Article ; Online: Oral isotretinoin treatment in patients with acne vulgaris during the COVID-19 pandemic: A retrospective cohort study in a tertiary care hospital.
Journal of cosmetic dermatology
2021 Volume 20, Issue 7, Page(s) 1969–1974
Abstract: ... dermatologists and acne vulgaris patients to initiate oral isotretinoin treatment safely during the pandemic ... patients had COVID-19 infection during acne vulgaris treatment. Fifteen (10.6%) patients were receiving ... outpatient clinics and seek treatment during the COVID-19 pandemic. As far as we know, the effect of isotretinoin ...
| Abstract | Background: Patients with acne vulgaris continue to present increasingly in dermatology outpatient clinics and seek treatment during the COVID-19 pandemic. As far as we know, the effect of isotretinoin on COVID-19 has not been studied before. Aim: We aimed to evaluate whether patients receiving oral isotretinoin are at increased risk of COVID-19 infection by comparing them with patients on topical treatment for acne vulgaris. Methods: The data were collected retrospectively from a cohort of 267 acne vulgaris patients, who were under follow-up for acne vulgaris treatment during the pandemic period. Results: Total of 227 patients (141 receiving isotretinoin treatment and 86 receiving topical treatment) were included of whom 29 patients had COVID-19 infection during acne vulgaris treatment. Fifteen (10.6%) patients were receiving oral isotretinoin and 14 (16.3%) were receiving topical acne treatment at the time of COVID-19 infection. The mean cumulative dose was 2340 ± 1988 mg at the time of COVID-19 infection. The mean elapsed time between the onset of isotretinoin treatment and positive PCR result for COVID-19 was 13.3 ± 10.3 weeks. Nine patients (64.3%) receiving isotretinoin treatment and 9 patients (60%) under topical treatment had loss of taste and smell during COVID-19 infection. Isotretinoin treatment was not found to be associated with a significant increased risk of getting COVID-19 (odds ratio, 0.671; 95% confidence interval, 0.247-1.823; P = 0.434). Conclusion: As a conclusion, the results of this study encourage dermatologists and acne vulgaris patients to initiate oral isotretinoin treatment safely during the pandemic period. |
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| MeSH term(s) | Acne Vulgaris/drug therapy ; Acne Vulgaris/epidemiology ; Administration, Oral ; COVID-19 ; Cohort Studies ; Dermatologic Agents/adverse effects ; Humans ; Isotretinoin/adverse effects ; Pandemics ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers | |||||
| Chemical Substances | Dermatologic Agents ; Isotretinoin (EH28UP18IF) | |||||
| Language | English | |||||
| Publishing date | 2021-04-29 | |||||
| Publishing country | England | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 2280551-5 | |||||
| ISSN | 1473-2165 ; 1473-2130 | |||||
| ISSN (online) | 1473-2165 | |||||
| ISSN | 1473-2130 | |||||
| DOI | 10.1111/jocd.14168 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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