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  1. TI=Better Epitope Discovery Precision Immune Engineering and Accelerated Vaccine Design Using Immunoinformatics Tools
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  1. Article ; Online: Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools.

    De Groot, Anne S / Moise, Leonard / Terry, Frances / Gutierrez, Andres H / Hindocha, Pooja / Richard, Guilhem / Hoft, Daniel Fredric / Ross, Ted M / Noe, Amy R / Takahashi, Yoshimasa / Kotraiah, Vinayaka / Silk, Sarah E / Nielsen, Carolyn M / Minassian, Angela M / Ashfield, Rebecca / Ardito, Matt / Draper, Simon J / Martin, William D

    Frontiers in immunology

    2020  Volume 11, Page(s) 442

    Abstract: Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using ... computational tools. Tools that facilitate the ...

    Abstract Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the
    MeSH term(s) Animals ; Bioengineering ; Bioterrorism ; Disease Models, Animal ; Epitopes, T-Lymphocyte/genetics ; Humans ; Mass Vaccination ; Medical Informatics ; Precision Medicine/methods ; T-Lymphocytes, Regulatory/immunology ; Vaccines/genetics ; Vaccines/immunology ; Virus Diseases/immunology
    Chemical Substances Epitopes, T-Lymphocyte ; Vaccines
    Keywords covid19
    Language English
    Publishing date 2020-04-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools

    De Groot, Anne S. / Moise, Leonard / Terry, Frances / Gutierrez, Andres H. / Hindocha, Pooja / Richard, Guilhem / Hoft, Daniel Fredric / Ross, Ted M. / Noe, Amy R. / Takahashi, Yoshimasa / Kotraiah, Vinayaka / Silk, Sarah E. / Nielsen, Carolyn M. / Minassian, Angela M. / Ashfield, Rebecca / Ardito, Matt / Draper, Simon J. / Martin, William D.

    Frontiers in immunology, 11:442

    2020  

    Abstract: Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using ... cross-conserved T cell epitopes for a malaria vaccine, and analyzing immune responses in clinical ... emerging infectious diseases, and cancers can accelerate the design of novel and next generation vaccines and their delivery ...

    Abstract Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can accelerate the design of novel and next generation vaccines and their delivery to the clinic. Over the past 20 years, vaccinologists, bioinformatics experts, and advanced programmers based in Providence, Rhode Island, USA have advanced the development of an integrated toolkit for vaccine design called iVAX, that is secure and user-accessible by internet. This integrated set of immunoinformatic tools comprises algorithms for scoring and triaging candidate antigens, selecting immunogenic and conserved T cell epitopes, re-engineering or eliminating regulatory T cell epitopes, and re-designing antigens to induce immunogenicity and protection against disease for humans and livestock. Commercial and academic applications of iVAX have included identifying immunogenic T cell epitopes in the development of a T-cell based human multi-epitope Q fever vaccine, designing novel influenza vaccines, identifying cross-conserved T cell epitopes for a malaria vaccine, and analyzing immune responses in clinical vaccine studies. Animal vaccine applications to date have included viral infections of pigs such as swine influenza A, PCV2, and African Swine Fever. “Rapid-Fire” applications for biodefense have included a demonstration project for Lassa Fever and Q fever. As recent infectious disease outbreaks underscore the significance of vaccine-driven preparedness, the integrated set of tools available on the iVAX toolkit stand ready to help vaccine developers deliver genome-derived, epitope-driven vaccines.
    Keywords EpiMatrix ; COVID-19 ; T cell epitope ; ClustiMer ; immunoinformatics ; JanusMatrix ; vaccines ; Treg epitope ; bioinformatics ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Better Epitope Discovery, Precision Immune Engineering, and Accelerated Vaccine Design Using Immunoinformatics Tools

    Frontiers in immunology, 11:442

    2020  

    Abstract: Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using ... cross-conserved T cell epitopes for a malaria vaccine, and analyzing immune responses in clinical ... emerging infectious diseases, and cancers can accelerate the design of novel and next generation vaccines and their delivery ...

    Abstract Computational vaccinology includes epitope mapping, antigen selection, and immunogen design using computational tools. Tools that facilitate the in silico prediction of immune response to biothreats, emerging infectious diseases, and cancers can accelerate the design of novel and next generation vaccines and their delivery to the clinic. Over the past 20 years, vaccinologists, bioinformatics experts, and advanced programmers based in Providence, Rhode Island, USA have advanced the development of an integrated toolkit for vaccine design called iVAX, that is secure and user-accessible by internet. This integrated set of immunoinformatic tools comprises algorithms for scoring and triaging candidate antigens, selecting immunogenic and conserved T cell epitopes, re-engineering or eliminating regulatory T cell epitopes, and re-designing antigens to induce immunogenicity and protection against disease for humans and livestock. Commercial and academic applications of iVAX have included identifying immunogenic T cell epitopes in the development of a T-cell based human multi-epitope Q fever vaccine, designing novel influenza vaccines, identifying cross-conserved T cell epitopes for a malaria vaccine, and analyzing immune responses in clinical vaccine studies. Animal vaccine applications to date have included viral infections of pigs such as swine influenza A, PCV2, and African Swine Fever. “Rapid-Fire” applications for biodefense have included a demonstration project for Lassa Fever and Q fever. As recent infectious disease outbreaks underscore the significance of vaccine-driven preparedness, the integrated set of tools available on the iVAX toolkit stand ready to help vaccine developers deliver genome-derived, epitope-driven vaccines.
    Keywords ClustiMer ; EpiMatrix ; JanusMatrix ; T cell epitope ; Treg epitope ; bioinformatics ; immunoinformatics ; vaccines
    Language English
    Document type Article
    Database Repository for Life Sciences

    Full text online

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    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

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