Article ; Online: Low birth weight as a potential risk factor for severe COVID-19 in adults.
2021 Volume 11, Issue 1, Page(s) 2909
Abstract: ... disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects ... 95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly ... The identification of factors predisposing to severe COVID-19 in young adults remains partially ...
| Abstract | The identification of factors predisposing to severe COVID-19 in young adults remains partially characterized. Low birth weight (LBW) alters cardiovascular and lung development and predisposes to adult disease. We hypothesized that LBW is a risk factor for severe COVID-19 in non-elderly subjects. We analyzed a prospective cohort of 397 patients (18-70 years) with laboratory-confirmed SARS-CoV-2 infection attended in a tertiary hospital, where 15% required admission to Intensive Care Unit (ICU). Perinatal and current potentially predictive variables were obtained from all patients and LBW was defined as birth weight ≤ 2.500 g. Age (adjusted OR (aOR) 1.04 [1-1.07], P = 0.012), male sex (aOR 3.39 [1.72-6.67], P < 0.001), hypertension (aOR 3.37 [1.69-6.72], P = 0.001), and LBW (aOR 3.61 [1.55-8.43], P = 0.003) independently predicted admission to ICU. The area under the receiver-operating characteristics curve (AUC) of this model was 0.79 [95% CI, 0.74-0.85], with positive and negative predictive values of 29.1% and 97.6% respectively. Results were reproduced in an independent cohort, from a web-based survey in 1822 subjects who self-reported laboratory-positive SARS-CoV-2 infection, where 46 patients (2.5%) needed ICU admission (AUC 0.74 [95% CI 0.68-0.81]). LBW seems to be an independent risk factor for severe COVID-19 in non-elderly adults and might improve the performance of risk stratification algorithms. |
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| MeSH term(s) | Adolescent ; Adult ; Aged ; Area Under Curve ; COVID-19/pathology ; COVID-19/virology ; Female ; Humans ; Infant, Low Birth Weight ; Intensive Care Units/statistics & numerical data ; Logistic Models ; Male ; Middle Aged ; Prospective Studies ; ROC Curve ; Risk Factors ; SARS-CoV-2/isolation & purification ; Self Report ; Severity of Illness Index ; Surveys and Questionnaires ; Tertiary Care Centers ; Young Adult |
| Language | English |
| Publishing date | 2021-02-03 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2615211-3 |
| ISSN | 2045-2322 ; 2045-2322 |
| ISSN (online) | 2045-2322 |
| ISSN | 2045-2322 |
| DOI | 10.1038/s41598-021-82389-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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