Article ; Online: Obesity is a Major Risk Factor for Hospitalization in Community-Managed COVID-19 Pneumonia.
2021 Volume 96, Issue 4, Page(s) 921–931
Abstract: ... pneumonia, obesity is associated with a higher hospitalization risk and overall worse outcomes ... disease 2019 (COVID-19) pneumonia by body mass index (BMI) can help predict hospitalization and ... significantly associated with obesity (P<.001).: Conclusion: In patients with community-managed COVID-19 ...
| Abstract | Objective: We aimed to investigate whether the stratification of outpatients with coronavirus disease 2019 (COVID-19) pneumonia by body mass index (BMI) can help predict hospitalization and other severe outcomes. Patients and methods: We prospectively collected consecutive cases of community-managed COVID-19 pneumonia from March 1 to April 20, 2020, in the province of Bergamo and evaluated the association of overweight (25 kg/m Results: Of 338 patients included, 133 (39.4%) were overweight and 77 (22.8%) were obese. Age at diagnosis was younger in obese patients compared with those overweight or with normal weight (P<.001), whereas diabetes, dyslipidemia, and heart diseases were differently distributed among BMI categories. Azithromycin, hydroxychloroquine, and prednisolone use were similar between BMI categories (P>.05). Overall, 105 (31.1%) patients were hospitalized, and time to hospitalization was significantly shorter for obese vs over- or normal-weight patients (P<.001). In the final multivariable analysis, obese patients were more likely to require hospitalization than nonobese patients (hazard ratio, 5.83; 95% CI, 3.91 to 8.71). Results were similar in multiple sensitivity analyses. Low-flow domiciliary oxygen need, hospitalization with noninvasive mechanical ventilation, intubation, and death were significantly associated with obesity (P<.001). Conclusion: In patients with community-managed COVID-19 pneumonia, obesity is associated with a higher hospitalization risk and overall worse outcomes than for nonobese patients. |
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| MeSH term(s) | Age Factors ; Body Mass Index ; COVID-19/epidemiology ; COVID-19/therapy ; Community Health Services/methods ; Community Health Services/statistics & numerical data ; Comorbidity ; Female ; Hospitalization/statistics & numerical data ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Obesity/diagnosis ; Obesity/epidemiology ; Outcome and Process Assessment, Health Care ; Pneumonia, Viral/etiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Proportional Hazards Models ; Risk Assessment/methods ; Risk Factors ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-02-04 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 124027-4 | |||||
| ISSN | 1942-5546 ; 0025-6196 | |||||
| ISSN (online) | 1942-5546 | |||||
| ISSN | 0025-6196 | |||||
| DOI | 10.1016/j.mayocp.2021.01.021 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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