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Article ; Online: Neurological Insights of COVID-19 Pandemic.

Das, Gaurav / Mukherjee, Nabanita / Ghosh, Surajit

ACS chemical neuroscience

2020 Volume 11, Issue 9, Page(s) 1206–1209

Abstract: ... In this Viewpoint, we provide a brief outline of the currently known neurological manifestations of COVID-19 and ... emerge as the new abode of the virus. Already instances of patients with COVID-19 have been reported ... specific therapeutic strategies with the available information to counteract the pandemic ...

Abstract	The novel coronavirus SARS-CoV-2, which was identified after a recent outbreak in Wuhan, China, in December 2019, has kept the whole world in tenterhooks due to its severe life-threatening nature of the infection. The virus is unlike its previous counterparts, SARS-CoV and MERS-CoV, or anything the world has encountered before both in terms of virulence and severity of the infection. If scientific reports relevant to the SARS-CoV-2 virus are noted, it can be seen that the virus owes much of its killer properties to its unique structure that has a stronger binding affinity with the human angiotensin-converting enzyme 2 (hACE2) protein, which the viruses utilize as an entry point to gain accesses to its hosts. Recent reports suggest that it is not just the lung that the virus may be targeting; the human brain may soon emerge as the new abode of the virus. Already instances of patients with COVID-19 have been reported with mild (anosmia and ageusia) to severe (encephalopathy) neurological manifestations, and if that is so, then it gives us more reasons to be frightened of this killer virus. Keeping in mind that the situation does not worsen from here, immediate awareness and more thorough research regarding the neuroinvasive nature of the virus is the immediate need of the hour. Scientists globally also need to up their game to design more specific therapeutic strategies with the available information to counteract the pandemic. In this Viewpoint, we provide a brief outline of the currently known neurological manifestations of COVID-19 and discuss some probable ways to design therapeutic strategies to overcome the present global crisis.
MeSH term(s)	Aged ; Ageusia/virology ; Angiotensin-Converting Enzyme 2 ; Autopsy ; BCG Vaccine/administration & dosage ; BCG Vaccine/immunology ; Betacoronavirus/chemistry ; Betacoronavirus/metabolism ; Betacoronavirus/pathogenicity ; Brain/pathology ; Brain/physiopathology ; Brain/virology ; Brain Diseases/immunology ; Brain Diseases/pathology ; Brain Diseases/virology ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/physiopathology ; Coronavirus Infections/transmission ; Coronavirus Infections/virology ; Cytokines/immunology ; Humans ; Inflammation/immunology ; Inflammation/pathology ; Inflammation/virology ; MicroRNAs/genetics ; Olfaction Disorders/virology ; Olfactory Mucosa/pathology ; Olfactory Mucosa/physiopathology ; Olfactory Mucosa/virology ; Pandemics ; Peptidyl-Dipeptidase A/genetics ; Peptidyl-Dipeptidase A/metabolism ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/immunology ; Pneumonia, Viral/pathology ; Pneumonia, Viral/physiopathology ; Pneumonia, Viral/transmission ; Pneumonia, Viral/virology ; RNA Interference ; Receptors, Nicotinic/metabolism ; SARS-CoV-2 ; Serine Endopeptidases/metabolism ; Smoking/metabolism ; Smoking/pathology ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism
Chemical Substances	BCG Vaccine ; Cytokines ; MIRN27 microRNA, human ; MicroRNAs ; Receptors, Nicotinic ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; Serine Endopeptidases (EC 3.4.21.-) ; TMPRSS2 protein, human (EC 3.4.21.-)
Keywords	covid19
Language	English
Publishing date	2020-04-22
Publishing country	United States
Document type	Journal Article
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.0c00201
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Neurological Insights of COVID-19 Pandemic

Das, Gaurav / Mukherjee, Nabanita / Ghosh, Surajit

ACS Chemical Neuroscience

2020 Volume 11, Issue 9, Page(s) 1206–1209

Keywords	Cell Biology ; Biochemistry ; Physiology ; Cognitive Neuroscience ; General Medicine ; covid19
Language	English
Publisher	American Chemical Society (ACS)
Publishing country	us
Document type	Article ; Online
ISSN	1948-7193
DOI	10.1021/acschemneuro.0c00201
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Neurological Insights of COVID-19 Pandemic

Das, Gaurav / Mukherjee, Nabanita / Ghosh, Surajit

ACS Chem Neurosci

Abstract	The novel coronavirus SARS-CoV-2, which was identified after a recent outbreak in Wuhan, China, in December 2019, has kept the whole world in tenterhooks due to its severe life-threatening nature of the infection. The virus is unlike its previous counterparts, SARS-CoV and MERS-CoV, or anything the world has encountered before both in terms of virulence and severity of the infection. If scientific reports relevant to the SARS-CoV-2 virus are noted, it can be seen that the virus owes much of its killer properties to its unique structure that has a stronger binding affinity with the human angiotensin-converting enzyme 2 (hACE2) protein, which the viruses utilize as an entry point to gain accesses to its hosts. Recent reports suggest that it is not just the lung that the virus may be targeting; the human brain may soon emerge as the new abode of the virus. Already instances of patients with COVID-19 have been reported with mild (anosmia and ageusia) to severe (encephalopathy) neurological manifestations, and if that is so, then it gives us more reasons to be frightened of this killer virus. Keeping in mind that the situation does not worsen from here, immediate awareness and more thorough research regarding the neuroinvasive nature of the virus is the immediate need of the hour. Scientists globally also need to up their game to design more specific therapeutic strategies with the available information to counteract the pandemic. In this Viewpoint, we provide a brief outline of the currently known neurological manifestations of COVID-19 and discuss some probable ways to design therapeutic strategies to overcome the present global crisis.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #101631
Database	COVID19

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Article ; Online: Correlation between CNS Tuberculosis and the COVID-19 Pandemic: The Neurological and Therapeutic Insights.

Mandal, Narattam / De, Nayan / Jana, Pulak / Sannigrahi, Achinta / Chattopadhyay, Krishnananda

ACS chemical neuroscience

2020 Volume 11, Issue 18, Page(s) 2789–2792

Abstract: ... in neurological disorders of COVID-19 with CNS tuberculosis, which suggests that some anti-tubercular drugs may be used ... peripheral nervous system (PNS) due to COVID-19 infection are now identified. We demonstrate here an apparent similarity ... as therapeutic agents against COVID-19 infection. ...

Abstract	The recent outbreak of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) from Wuhan, China, was caused by a single-stranded RNA virus which has kept the entire world stranded. The outbreak was first diagnosed with respiratory illness, but recent findings of acute necrotizing hemorrhage of brain, brain encephalopathy, and the presence of the virus in the cerebrospinal fluid (CSF) have unveiled its neuroinvasivness. Various clinical features related to the central nervous system (CNS) and peripheral nervous system (PNS) due to COVID-19 infection are now identified. We demonstrate here an apparent similarity in neurological disorders of COVID-19 with CNS tuberculosis, which suggests that some anti-tubercular drugs may be used as therapeutic agents against COVID-19 infection.
MeSH term(s)	Animals ; Betacoronavirus ; Brain/virology ; COVID-19 ; Central Nervous System Diseases/virology ; Coronavirus Infections/complications ; Humans ; Pandemics ; Pneumonia, Viral/complications ; SARS-CoV-2 ; Tuberculosis, Central Nervous System/immunology ; Tuberculosis, Central Nervous System/pathology ; Tuberculosis, Central Nervous System/physiopathology
Keywords	covid19
Language	English
Publishing date	2020-09-03
Publishing country	United States
Document type	Journal Article ; Review
ISSN	1948-7193
ISSN (online)	1948-7193
DOI	10.1021/acschemneuro.0c00546
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Correlation between CNS Tuberculosis and the COVID-19 Pandemic: The Neurological and Therapeutic Insights

Mandal, Narattam / De, Nayan / Jana, Pulak / Sannigrahi, Achinta / Chattopadhyay, Krishnananda

ACS Chem Neurosci

Abstract	The recent outbreak of Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2) from Wuhan, China, was caused by a single-stranded RNA virus which has kept the entire world stranded. The outbreak was first diagnosed with respiratory illness, but recent findings of acute necrotizing hemorrhage of brain, brain encephalopathy, and the presence of the virus in the cerebrospinal fluid (CSF) have unveiled its neuroinvasivness. Various clinical features related to the central nervous system (CNS) and peripheral nervous system (PNS) due to COVID-19 infection are now identified. We demonstrate here an apparent similarity in neurological disorders of COVID-19 with CNS tuberculosis, which suggests that some anti-tubercular drugs may be used as therapeutic agents against COVID-19 infection.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #744340
Database	COVID19

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Article ; Online: Neurological risks of COVID-19 in women: the complex immunology underpinning sex differences.

Gu, Jienan / Zhang, Jiale / Liu, Qianhui / Xu, Shijie

Frontiers in immunology

2023 Volume 14, Page(s) 1281310

Abstract: The COVID-19 pandemic has uncovered many mysteries about SARS-CoV-2, including its potential ... with the observed neurological sequelae in women. An intentional focus on elucidating sex differences in COVID-19 ... on how COVID-19 infection can lead to immune tolerance loss, enabling autoreactive antibodies and ...

Abstract	The COVID-19 pandemic has uncovered many mysteries about SARS-CoV-2, including its potential to trigger abnormal autoimmune responses. Emerging evidence suggests women may face higher risks from COVID-induced autoimmunity manifesting as persistent neurological symptoms. Elucidating the mechanisms underlying this female susceptibility is now imperative. We synthesize key insights from existing studies on how COVID-19 infection can lead to immune tolerance loss, enabling autoreactive antibodies and lymphocyte production. These antibodies and lymphocytes infiltrate the central nervous system. Female sex hormones like estrogen and X-chromosome mediated effects likely contribute to dysregulated humoral immunity and cytokine profiles among women, increasing their predisposition. COVID-19 may also disrupt the delicate immunological balance of the female microbiome. These perturbations precipitate damage to neural damage through mechanisms like demyelination, neuroinflammation, and neurodegeneration - consistent with the observed neurological sequelae in women. An intentional focus on elucidating sex differences in COVID-19 pathogenesis is now needed to inform prognosis assessments and tailored interventions for female patients. From clinical monitoring to evaluating emerging immunomodulatory therapies, a nuanced women-centered approach considering the hormonal status and immunobiology will be vital to ensure equitable outcomes. Overall, deeper insights into the apparent female specificity of COVID-induced autoimmunity will accelerate the development of solutions mitigating associated neurological harm.
MeSH term(s)	Humans ; Female ; Male ; COVID-19 ; SARS-CoV-2 ; Sex Characteristics ; Pandemics ; Estrogens
Chemical Substances	Estrogens
Language	English
Publishing date	2023-11-14
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1281310
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A Systematic Review Unraveling the Intricate Neurological Spectrum of COVID-19: Manifestations, Complications, and Transformative Insights for Patient Care.

Pitliya, Aakanksha / Dhamecha, Jatin / Kumar, Deepak / Anusha, Kvn / Kancherla, Neeraj / Kumar, Lakshya / Singla, Ramit / Pitliya, Anmol

Neurology India

2024 Volume 72, Issue 1, Page(s) 11–19

Abstract: The coronavirus disease 2019 (COVID-19) pandemic has strained global healthcare and financial ... infrastructures. Neurological manifestations of COVID-19 have gained recognition, emphasizing the need ... manifestations varied from 29.1% to 84.8%. The study underscores the complex neurological impact of COVID-19, affecting ...

Abstract	The coronavirus disease 2019 (COVID-19) pandemic has strained global healthcare and financial infrastructures. Neurological manifestations of COVID-19 have gained recognition, emphasizing the need for comprehensive research in this area. This systematic review aims to comprehensively examine the neurological manifestations and complications associated with COVID-19 and assess their prevalence, impact on patient outcomes, and potential relationships with comorbidities, while emphasizing the significance of ongoing research in this field. We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 guidelines. A comprehensive search of PubMed, Google Scholar, Science Direct, and ResearchGate databases was conducted to identify eligible studies focusing on COVID-19 patients, reporting neurological symptoms or complications, and published between 2020 and 2022 in English. The data extracted is performed in a Microsoft Excel spreadsheet. Two independent reviewers assessed study quality and bias using the AMSTAR 2 scale before inclusion. This systematic includes 12 systematic reviews and meta-analysis with 191,412 participants and average age of 60 years. Neurological symptoms included headaches, dizziness, anosmia, and ageusia. Complications ranged from cerebrovascular events to Guillain-Barré syndrome. Comorbidities, such as hypertension and diabetes, exacerbated severity. Mortality rates associated with neurological manifestations varied from 29.1% to 84.8%. The study underscores the complex neurological impact of COVID-19, affecting patients across age groups. Ongoing research is vital to understand mechanisms and develop targeted interventions, improving patient care and addressing pandemic consequences. This review provides a holistic view of COVID-19's neurological effects, emphasizing the need for sustained research efforts and collaborative endeavors to combat the neurological issues.
MeSH term(s)	Humans ; COVID-19/complications ; Nervous System Diseases/virology
Language	English
Publishing date	2024-02-29
Publishing country	India
Document type	Journal Article ; Systematic Review
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/neurol-india.Neurol-India-D-24-00003
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 698: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article: Unmasking the long-term effects: unravelling neuropsychiatric and neurological consequences of COVID-19.

Tariq, Mahnoor / Mahak, Fnu / Kumar, Rahul / Kumar, Ajay / Kumar, Anish / Khan, Javeria / Muhammad, Marvi Ali / Memon, Unaiza / Maqsood, Kanza Mirza / Tanveer, Fariha Shahid / Gill, Anosh / Jawed, Areesha / Shrestha, Sunita / Waheed, Muhammad Hamza

Annals of medicine and surgery (2012)

2024 Volume 86, Issue 3, Page(s) 1490–1495

Abstract: The COVID-19 pandemic has not only burdened healthcare systems but has also led to a new emerging ... research to decode the long-term impacts of COVID-19 on neurological and mental health. Drawing ... medical enigma that is post-COVID-19 syndrome or "long COVID." Characterized by persistent symptoms ...

Abstract	The COVID-19 pandemic has not only burdened healthcare systems but has also led to a new emerging medical enigma that is post-COVID-19 syndrome or "long COVID." Characterized by persistent symptoms that extend beyond the acute phase of the illness, long COVID has rapidly become a public health concern with ambiguous neurological and neuropsychiatric dimensions. This narrative review aims at synthesizing available research to decode the long-term impacts of COVID-19 on neurological and mental health. Drawing from a multitude of studies, this review synthesizes evidence on various neuropsychiatric and neurological symptoms, including cognitive deficits, mood disorders, and more. The narrative delves into potential pathogenic mechanisms, hoping to fill existing research gaps and offering directions for future inquiry. The objective is not just academic; it has immediate real-world implications. Understanding these long-term effects is crucial for developing effective treatments and interventions, thereby better serving the millions of individuals living with these lingering symptoms. As healthcare systems continue to grapple with the fallout from the pandemic, this review provides much-needed context and insights into an area that demands urgent research and action.
Language	English
Publishing date	2024-01-04
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2745440-X
ISSN	2049-0801
ISSN	2049-0801
DOI	10.1097/MS9.0000000000001624
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Article ; Online: Management of Neurological Emergencies in Children: An Updated Overview.

Mastrangelo, Mario / Baglioni, Valentina

Neuropediatrics

2021 Volume 52, Issue 4, Page(s) 242–251

Abstract: ... of the current novel coronavirus disease2019 (COVID-19) pandemic on the evaluation of pediatric neurologic ... of pediatric neurological emergencies. Particularly, details will be provided about the most recent insights ... This review highlights updated insights about clinical features, diagnostic workup, and therapeutic management ...

Abstract	Neurological emergencies account for about one-third of the highest severity codes attributed in emergency pediatric departments. About 75% of children with acute neurological symptoms presents with seizures, headache, or other paroxysmal events. Life-threatening conditions involve a minor proportion of patients (e.g., less than 15% of children with headache and less than 5% of children with febrile seizures). This review highlights updated insights about clinical features, diagnostic workup, and therapeutic management of pediatric neurological emergencies. Particularly, details will be provided about the most recent insights about headache, febrile seizures, status epilepticus, altered levels of consciousness, acute motor impairment, acute movement disorders, and functional disorders, as well as the role of diagnostic tools (e.g., neuroimaging, lumbar puncture, and electroencephalography), in the emergency setting. Moreover, the impact of the current novel coronavirus disease2019 (COVID-19) pandemic on the evaluation of pediatric neurologic emergencies will also be analyzed.
Language	English
Publishing date	2021-06-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	573291-8
ISSN	1439-1899 ; 0174-304X
ISSN (online)	1439-1899
ISSN	0174-304X
DOI	10.1055/s-0041-1730936
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Zs.A 728: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Crosstalk between SARS-CoV-2 Infection and Neurological Disorders: A Review.

Azhar, Asim / Wali, Mohammad Akram / Rashid, Qudsia / Khan, Wajihul Hasan / Al-Hosaini, Khaled / Owais, Mohammad / Kamal, Mohammad Amjad

CNS & neurological disorders drug targets

2022 Volume 22, Issue 5, Page(s) 643–658

Abstract: ... of COVID-19 have widely been explained in the last couple of months of the pandemic. Initially, the virus ... in the majority of COVID-19 patients with neurological symptoms, the penetration of SARS-CoV-2 ... developing. The present comprehensive review will gain insights and provide neurological dimensions of COVID ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent responsible for coronavirus disease (COVID-19), is an issue of global concern since March 2020. The respiratory manifestations of COVID-19 have widely been explained in the last couple of months of the pandemic. Initially, the virus was thought to be restricted to the pulmonary system; however, as time progressed and cases increased during the second wave of COVID-19, the virus affected other organs, including the nervous system. The neurological implication of SARS-CoV-2 infection is mounting, as substantiated by various reports, and in the majority of COVID-19 patients with neurological symptoms, the penetration of SARS-CoV-2 in the central nervous system (CNS) is likely. SARS-CoV-2 can enter the nervous system by exploiting the routes of olfactory mucosa, olfactory and sensory nerve endings, or endothelial and nerve tissues, thus crossing the neural-mucosal interface in the olfactory mucosa in the nose. Owing to multifactorial and complex pathogenic mechanisms, COVID-19 adds a large-scale risk to the entire nervous system. A thorough understanding of SARSCoV- 2 neurological damage is still vague; however, our comprehension of the virus is rapidly developing. The present comprehensive review will gain insights and provide neurological dimensions of COVID-19 and their associated anomalies. The review presents the entry routes of SARS-CoV-2 into the CNS to ascertain potential targets in the tissues owing to infection. We also discuss the molecular mechanisms involved, the array of clinical symptoms, and various nervous system diseases following the attack of SARS-CoV-2.
MeSH term(s)	Humans ; COVID-19/complications ; SARS-CoV-2 ; Nervous System Diseases ; Central Nervous System ; Pandemics
Language	English
Publishing date	2022-04-19
Publishing country	United Arab Emirates
Document type	Review ; Journal Article
ZDB-ID	2228394-8
ISSN	1996-3181 ; 1871-5273
ISSN (online)	1996-3181
ISSN	1871-5273
DOI	10.2174/1871527321666220418114009
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5892: Show issues

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Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

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