. Article ; Online: Wegener Granulomatosis

    Carla Fabiane da Costa / Jose Fernando Polanski

    International Archives of Otorhinolaryngology, Vol 19, Iss 03, Pp 266-

    Otologic Manifestation as First Symptom

    2015  Volume 268

    Abstract: ... of Wegener disease with atypical manifestation. Resumed Report We describe the case of a 50-year-old woman ... Abstract Introduction Wegener granulomatosis is a systemic vasculitis affecting small and medium ... treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses ...

    Abstract Abstract Introduction Wegener granulomatosis is a systemic vasculitis affecting small and medium-sized vessels of the upper and lower respiratory tract and kidneys. Objective To describe a case of Wegener disease with atypical manifestation. Resumed Report We describe the case of a 50-year-old woman with chronic otitis media and sensorineural hearing loss as the primary symptoms, without other manifestations. Conclusion In cases of acute ear manifestations with or without hearing loss and with poor response to usual treatments, Wegener granulomatosis should be included among the possible etiologies. After adequate diagnoses and treatment of this rare disease, there was favorable evolution.
    Keywords wegener granulomatosis ; otitis media ; hearing loss ; Medicine ; R ; Otorhinolaryngology ; RF1-547
    Language English
    Publishing date 2015-07-01T00:00:00Z
    Publisher Thieme Revinter Publicações Ltda.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Manifestaciones otorrinolaringológicas de la granulomatosis de Wegener.

    Vega Braga, Fabio Luis / Machado de Carvalho, Guilherme / Caixeta Guimarães, Alexandre / Scaramussa, Lutiane / Jordão Gusmão, Reinaldo

    Acta otorrinolaringologica espanola

    2013  Volume 64, Issue 1, Page(s) 45–49

    Abstract: ... can often occur as the first and only manifestation. The aim of this study was to determine the frequency ... of the airway and glomerulonephritis. Since its first description, important advances have occurred in diagnosis ... role in diagnosis, treatment and follow-up of these patients. Knowing common symptoms makes diagnosis ...

    Title translation Otolaryngological manifestations of Wegener's disease.
    Abstract Introduction: Wegener's granulomatosis (WG) is characterised by granulomatous vasculitis of the airway and glomerulonephritis. Since its first description, important advances have occurred in diagnosis and treatment; however, the aetiology remains unknown. Involvement of the head and neck region can often occur as the first and only manifestation. The aim of this study was to determine the frequency of symptoms and signs in the region of the nose, ears and pharynx-larynx in a group of patients with WG.
    Materials and methods: We evaluated 17 patients with WG defined by clinical, laboratory and pathology criteria. Detailed histories were taken and an ENT physical examination, audiometry, tympanometry and nasofibrolaryngoscopy were performed in all patients.
    Results: The average age was 41.7 years and the average disease time was 9.12 years, ranging between 1 and 40. In these patients, 9 (53.1%) reported hearing loss and had altered audiometry, and 5 (55.6%) had bilateral sensorineural hearing loss. In the nose, nasal obstruction in 11 (64.8%) and rhinorrhoea in 10 (58.8%) were the most prevalent; there was altered endoscopy in 12 (70.2%). In the pharynx-larynx, dyspnoea in 6 (35%) and hoarseness in 7 (41.2%) were the most prevalent and 7 (41%) had an altered laryngoscopy.
    Conclusion: The otolaryngologist plays an essential role in diagnosis, treatment and follow-up of these patients. Knowing common symptoms makes diagnosis and treatment easier and earlier.
    MeSH term(s) Adult ; Aged ; Granulomatosis with Polyangiitis/complications ; Humans ; Middle Aged ; Otorhinolaryngologic Diseases/diagnosis ; Otorhinolaryngologic Diseases/etiology ; Prospective Studies ; Young Adult
    Language Spanish
    Publishing date 2013-01
    Publishing country Spain
    Document type English Abstract ; Journal Article
    ZDB-ID 730022-0
    ISSN 1988-3013 ; 0001-6519
    ISSN (online) 1988-3013
    ISSN 0001-6519
    DOI 10.1016/j.otorri.2012.07.003
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  5. Article ; Online: Otologic symptoms as initial manifestation of wegener granulomatosis: diagnostic dilemma.

    Wierzbicka, Małgorzata / Szyfter, Witold / Puszczewicz, Mariusz / Borucki, Lukasz / Bartochowska, Anna

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2011  Volume 32, Issue 6, Page(s) 996–1000

    Abstract: Objective: To show 7 cases of Wegener granulomatosis (WG) with early aural symptoms and to discuss ... symptoms as initial manifestation of WG diagnostic dilemma.: Results: The authors want to underline ... under control for 1 to 5 years.: Conclusion: As WG often presents otologic symptoms, as an initial ...

    Abstract Objective: To show 7 cases of Wegener granulomatosis (WG) with early aural symptoms and to discuss the problems of otologic manifestation in WG.
    Study design: Retrospective case review.
    Setting: : Tertiary care university hospital.
    Patients: All patients were administered to the ENT University Department in Poznań in years 2002-2008 because of otitis media with effusion, facial palsy, sensorineural profound hypoacusis, hypoacusis combined with purulent discharge, and facial nerve palsy or progression of mixed type hypoacusis.
    Interventions: Diagnostics and treatment. MAIN OUTCOME MEASURESL: Otologic symptoms as initial manifestation of WG diagnostic dilemma.
    Results: The authors want to underline the young age of the patients, ranging from 32 to 46 years. The outcome of initially otologic cases, which developed generalized form of WG, was poor (the first patient died after 2 months, the second patient died after 7 days, the third had the pulmonary insufficiency in 2 months of observation, and the fourth had severe renal failure in 1 month), whereas the patients with localized disease have been successfully under control for 1 to 5 years.
    Conclusion: As WG often presents otologic symptoms, as an initial sign in some cases, it is important to take WG into consideration in atypical inflammatory states of the ear. The otologic onset of WG is very insidious, and prompt diagnosis in early stage of disease is a challenge. Focal and localized disease in the aural region might possibly require less aggressive therapy than acute-onset multi-organ disease and is connected with better prognosis.
    MeSH term(s) Adult ; Female ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Hearing Loss, Sensorineural/etiology ; Humans ; Male ; Middle Aged ; Otitis Media with Effusion/etiology ; Retrospective Studies
    Language English
    Publishing date 2011-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0b013e31822558fd
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    In stock of ZB MED Cologne/Königswinter

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  6. Article ; Online: Objawy otologiczne w świetle najnowszej wiedzy o ziarniniaku Wegenera.

    Wierzbicka, Małgorzata / Puszczewicz, Mariusz / Bartochowska, Anna / Szyfter, Witold

    Otolaryngologia polska = The Polish otolaryngology

    2012  Volume 66, Issue 4, Page(s) 254–258

    Abstract: Objective: Wegener granulomatosis (WG) presents nasal, laryngeal and otologic symptoms ... The outcome of initially otologic cases, which developed generalized form of WG was poor (first died after 2 ... the problems of otologic manifestation in WG and present the newest concepts of diagnostics and treatment ...

    Title translation The otologic manifestation of Wegener's granulomatosis--review of contemporary achievements in diagnostics and treatment.
    Abstract Objective: Wegener granulomatosis (WG) presents nasal, laryngeal and otologic symptoms as an initial signs of the disease and finally can affect the ENT region in 3/4 patients. The authors want to analyze 7 cases of WG with early aural symptoms, connected with the diagnostics dilemma, discuss the problems of otologic manifestation in WG and present the newest concepts of diagnostics and treatment of this condition.
    Material and methods: All patients were treated in the ENT University Department in Poznań in the years 2002-2010. Three patients manifested isolated aural symptoms at the time of the initial clinical presentation (otitis media with effusion, facial palsy and sensorineural profound hypoacusis), whereas in four aural problems were the first, the most expressed and pronounced. In the last four cases neither the initial stage of respiratory nor renal failure were the immediate reason for applying to the doctor, but in two the rapid onset of hypoacusis combined with purulent discharge and facial nerve palsy and in two quick progression of mixed type hypoacusis.
    Results: The age of the patients ranged from 32 to 46. The outcome of initially otologic cases, which developed generalized form of WG was poor (first died after 2 months, second after 7 days, third in a two-month observation had the pulmonary insufficiency, fourth in one month had severe renal failure), whereas other 3 patients with localized form of the disease have been successfully under control for 3-5 years.
    Conclusions: As Wegeners granulomatosis in some cases presents ENT problems as an initial sign, it is important to take it into consideration in atypical inflammatory states of the ear. The otologic onset of WG is very insidious and prompt diagnosis in early stage of disease is a challenge.
    MeSH term(s) Adult ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Facial Paralysis/drug therapy ; Facial Paralysis/etiology ; Female ; Granulomatosis with Polyangiitis/complications ; Granulomatosis with Polyangiitis/diagnosis ; Hearing Loss, Sensorineural/etiology ; Humans ; Immunologic Factors/therapeutic use ; Male ; Middle Aged ; Otitis Media with Effusion/drug therapy ; Otitis Media with Effusion/etiology ; Rituximab
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Immunologic Factors ; Rituximab (4F4X42SYQ6)
    Language Polish
    Publishing date 2012-07
    Publishing country Poland
    Document type English Abstract ; Journal Article ; Review
    ZDB-ID 417458-6
    ISSN 2300-8423 ; 0030-6657
    ISSN (online) 2300-8423
    ISSN 0030-6657
    DOI 10.1016/j.otpol.2012.05.013
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  7. Article: Die otologische Manifestation der Wegenerschen Granulomatose.

    Frank, W / Münzel, M

    Laryngologie, Rhinologie, Otologie

    1985  Volume 64, Issue 10, Page(s) 527–531

    Abstract: Ever since Wegener first described the granulomatosis named after him, involvement ... of the middle ear with Wegener's granulomatosis. The corresponding symptoms clearly precede the affection ... typical of Wegener's granulomatosis concerning the nasal mucosa, trachea and especially the kidneys set ...

    Title translation Otologic manifestation of Wegener granulomatosis.
    Abstract Ever since Wegener first described the granulomatosis named after him, involvement of the middle ear tracts as a consequence of inflammatory changes in the nose and the nasopharynx has been known. In recent years there have been a remarkable number of reports on a primary affection of the mucosa of the middle ear with Wegener's granulomatosis. The corresponding symptoms clearly precede the affection of the typical parts of predilection in the upper respiratory tract. A 37-year old woman patient is reported to have fallen ill with a primary left-sided serous otitis media. Only several months later the changes typical of Wegener's granulomatosis concerning the nasal mucosa, trachea and especially the kidneys set in. The differential diagnostic difficulties appear with respect to the classification of inflammatory granulomatosis of the mucosa of the middle ear. The now valid concept of chemotherapy regarding treatment with cyclophosphamide and corticosteroids. Premature therapy can achieve encouragingly long remission of a relatively high number of cases of this disease.
    MeSH term(s) Adult ; Diagnosis, Differential ; Ear, Middle/pathology ; Female ; Granulomatosis with Polyangiitis/pathology ; Hearing Loss, Conductive/pathology ; Humans ; Mucous Membrane/pathology ; Otitis Media with Effusion/pathology
    Language German
    Publishing date 1985-10
    Publishing country Germany
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 125070-x
    ISSN 0340-1588 ; 0302-9379
    ISSN 0340-1588 ; 0302-9379
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Otologische Erstmanifestation der Wegenerschen-Granulomatose.

    Leibecke, R R / Schwartz, W

    HNO

    1994  Volume 42, Issue 2, Page(s) 119–122

    Abstract: In most patients the first symptoms of Wegener's granulomatosis (WG) originates in the ENT-area ... with initial symptoms of otalgia followed by a rapidly progressive course is reported in a case. Prognosis ...

    Title translation Initial otologic manifestation of Wegener's granulomatosis.
    Abstract In most patients the first symptoms of Wegener's granulomatosis (WG) originates in the ENT-area. As a consequence, their prompt recognition allows diagnosis of the disease in an early stage. The beginning of WG with initial symptoms of otalgia followed by a rapidly progressive course is reported in a case. Prognosis in WG currently depends on making an early diagnosis and is improved by well-timed and sufficient therapy.
    MeSH term(s) Combined Modality Therapy ; Diagnosis, Differential ; Granulomatosis with Polyangiitis/diagnosis ; Granulomatosis with Polyangiitis/pathology ; Granulomatosis with Polyangiitis/surgery ; Hearing Loss, Conductive/diagnosis ; Hearing Loss, Conductive/pathology ; Hearing Loss, Conductive/surgery ; Humans ; Immunosuppressive Agents/administration & dosage ; Male ; Mastoid/pathology ; Mastoid/surgery ; Mastoiditis/diagnosis ; Mastoiditis/pathology ; Mastoiditis/surgery ; Middle Aged ; Otitis Media with Effusion/diagnosis ; Otitis Media with Effusion/pathology ; Otitis Media with Effusion/surgery
    Chemical Substances Immunosuppressive Agents
    Language German
    Publishing date 1994-02
    Publishing country Germany
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 200040-4
    ISSN 1433-0458 ; 0017-6192
    ISSN (online) 1433-0458
    ISSN 0017-6192
    Database MEDical Literature Analysis and Retrieval System OnLINE

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