Article ; Online: Long-term clinical follow-up of patients suffering from moderate-to-severe COVID-19 infection: a monocentric prospective observational cohort study.
2021 Volume 109, Page(s) 209–216
Abstract: ... sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 (COVID-19) in Liège ... of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion ... admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between ...
| Abstract | Objectives: Various symptoms and considerable organ dysfunction persist following infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Uncertainty remains about the potential mid- and long-term health sequelae. This prospective study of patients hospitalized with coronavirus disease 2019 (COVID-19) in Liège University Hospital, Belgium aimed to determine the persistent consequences of COVID-19. Methods: Patients admitted to the University Hospital of Liège with moderate-to-severe confirmed COVID-19, discharged between 2 March and 1 October 2020, were recruited prospectively. Follow-up at 3 and 6 months after hospital discharge included demographic and clinical data, biological data, pulmonary function tests (PFTs) and high-resolution computed tomography (CT) scans of the chest. Results: In total, 199 individuals were included in the analysis. Most patients received oxygen supplementation (80.4%). Six months after discharge, 47% and 32% of patients still had exertional dyspnoea and fatigue. PFTs at 3-month follow-up revealed a reduced diffusion capacity of carbon monoxide (mean 71.6 ± 18.6%), and this increased significantly at 6-month follow-up (P<0.0001). Chest CT scans showed a high prevalence (68.9% of the cohort) of persistent abnormalities, mainly ground glass opacities. Duration of hospitalization, intensive care unit admission and mechanical ventilation were not associated with the persistence of symptoms 3 months after discharge. Conclusion: The prevalence of persistent symptoms following hospitalization with COVID-19 is high and stable for up to 6 months after discharge. However, biological, functional and iconographic abnormalities improved significantly over time. |
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| MeSH term(s) | COVID-19 ; Cohort Studies ; Follow-Up Studies ; Humans ; Prospective Studies ; SARS-CoV-2 | |||||
| Language | English | |||||
| Publishing date | 2021-07-14 | |||||
| Publishing country | Canada | |||||
| Document type | Journal Article ; Observational Study | |||||
| ZDB-ID | 1331197-9 | |||||
| ISSN | 1878-3511 ; 1201-9712 | |||||
| ISSN (online) | 1878-3511 | |||||
| ISSN | 1201-9712 | |||||
| DOI | 10.1016/j.ijid.2021.07.016 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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