Article ; Online: Carvacrol promotes neuroprotection in the mouse hemiparkinsonian model.
2017 Volume 356, Page(s) 176–181
Abstract: ... a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson's disease, possibly by its non ... Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models ... of carvacrol in that model of Parkinson's disease, and immunoblots to evaluate the levels of caspase-3 and ...
| Abstract | Carvacrol is a monoterpene that has been linked to neuroprotection in several animal models of neurodegeneration, including ischemia, epilepsy and traumatic neuronal injury. In this study, we investigated the effects of carvacrol (i.p.) upon the neurodegeneration induced by 6-hydroxy-dopamine unilateral intrastriatal injections in mice. We have also used the cylinder test to assess the behavioral effects of carvacrol in that model of Parkinson's disease, and immunoblots to evaluate the levels of caspase-3 and TRPM7, one of major targets of carvacrol. Behavioral testing revealed that carvacrol largely reduced the asymmetrical use of the forelimbs induced by unilateral 6-hydroxy-dopamine. Carvacrol dramatically reduced the loss of tyrosine hydroxylase immunostaining both in the substantia nigra and in the striatum that are typical of the model. Immunoblots for tyrosine hydroxylase confirmed this effect. Caspase-3 levels were very high after toxin injections, but carvacrol appeared to reduce them to control levels. Finally, TRPM7, observed by immunoblots, increased after 6-hydroxy-dopamine, suggesting the involvement of this cation channel in the ensuing neurodegenerative process. The present data suggest that carvacrol promotes a marked neuroprotection in the 6-hydroxy-dopamine model of Parkinson's disease, possibly by its non-specific blocking effect upon TRPM7 channels. |
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| MeSH term(s) | Animals ; Disease Models, Animal ; Male ; Mice, Inbred C57BL ; Monoterpenes/pharmacology ; Neurons/drug effects ; Neurons/metabolism ; Neuroprotection/drug effects ; Neuroprotective Agents/pharmacology ; Parkinson Disease/drug therapy ; Substantia Nigra/drug effects | |||||
| Chemical Substances | Monoterpenes ; Neuroprotective Agents ; carvacrol (9B1J4V995Q) | |||||
| Language | English | |||||
| Publishing date | 2017-05-17 | |||||
| Publishing country | United States | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't | |||||
| ZDB-ID | 196739-3 | |||||
| ISSN | 1873-7544 ; 0306-4522 | |||||
| ISSN (online) | 1873-7544 | |||||
| ISSN | 0306-4522 | |||||
| DOI | 10.1016/j.neuroscience.2017.05.013 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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