Article ; Online: MMP-2 and MMP-9 levels in plasma are altered and associated with mortality in COVID-19 patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
2021 Volume 142, Page(s) 112067
Abstract: ... that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP ... of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association ... between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels ...
| Abstract | Respiratory symptoms are one of COVID-19 manifestations, and the metalloproteinases (MMPs) have essential roles in the lung physiology. We sought to characterize the plasmatic levels of matrix metalloproteinase-2 and 9 (MMP-2 and MMP-9) in patients with severe COVID-19 and to investigate an association between plasma MMP-2 and MMP-9 levels and clinical outcomes and mortality. MMP-2 and MMP-9 levels in plasma from patients with COVID-19 treated in the ICU (COVID-19 group) and Control patients were measured with the zymography. The study groups were matched for age, sex, hypertension, diabetes, BMI, and obesity profile. MMP-2 levels were lower and MMP-9 levels were higher in a COVID-19 group (p < 0.0001) compared to Controls. MMP-9 levels in COVID-19 patients were not affected by comorbidity such as hypertension or obesity. MMP-2 levels were affected by hypertension (p < 0.05), but unaffected by obesity status. Notably, hypertensive COVID-19 patients had higher MMP-2 levels compared to the non-hypertensive COVID-19 group, albeit still lower than Controls (p < 0.05). No association between MMP-2 and MMP-9 plasmatic levels and corticosteroid treatment or acute kidney injury was found in COVID-19 patients. The survival analysis showed that COVID-19 mortality was associated with increased MMP-2 and MMP-9 levels. Age, hypertension, BMI, and MMP-2 and MMP-9 were better predictors of mortality during hospitalization than SAPS3 and SOFA scores at hospital admission. In conclusion, a significant association between MMP-2 and MMP-9 levels and COVID-19 was found. Notably, MMP-2 and MMP-9 levels predicted the risk of in-hospital death suggesting possible pathophysiologic and prognostic roles. |
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| MeSH term(s) | Age Factors ; Body Mass Index ; Brazil/epidemiology ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/mortality ; COVID-19/physiopathology ; Female ; Hospital Mortality ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Intensive Care Units/statistics & numerical data ; Male ; Matrix Metalloproteinase 2/analysis ; Matrix Metalloproteinase 2/blood ; Matrix Metalloproteinase 9/analysis ; Matrix Metalloproteinase 9/blood ; Middle Aged ; Mortality ; Predictive Value of Tests ; Prognosis ; Risk Factors ; SARS-CoV-2 ; Severity of Illness Index | |||||
| Chemical Substances | Matrix Metalloproteinase 2 (EC 3.4.24.24) ; Matrix Metalloproteinase 9 (EC 3.4.24.35) | |||||
| Language | English | |||||
| Publishing date | 2021-08-20 | |||||
| Publishing country | France | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 392415-4 | |||||
| ISSN | 1950-6007 ; 0753-3322 ; 0300-0893 | |||||
| ISSN (online) | 1950-6007 | |||||
| ISSN | 0753-3322 ; 0300-0893 | |||||
| DOI | 10.1016/j.biopha.2021.112067 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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