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Article ; Online: Roles of small RNAs in tumor formation.

Di Leva, Gianpiero / Croce, Carlo M

2010 Volume 16, Issue 6, Page(s) 257–267

Abstract: ... we discuss the etiology of the aberrant expression of miRNAs in human cancers and their role in tumor ... MicroRNAs (miRNAs) are small noncoding RNAs that act as post-transcriptional repressors ... processes driving the initiation and progression of various tumor types has recently been described. Here ...

Abstract	MicroRNAs (miRNAs) are small noncoding RNAs that act as post-transcriptional repressors of gene expression in organisms ranging from plants to humans. A widespread role for miRNAs in diverse molecular processes driving the initiation and progression of various tumor types has recently been described. Here, we discuss the etiology of the aberrant expression of miRNAs in human cancers and their role in tumor metastasis, which might define miRNAs as oncogenes or tumor suppressors. Moreover, we highlight the genomic/epigenetic alterations and transcriptional/post-transcriptional mechanisms associated with the misexpression of miRNAs in cancer. A better understanding of miRNA biology might ultimately yield further insight into the molecular mechanisms of tumorigenesis and new therapeutic strategies against cancer.
MeSH term(s)	Animals ; Epigenesis, Genetic/genetics ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Models, Biological ; Neoplasms/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2010-05-20
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2036490-8
ISSN	1471-499X ; 1471-4914
ISSN (online)	1471-499X
ISSN	1471-4914
DOI	10.1016/j.molmed.2010.04.001
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Article ; Online: Emerging roles of tRNA in cancer.

Ren, Daixi / Mo, Yongzhen / Yang, Mei / Wang, Dan / Wang, Yumin / Yan, Qijia / Guo, Can / Xiong, Wei / Wang, Fuyan / Zeng, Zhaoyang

Cancer letters

2023 Volume 563, Page(s) 216170

Abstract: Transfer RNAs (tRNAs) play pivotal roles in the transmission of genetic information, and ... roles in tumorigenesis, its formation process is far from clear. Understanding improper tRNA ... modifications and abnormal formation of tRFs in cancer is conducive to uncovering the role of metabolic process ...

Abstract	Transfer RNAs (tRNAs) play pivotal roles in the transmission of genetic information, and abnormality of tRNAs directly leads to translation disorders and causes diseases, including cancer. The complex modifications enable tRNA to execute its delicate biological function. Alteration of appropriate modifications may affect the stability of tRNA, impair its ability to carry amino acids, and disrupt the pairing between anticodons and codons. Studies confirmed that dysregulation of tRNA modifications plays an important role in carcinogenesis. Furthermore, when the stability of tRNA is impaired, tRNAs are cleaved into small tRNA fragments (tRFs) by specific RNases. Though tRFs have been found to play vital regulatory roles in tumorigenesis, its formation process is far from clear. Understanding improper tRNA modifications and abnormal formation of tRFs in cancer is conducive to uncovering the role of metabolic process of tRNA under pathological conditions, which may open up new avenues for cancer prevention and treatment.
MeSH term(s)	Humans ; RNA, Transfer/genetics ; RNA, Transfer/metabolism ; Anticodon ; Amino Acids ; Neoplasms/genetics
Chemical Substances	RNA, Transfer (9014-25-9) ; Anticodon ; Amino Acids
Language	English
Publishing date	2023-04-11
Publishing country	Ireland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	195674-7
ISSN	1872-7980 ; 0304-3835
ISSN (online)	1872-7980
ISSN	0304-3835
DOI	10.1016/j.canlet.2023.216170
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Article: Pan-cancer analysis reveals multifaceted roles of retrotransposon-fusion RNAs.

bioRxiv : the preprint server for biology

2023

Abstract: ... upon fusion formation. Overall cancer-specific L1 fusions were enriched in tumor suppressors while Alu fusions ... transposons was the most prevalent genic fusions, while somatic L1 insertions constituted a small fraction ... and hotspot loci within transposons vulnerable to fusion formation. Exonization of intronic ...

Abstract	Transposon-derived transcripts are abundant in RNA sequences, yet their landscape and function, especially for fusion transcripts derived from unannotated or somatically acquired transposons, remains underexplored. Here, we developed a new bioinformatic tool to detect transposon-fusion transcripts in RNA-sequencing data and performed a pan-cancer analysis of 10,257 cancer samples across 34 cancer types as well as 3,088 normal tissue samples. We identified 52,277 cancer-specific fusions with ~30 events per cancer and hotspot loci within transposons vulnerable to fusion formation. Exonization of intronic transposons was the most prevalent genic fusions, while somatic L1 insertions constituted a small fraction of cancer-specific fusions. Source L1s and HERVs, but not Alus showed decreased DNA methylation in cancer upon fusion formation. Overall cancer-specific L1 fusions were enriched in tumor suppressors while Alu fusions were enriched in oncogenes, including recurrent Alu fusions in
Language	English
Publishing date	2023-10-19
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.16.562422
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Article ; Online: YB1 associates with oncogenetic roles and poor prognosis in nasopharyngeal carcinoma.

Zhan, Yuting / Chen, Xianyong / Zheng, Hongmei / Luo, Jiadi / Yang, Yang / Ning, Yue / Wang, Haihua / Zhang, Yuting / Zhou, Ming / Wang, Weiyuan / Fan, Songqing

Scientific reports

2022 Volume 12, Issue 1, Page(s) 3699

Abstract: ... interfering RNAs can reduce the ability of proliferation, migration, invasion and SGs formation of NPC cells ... Nasopharyngeal carcinoma (NPC) is the malignant tumor arising from the nasopharynx epithelium ... associated with many kinds of malignant tumors. There is no systematic study about the regulation of YB1 and ...

Abstract	Nasopharyngeal carcinoma (NPC) is the malignant tumor arising from the nasopharynx epithelium with ethnic and geographical distribution preference. Y-box binding protein-1 (YB1) is the highly expressed DNA/RNA-binding protein with cold shock domain, and enhanced YB1 expression was proved to be associated with many kinds of malignant tumors. There is no systematic study about the regulation of YB1 and cell proliferation, migration, invasion and stress granules (SGs) in NPC, and the relationship between YB1 expression and clinical characteristics and prognosis of NPC patients. We analyzed the mRNA expression of YBX1 in head and neck squamous carcinoma (HNSC) and NPC in databases, investigated the functions of YB1 in cell proliferation, migration and invasion and SGs formation of NPC cells, and detected expression of YB1 protein in a large scale of NPC samples and analyzed their association with clinicopathological features and prognostic significance of NPC patients. YBX1 mRNA was significantly high expression in HNSC and NPC by bioinformatic analysis, and higher expression of YBX1 mRNA indicated poorer prognosis of HNSC patients. Clinically, the expression of YB1 in NPC tissues was significantly higher than these in the control nasopharyngeal epithelial tissues. We further found that the expression of YB1 had an evidently positive relation with advanced clinical stages of patients with NPC. The overall survival rates (OS) were significantly lower for NPC patients with positive expression of YB1. Multivariate analysis confirmed that positive expression of YB1 was the independent poorer prognostic factor for patients with NPC. Moreover, compared with the immortalized nasopharyngeal epithelial cell line (NP69), the basal level of YB1 in NPC cell lines was significantly higher. Knocking down YB1 may inhibit Akt/mTOR pathway in NPC cells. Knocking down YB1 by small interfering RNAs can reduce the ability of proliferation, migration, invasion and SGs formation of NPC cells. The expression of YB1 in NPC cell lines or patients with NPC was significantly higher. The high expression of YB1 protein may act as one valuable independent biomarker to predict poor prognosis for patients with NPC. Knocking down YB1 may release the malignant phenotype of NPC cells.
MeSH term(s)	Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Movement/genetics ; Cell Proliferation/genetics ; Cell Transformation, Neoplastic/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; Nasopharyngeal Carcinoma/genetics ; Nasopharyngeal Neoplasms/pathology ; Prognosis ; RNA, Messenger/genetics
Chemical Substances	RNA, Messenger
Language	English
Publishing date	2022-03-08
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-07636-z
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Article ; Online: microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance

Fattahi, Mehdi / Shahrabi, Saeid / Saadatpour, Fatemeh / Rezaee, Delsuz / Beyglu, Zahra / Delavari, Sana / Amrolahi, Anita / Ahmadi, Shirin / Bagheri-Mohammadi, Saeid / Noori, Effat / Majidpoor, Jamal / Nouri, Shadi / Aghaei-Zarch, Seyed Mohsen / Falahi, Shahab / Najafi, Sajad / Le, Binh Nguyen

International Journal of Biological Macromolecules. 2023 Oct., v. 250 p.125863-

2023

Abstract: ... where they either can act with oncogenic function (oncomiRs) or tumor-suppressors role (referred as tumor-suppressor ... MicroRNAs (miRNAs) are small single-stranded RNAs belonging to a class of non-coding RNAs ... oncorepressor miRNAs). miR-382 is a well-studied miRNA, which is revealed to play regulatory roles ...

Abstract	MicroRNAs (miRNAs) are small single-stranded RNAs belonging to a class of non-coding RNAs with an average length of 18–22 nucleotides. Although not able to encode any protein, miRNAs are vastly studied and found to play role in various human physiologic as well as pathological conditions. A huge number of miRNAs have been identified in human cells whose expression is straightly regulated with crucial biological functions, while this number is constantly increasing. miRNAs are particularly studied in cancers, where they either can act with oncogenic function (oncomiRs) or tumor-suppressors role (referred as tumor-suppressor/oncorepressor miRNAs). miR-382 is a well-studied miRNA, which is revealed to play regulatory roles in physiological processes like osteogenic differentiation, hematopoietic stem cell differentiation and normal hematopoiesis, and liver progenitor cell differentiation. Notably, miR-382 deregulation is reported in pathologic conditions, such as renal fibrosis, muscular dystrophies, Rett syndrome, epidural fibrosis, atrial fibrillation, amelogenesis imperfecta, oxidative stress, human immunodeficiency virus (HIV) replication, and various types of cancers. The majority of oncogenesis studies have claimed miR-382 downregulation in cancers and suppressor impact on malignant phenotype of cancer cells in vitro and in vivo, while a few studies suggest opposite findings. Given the putative role of this miRNA in regulation of oncogenesis, assessment of miR-382 expression is suggested in a several clinical investigations as a prognostic/diagnostic biomarker for cancer patients. In this review, we have an overview to recent studies evaluated the role of miR-382 in oncogenesis as well as its clinical potential.
Keywords	Human immunodeficiency virus ; atrial fibrillation ; biomarkers ; bone formation ; carcinogenesis ; cell differentiation ; fibrosis ; hematopoiesis ; hematopoietic stem cells ; humans ; liver ; microRNA ; neoplasms ; nucleotides ; oxidative stress ; phenotype ; miRNA ; miR-382 ; Cancer ; Biomarker
Language	English
Dates of publication	2023-10
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.125863
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer.

Liu, Zelin / Ke, Shuai / Wang, Qinghua / Gu, Xuhang / Zhai, Guanzhong / Shao, Haoren / He, Mu / Guo, Jia

Experimental cell research

2023 Volume 429, Issue 2, Page(s) 113686

Abstract: ... cancers of the urinary tract. Latest studies have confirmed that long non-coding RNAs (lncRNAs) play a crucial role ... in a variety of cancers. Some of these lncRNAs code for small nucleolar RNAs (snoRNAs), called small nucleolar ... conducted to investigate the main role of lncRNA SNHG25 in PCa. Xenograft tumour growth model in nude mice ...

Abstract	Background: Prostate cancer (PCa) is one of the most deadly and metastatic cancers of the urinary tract. Latest studies have confirmed that long non-coding RNAs (lncRNAs) play a crucial role in a variety of cancers. Some of these lncRNAs code for small nucleolar RNAs (snoRNAs), called small nucleolar RNA host genes (SNHGs), which exert some value in predicting the prognosis of certain cancer patients, but little is known regarding the function of SNHGs within the PCa. Aim of the study: To explore the expression distribution and differential analysis of SNHGs in different tumors using RNA-seq and survival data from TCGA and GTEx, and to assess the potential impacts of the lncRNA SNHG25 on human PCa. To validate the expression of SNHG25 using experimental data and to investigate in detail its particular molecular biological function on PCa both in vivo and in vitro. Methods: LncRNA SNHG25 expression was analyzed by bioinformatic prediction and qPCR. CCK-8, EdU, transwell, wound healing, and western blotting assays were conducted to investigate the main role of lncRNA SNHG25 in PCa. Xenograft tumour growth model in nude mice was surveyed by in vivo imaging and Ki-67 staining. AKT pathway activator (SC79) was used to verify the interaction among SNHG25 and PI3K/AKT signaling pathway. Results: Bioinformatics analysis and experimental research illuminated that the expression of lncRNA SNHG25 was observably up-regulated in PCa tissues and cells. Moreover, SNHG25 knockdown restrained PCa cell proliferation, invasion and migration, while promoting apoptosis. Xenografts model confirmed that the si-SNHG25 group had a significant inhibitory effect on PCa tumour growth in vivo. Additionally, a series of gain-of-function analyses suggested that SNHG25 could activate the PI3K/AKT pathway to accelerate PCa progression. Conclusions: These in vitro and in vivo findings demonstrate that SNHG25 is highly expressed in PCa and facilitates PCa development through regulation of PI3K/AKT signaling pathway. SNHG25 acts as an oncogene to predict tumour malignancy and survival in PCa patients and may therefore become a promising potential molecular target for early detection and therapy of lethal PCa.
MeSH term(s)	Male ; Animals ; Mice ; Humans ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Small Nucleolar/genetics ; Proto-Oncogene Proteins c-akt/genetics ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Mice, Nude ; Prostatic Neoplasms/genetics ; Prostatic Neoplasms/pathology ; Cell Proliferation/genetics ; Cell Line, Tumor ; Gene Expression Regulation, Neoplastic/genetics ; Cell Movement/genetics
Chemical Substances	RNA, Long Noncoding ; RNA, Small Nucleolar ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-)
Language	English
Publishing date	2023-06-10
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1493-x
ISSN	1090-2422 ; 0014-4827
ISSN (online)	1090-2422
ISSN	0014-4827
DOI	10.1016/j.yexcr.2023.113686
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Article ; Online: YB1 associates with oncogenetic roles and poor prognosis in nasopharyngeal carcinoma

Yuting Zhan / Xianyong Chen / Hongmei Zheng / Jiadi Luo / Yang Yang / Yue Ning / Haihua Wang / Yuting Zhang / Ming Zhou / Weiyuan Wang / Songqing Fan

Scientific Reports, Vol 12, Iss 1, Pp 1-

2022 Volume 12

Abstract: ... interfering RNAs can reduce the ability of proliferation, migration, invasion and SGs formation of NPC cells ... Abstract Nasopharyngeal carcinoma (NPC) is the malignant tumor arising from the nasopharynx ... associated with many kinds of malignant tumors. There is no systematic study about the regulation of YB1 and ...

Abstract	Abstract Nasopharyngeal carcinoma (NPC) is the malignant tumor arising from the nasopharynx epithelium with ethnic and geographical distribution preference. Y-box binding protein-1 (YB1) is the highly expressed DNA/RNA-binding protein with cold shock domain, and enhanced YB1 expression was proved to be associated with many kinds of malignant tumors. There is no systematic study about the regulation of YB1 and cell proliferation, migration, invasion and stress granules (SGs) in NPC, and the relationship between YB1 expression and clinical characteristics and prognosis of NPC patients. We analyzed the mRNA expression of YBX1 in head and neck squamous carcinoma (HNSC) and NPC in databases, investigated the functions of YB1 in cell proliferation, migration and invasion and SGs formation of NPC cells, and detected expression of YB1 protein in a large scale of NPC samples and analyzed their association with clinicopathological features and prognostic significance of NPC patients. YBX1 mRNA was significantly high expression in HNSC and NPC by bioinformatic analysis, and higher expression of YBX1 mRNA indicated poorer prognosis of HNSC patients. Clinically, the expression of YB1 in NPC tissues was significantly higher than these in the control nasopharyngeal epithelial tissues. We further found that the expression of YB1 had an evidently positive relation with advanced clinical stages of patients with NPC. The overall survival rates (OS) were significantly lower for NPC patients with positive expression of YB1. Multivariate analysis confirmed that positive expression of YB1 was the independent poorer prognostic factor for patients with NPC. Moreover, compared with the immortalized nasopharyngeal epithelial cell line (NP69), the basal level of YB1 in NPC cell lines was significantly higher. Knocking down YB1 may inhibit Akt/mTOR pathway in NPC cells. Knocking down YB1 by small interfering RNAs can reduce the ability of proliferation, migration, invasion and SGs formation of NPC cells. The expression of YB1 in NPC cell ...
Keywords	Medicine ; R ; Science ; Q
Subject code	616
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article: Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.

Liu, Qiang / Zhang, Xin / Hu, Xiaoqing / Yuan, Lan / Cheng, Jin / Jiang, Yanfang / Ao, Yingfang

Molecular therapy. Nucleic acids

2017 Volume 7, Page(s) 223–230

Abstract: ... could suppress tumor necrosis factor alpha (TNF-α) expression and increase extracellular matrix (ECM) formation ... Circular RNAs (circRNAs) are involved in the development of various diseases; however, knowledge ... in chondrocytes. circRNAs-MSR were silenced using small interfering RNA, and knockdown of circRNAs-MSR ...

Abstract	Circular RNAs (circRNAs) are involved in the development of various diseases; however, knowledge on circRNAs in osteoarthritis (OA) is limited. This study aims to identify circRNA expression in different regions affected by OA and to explore the function of mechanical stress-related circRNAs (circRNAs-MSR) in cartilage. Bioinformatics was employed to predict the interaction of circRNAs and mRNAs in the cartilage. Loss-of-function experiments for circRNAs-MSR were performed in vitro. A total of 104 circRNAs were differentially expressed in damaged versus intact cartilage. Of these circRNAs, 44 and 60 were upregulated and downregulated, respectively, in the damaged tissue. circRNA-MSR expression increased under mechanical stress in chondrocytes. circRNAs-MSR were silenced using small interfering RNA, and knockdown of circRNAs-MSR could suppress tumor necrosis factor alpha (TNF-α) expression and increase extracellular matrix (ECM) formation. Our results demonstrated that circRNAs-MSR regulated TNF-α expression and participated in the chondrocyte ECM degradation process. We propose that the inhibition of circRNAs-MSR could inhibit the degradation of chondrocyte ECM and knockdown of circRNAs-MSR could be a potential therapeutic target for OA.
Language	English
Publishing date	2017-04-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2662631-7
ISSN	2162-2531
ISSN	2162-2531
DOI	10.1016/j.omtn.2017.04.004
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Article: Alterations of miRNAs and Their Potential Roles in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells.

Gu, Shiyan / Sun, Donglei / Li, Xinyang / Zhang, Zunzhen

Genes

2017 Volume 8, Issue 10

Abstract: The alterations of micro RNAs (miRNAs) and their potential roles in arsenite-induced tumorigenesis ... non-small cell lung cancer, Wnt signaling pathway, cell cycle, and p53 signaling pathway. The miRNA-gene regulatory network ... migration and clone formation. Subsequently, 191 dysregulated miRNAs were identified to be associated ...

Abstract	The alterations of micro RNAs (miRNAs) and their potential roles in arsenite-induced tumorigenesis are still poorly understood. In this study, miRNA Array was used to detect the expression level of miRNAs in human bronchial epithelial (HBE) cells that were transformed by 2.5 μM arsenite for 13 weeks. These cells exhibited a neoplastic phenotype manifested by increased levels of cellular proliferation and migration and clone formation. Subsequently, 191 dysregulated miRNAs were identified to be associated with arsenite-induced transformation by miRNA Array. Among them, six miRNAs were validated by their expression levels with quantitative real-time polymerase chain reaction (qPCR), and 17 miRNAs were further explored via their target genes as well as regulatory network. Three databases, TargetMiner, miRDB, and TarBase, were used to predict the target genes of the 17 miRNAs, and a total of 954 common genes were sorted. Results of Gene Ontology (GO) analyses showed that the 954 genes were involved in diverse terms of GO categories, such as positive regulation of macroautophagy, epithelial cell maturation, and synaptic vesicle clustering. Moreover, results of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses demonstrated that most of these target genes were enriched in various cancer-related pathways, including non-small cell lung cancer, Wnt signaling pathway, cell cycle, and p53 signaling pathway. The miRNA-gene regulatory network, which was constructed by cytoscape software with miRNAs and their target genes, showed that miR-15b-5p, miR-106b-5p, and miR-320d were the core hubs. Collectively, our results provide new insights into miRNA-mediated mechanisms underlying arsenite-induced transformation, although more experimental verification is still needed to prove these predictions.
Language	English
Publishing date	2017-10-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes8100254
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Article ; Online: Emerging roles of non-coding RNAs in gastric cancer: Pathogenesis and clinical implications.

Xie, Shan-Shan / Jin, Juan / Xu, Xiao / Zhuo, Wei / Zhou, Tian-Hua

World journal of gastroenterology

2016 Volume 22, Issue 3, Page(s) 1213–1223

Abstract: ... lncRNAs play key roles in the formation and progression of many cancers. In this review, we focus ... on the regulation of miRNAs and lncRNAs in gastric cancer. miRNAs and lncRNAs appear to be involved in gastric tumor ... roles of ncRNAs in gastric cancer development and their possible clinical significance. ...

Abstract	Gastric cancer is a leading cause of cancer-related deaths. However, the mechanisms underlying gastric carcinogenesis remain largely unclear. The association of non-coding RNAs (ncRNAs) with cancer has been widely studied during the past decade. In general, ncRNAs have been classified as small ncRNAs, including microRNAs (miRNAs), and long non-coding RNAs (lncRNAs). Emerging evidence shows that miRNAs and lncRNAs play key roles in the formation and progression of many cancers. In this review, we focus on the regulation of miRNAs and lncRNAs in gastric cancer. miRNAs and lncRNAs appear to be involved in gastric tumor growth, invasion, and metastasis and in establishment of the gastric tumor microenvironment through various mechanisms. Furthermore, we also discuss the possibilities of establishing miRNAs and lncRNAs as potential biomarkers and therapeutic targets for gastric cancer. Taken together, we summarize the emerging roles of ncRNAs in gastric cancer development and their possible clinical significance.
MeSH term(s)	Animals ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Cell Movement ; Cell Proliferation ; Gene Expression Regulation, Neoplastic ; Genetic Predisposition to Disease ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Neoplasm Invasiveness ; Phenotype ; RNA, Long Noncoding/genetics ; RNA, Long Noncoding/metabolism ; RNA, Untranslated/genetics ; RNA, Untranslated/metabolism ; Risk Factors ; Stomach Neoplasms/genetics ; Stomach Neoplasms/metabolism ; Stomach Neoplasms/pathology ; Tumor Microenvironment
Chemical Substances	Biomarkers, Tumor ; MicroRNAs ; RNA, Long Noncoding ; RNA, Untranslated
Language	English
Publishing date	2016-01-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v22.i3.1213
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