Article: Insights into the neurodegenerative process of Alzheimer's disease: a role for mononuclear phagocyte-associated inflammation and neurotoxicity.
1999 Volume 65, Issue 4, Page(s) 416–427
Abstract: ... the disease process and in providing effective therapeutics to prevent and/or retard the devastating ... of genetic linkages for disease, into elucidating the structure and function of the etiologic beta-amyloid protein ... Since the first description of Alzheimer's disease (AD) in 1907, significant progress was made ...
| Abstract | Since the first description of Alzheimer's disease (AD) in 1907, significant progress was made into understanding disease pathophysiology. The enormous effort in AD research has translated into the discovery of genetic linkages for disease, into elucidating the structure and function of the etiologic beta-amyloid protein, and into unraveling the seemingly complex neuroimmunological cascade that affects neuronal dysfunction. Although effective therapies do not currently exist, many are being developed. We propose that the neuropathogenesis of AD, in measure, revolves around the immunological activation of glial cells, which in turn leads to alterations in inflammatory neurotoxin production, and ultimately to neuronal injury and death. Elucidating the mechanisms involved in such glial cell immune activation should provide valuable insights into understanding the disease process and in providing effective therapeutics to prevent and/or retard the devastating neurodegeneration that afflicts so many of our elderly. |
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| MeSH term(s) | Alzheimer Disease/epidemiology ; Alzheimer Disease/immunology ; Alzheimer Disease/pathology ; Animals ; Humans ; Inflammation/immunology ; Leukocytes, Mononuclear/immunology ; Neurodegenerative Diseases/immunology ; Neurotoxins/immunology ; Phagocytes/immunology | |||||
| Chemical Substances | Neurotoxins | |||||
| Language | English | |||||
| Publishing date | 1999-04 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 605722-6 | |||||
| ISSN | 1938-3673 ; 0741-5400 | |||||
| ISSN (online) | 1938-3673 | |||||
| ISSN | 0741-5400 | |||||
| DOI | 10.1002/jlb.65.4.416 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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