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  1. Article: Prognostic value of Cardiac Biomarkers in COVID-19 Infection: A Meta-analysis.

    Dawson, Desiree / Dominic, Paari / Sheth, Aakash / Modi, Malak

    Research square

    2020  

    Abstract: ... ...

    Abstract Background
    Keywords covid19
    Language English
    Publishing date 2020-06-13
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-34729/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Prognostic value of Cardiac Biomarkers in COVID-19 Infection: A Meta-analysis

    Dawson, Desiree / Dominic, Paari / Sheth, Aakash / Modi, Malak

    Research square

    Abstract: ... of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data ... 014) Interpretation Cardiac biomarkers add prognostic value to the determination of the severity ... Background Multiple Biomarkers have recently been shown to be elevated in COVID-19 ...

    Abstract Background Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction;however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent Research Question The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports Study Design and Methods PubMed was searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it Results Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0 58, 95% CI 0 42-0 71, p<0 001) Cardiac injury was independently associated with significantly increased odds of mortality (OR 6 641, 95% CI 1 26 - 35 1, p=0 03) No difference in BNP was seen between the two groups A significant difference in levels of D-dimer was seen in those who died or were critically ill CK levels were only significantly higher in those who died versus those who were alive (WMD 0 47 95% CI 0 09-0 84, p=0 014) Interpretation Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #670170
    Database COVID19

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  3. Article ; Online: Prognostic value of cardiac biomarkers in COVID-19 infection.

    Sheth, Aakash / Modi, Malak / Dawson, Desiree' / Dominic, Paari

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 4930

    Abstract: ... for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 ... with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers ... Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection ...

    Abstract Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports. PubMed, Embase and Web of Science were searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived. The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model. The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it. Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0.57, 95% CI 0.43-0.70, p < 0.001). Additionally, BNP levels were also significantly higher in patients who died or were critically ill (WMD 0.45, 95% CI - 0.21-0.69, p < 0.001). Cardiac injury was independently associated with significantly increased odds of mortality (OR 6.641, 95% CI 1.26-35.1, p = 0.03). A significant difference in levels of D-dimer was seen in those who died or were critically ill. CK levels were only significantly higher in those who died versus those who were alive (WMD 0.79, 95% CI 0.25-1.33, p = 0.004). Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality.
    MeSH term(s) Biomarkers/blood ; COVID-19/blood ; COVID-19/diagnosis ; COVID-19/epidemiology ; Cardiology ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/complications ; Creatine Kinase/metabolism ; Critical Illness ; Fibrin Fibrinogen Degradation Products/analysis ; Humans ; L-Lactate Dehydrogenase/metabolism ; Myocardium/metabolism ; Natriuretic Peptide, Brain/analysis ; Peptide Fragments/analysis ; Prognosis ; Prospective Studies ; Retrospective Studies
    Chemical Substances Biomarkers ; Fibrin Fibrinogen Degradation Products ; Peptide Fragments ; fibrin fragment D ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0) ; L-Lactate Dehydrogenase (EC 1.1.1.27) ; Creatine Kinase (EC 2.7.3.2)
    Language English
    Publishing date 2021-03-02
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-84643-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Prognostic value of cardiac biomarkers in COVID-19 infection

    Aakash Sheth / Malak Modi / Desiree’ Dawson / Paari Dominic

    Scientific Reports, Vol 11, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: ... biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality. ... of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data ... Abstract Multiple Biomarkers have recently been shown to be elevated in COVID-19 ...

    Abstract Abstract Multiple Biomarkers have recently been shown to be elevated in COVID-19, a respiratory infection with multi-organ dysfunction; however, information regarding the prognostic value of cardiac biomarkers as it relates to disease severity and cardiac injury are inconsistent. The goal of this meta-analysis was to summarize the evidence regarding the prognostic relevance of cardiac biomarkers from data available in published reports. PubMed, Embase and Web of Science were searched from inception through April 2020 for studies comparing median values of cardiac biomarkers in critically ill versus non-critically ill COVID-19 patients, or patients who died versus those who survived. The weighted mean differences (WMD) and 95% confidence interval (CI) between the groups were calculated for each study and combined using a random effects meta-analysis model. The odds ratio (OR) for mortality based on cardiac injury was combined from studies reporting it. Troponin levels were significantly higher in COVID-19 patients who died or were critically ill versus those who were alive or not critically ill (WMD 0.57, 95% CI 0.43–0.70, p < 0.001). Additionally, BNP levels were also significantly higher in patients who died or were critically ill (WMD 0.45, 95% CI − 0.21–0.69, p < 0.001). Cardiac injury was independently associated with significantly increased odds of mortality (OR 6.641, 95% CI 1.26–35.1, p = 0.03). A significant difference in levels of D-dimer was seen in those who died or were critically ill. CK levels were only significantly higher in those who died versus those who were alive (WMD 0.79, 95% CI 0.25–1.33, p = 0.004). Cardiac biomarkers add prognostic value to the determination of the severity of COVID-19 and can predict mortality.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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