Article ; Online: Bringing together components of the fly renal system.
Current opinion in genetics & development
2009 Volume 19, Issue 5, Page(s) 526–532
Abstract: ... The Drosophila excretory system is composed of filtration nephrocytes and Malpighian (renal) tubules. Here ... highlight the continuing usefulness of the fly to provide fundamental insights into the complexities ... we review recent molecular genetic data on the development and differentiation of nephrocytes and renal ...
| Abstract | The function of all animal excretory systems is to rid the body of toxins and to maintain homeostatic balance. Although excretory organs in diverse animal species appear superficially different they are often built on two common principals: filtration and tubular secretion/reabsorbtion. The Drosophila excretory system is composed of filtration nephrocytes and Malpighian (renal) tubules. Here we review recent molecular genetic data on the development and differentiation of nephrocytes and renal tubules. We focus in particular on the molecular mechanisms that underpin key cell and tissue behaviours during morphogenesis, drawing parallels with other species where they exist. Finally we assess the implications of patterned tissue differentiation for the subsequent regulation of renal function. These studies highlight the continuing usefulness of the fly to provide fundamental insights into the complexities of organ formation. |
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| MeSH term(s) | Animals ; Drosophila/embryology ; Embryo, Nonmammalian ; Kidney/embryology ; Kidney/physiology ; Models, Biological ; Urinary Tract/embryology ; Urinary Tract Physiological Phenomena ; Urination/physiology | |||||
| Language | English | |||||
| Publishing date | 2009-09-25 | |||||
| Publishing country | England | |||||
| Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review | |||||
| ZDB-ID | 1077312-5 | |||||
| ISSN | 1879-0380 ; 0959-437X | |||||
| ISSN (online) | 1879-0380 | |||||
| ISSN | 0959-437X | |||||
| DOI | 10.1016/j.gde.2009.08.006 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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